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Donepezil

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Identification
Molecular formula
C24H29NO3
CAS number
120014-06-4
IUPAC name
1-[5-[2-(diethylamino)ethoxy]-2-methyl-1-(p-tolyl)indol-3-yl]ethanone
State
State

At room temperature, donepezil is typically in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.00
Boiling point (Celsius)
570.00
Boiling point (Kelvin)
843.00
General information
Molecular weight
379.49g/mol
Molar mass
379.4920g/mol
Density
1.2100g/cm3
Appearence

Donepezil is a white to off-white crystalline powder, commonly supplied in its hydrochloride form.

Comment on solubility

Solubility of 1-[5-[2-(diethylamino)ethoxy]-2-methyl-1-(p-tolyl)indol-3-yl]ethanone

The compound 1-[5-[2-(diethylamino)ethoxy]-2-methyl-1-(p-tolyl)indol-3-yl]ethanone exhibits interesting solubility characteristics, influenced by its complex structure and the presence of various functional groups. Understanding its solubility is crucial for various applications, including pharmaceutical formulations.

Key Points on Solubility:

  • Polar and Non-Polar Characteristics: The presence of the diethylamino and ethoxy groups suggests the compound may possess polar characteristics, while the p-tolyl group adds a non-polar component. This dual nature often leads to solubility in both polar and non-polar solvents.
  • Solvent Compatibility: The compound is likely soluble in organic solvents such as ethanol, methanol, and acetone, but may have limited solubility in aqueous solutions due to the hydrophobic aromatic rings.
  • Influence of Temperature: Solubility tends to increase with temperature; therefore, it is recommended to perform solubility tests at varying temperatures to identify optimal conditions.

In summary, the solubility of this compound can be described as variable depending on the solvent used and the temperature of the environment. It is always advisable to conduct specific solubility tests to determine the most effective medium for your particular application.

Interesting facts

Interesting Facts about 1-[5-[2-(diethylamino)ethoxy]-2-methyl-1-(p-tolyl)indol-3-yl]ethanone

This unique compound belongs to a class of molecules known as indoles, which are known for their diverse biological activities. Here are some interesting facts about this intriguing compound:

  • Biological Significance: Compounds containing indole structures are often found in many natural products and have been recognized for their roles in various biological activities, including antibacterial and anti-cancer properties.
  • Pharmacological Potential: The presence of substituents like diethylamino and toluy is indicative of potential enhanced pharmacological properties, making this compound a candidate for drug development.
  • Structure-Activity Relationship: Understanding how the different functional groups in this molecule interact with biological targets can provide insight into its mechanism of action. The indole backbone is known to interact with numerous receptors and enzymes in the body.
  • Versatility in Synthesis: The synthesis of such compounds can often involve several unique organic chemistry techniques, offering students and chemists a valuable opportunity to explore reaction mechanisms, such as nucleophilic substitutions and coupling reactions.
  • Interdisciplinary Appeal: This compound showcases how organic chemistry intersects with medicinal chemistry, providing an excellent case study for students to understand how chemical structure influences biological activity.

In summary, 1-[5-[2-(diethylamino)ethoxy]-2-methyl-1-(p-tolyl)indol-3-yl]ethanone presents a wealth of opportunities for research and application within the fields of chemistry and pharmacology. Its intricate structure and potential biological implications make it a fascinating subject for both budding chemists and seasoned researchers alike.