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Dantrolene

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Identification
Molecular formula
C14H10Cl2N4O5
CAS number
7261-97-4
IUPAC name
1-[[5-(3,4-dichlorophenyl)-2-furyl]methyleneamino]imidazolidine-2,4-dione
State
State

At room temperature, Dantrolene is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
289.00
Melting point (Kelvin)
562.15
Boiling point (Celsius)
372.00
Boiling point (Kelvin)
645.15
General information
Molecular weight
314.22g/mol
Molar mass
314.2150g/mol
Density
1.5004g/cm3
Appearence

Dantrolene is a yellow crystalline powder. It is sparingly soluble in water and soluble in methanol and in ethanol.

Comment on solubility

Solubility of 1-[[5-(3,4-dichlorophenyl)-2-furyl]methyleneamino]imidazolidine-2,4-dione

The solubility of 1-[[5-(3,4-dichlorophenyl)-2-furyl]methyleneamino]imidazolidine-2,4-dione can be quite complex due to its multifaceted structure. Here are some key points that might help understand its solubility characteristics:

  • Polarity: The presence of both electron-donating and electron-withdrawing groups may influence the compound's polarity, affecting solubility in various solvents.
  • Solvent Compatibility: This compound may exhibit different solubility in:
    • Aqueous solutions: Typically, amides can be moderately soluble in water due to the ability to form hydrogen bonds.
    • Organic solvents: Non-polar or moderately polar solvents (like DMSO or acetone) may solubilize this compound better than water.
  • Temperature Effects: As with many compounds, solubility may increase with temperature, making it essential to consider the conditions under which the solubility is assessed.
  • Crystallinity: The physical form (amorphous vs. crystalline) can significantly impact solubility; highly crystalline forms may dissolve less readily than their amorphous counterparts.

In summary, exploring the solubility of this compound demands a comprehensive understanding of its structural features and the nature of the solvents involved. As a general note, it is crucial to conduct experimental assessments for precise solubility data.

Interesting facts

Interesting Facts about 1-[[5-(3,4-dichlorophenyl)-2-furyl]methyleneamino]imidazolidine-2,4-dione

This intriguing compound is part of the imidazolidine family, known for its diverse biological activities and potential therapeutic applications. It is particularly noteworthy for the following reasons:

  • Biological Significance: Compounds with imidazolidine structures often exhibit significant pharmacological properties. This specific compound has shown promise in various studies related to anti-inflammatory and anti-cancer activities.
  • Structure-Activity Relationship: The presence of the 3,4-dichlorophenyl group enhances the compound’s efficacy. The intricate interactions of this substituent with biological targets could be a fruitful area for research.
  • Furan Ring Contribution: The incorporation of the furan moiety introduces interesting electronic properties and may facilitate various chemical reactions, highlighting the versatility of this compound.
  • Potential Applications: Beyond its pharmacological potential, research into this compound can lead to innovations in fields such as agricultural chemistry, where similar structures have been found effective against pests.

As a compound that embodies the fusion of diverse functional groups, this imidazolidine derivative serves as a perfect example of how molecular design can be tailored for specific biological activities. It's a captivating subject for chemists interested in drug design and development.

In the words of Albert Einstein, "Scientists investigate that which already is; engineers create that which has never been." This compound sits at the intersection of investigation and innovation, presenting a multitude of avenues for future exploration.

Synonyms
Hydantoin, 1-((5-(3,4-dichlorophenyl)furfurylidene)amino)- (8CI)
MLS006011935
SCHEMBL11506877
DTXSID70864535
AKOS034695473
SMR002529509
1-({[5-(3,4-dichlorophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione