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Loratadine

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Identification
Molecular formula
C22H23ClN2O2
CAS number
79794-75-5
IUPAC name
1-[5-chloro-2-[2-(diisopropylamino)ethoxy]phenyl]butan-1-one
State
State

At room temperature, Loratadine is typically found in solid state, appearing as a powder.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
381.40
Boiling point (Kelvin)
654.60
General information
Molecular weight
382.89g/mol
Molar mass
382.8720g/mol
Density
1.1364g/cm3
Appearence

Loratadine appears as a white to off-white crystalline powder. It is typically tasteless and odorless.

Comment on solubility

Solubility of 1-[5-chloro-2-[2-(diisopropylamino)ethoxy]phenyl]butan-1-one

The solubility of 1-[5-chloro-2-[2-(diisopropylamino)ethoxy]phenyl]butan-1-one can be influenced by several factors. This compound features a complex structure that includes various functional groups, which could affect its interaction with solvents.

Key Considerations for Solubility:

  • Polar vs. Nonpolar Solvents: Given the presence of the diisopropylamino group, this compound may be more soluble in polar organic solvents, such as methanol or ethanol, compared to nonpolar solvents like hexane.
  • Hydrogen Bonding: The potential for hydrogen bonding due to the ethoxy group can enhance solubility in polar solvents.
  • Temperature Effect: Increased temperature typically increases solubility for many compounds, making it a critical factor when studying solubility behaviors.
  • pH Conditions: The solubility may vary significantly depending on the pH of the solution, especially if the compound can ionize.

Overall, the specific solubility characteristics of 1-[5-chloro-2-[2-(diisopropylamino)ethoxy]phenyl]butan-1-one must be determined experimentally, taking into account these various factors.

Interesting facts

Interesting Facts about 1-[5-chloro-2-[2-(diisopropylamino)ethoxy]phenyl]butan-1-one

This compound is a fascinating example of a synthetic organic molecule that integrates multiple functional groups, highlighting its potential in medicinal chemistry and drug development.

Key Characteristics:

  • Chiral Centers: The presence of chiral centers in the compound may contribute to its biological activity, leading to different effects of its enantiomers in pharmacological applications.
  • Functional Groups: The compound features both a ketone and an ether linkage, making it versatile for various chemical reactions, such as nucleophilic attacks and substitutions.
  • Drug Development Potential: Compounds like this can serve as scaffolds for the development of new therapeutic agents, particularly in treating conditions related to the central nervous system.
  • Structure-Activity Relationship (SAR): Studying SAR can reveal how structural modifications can enhance the efficacy or decrease the side effects of analogues derived from this compound.

Furthermore, the incorporation of the diisopropylamino group may considerably impact the compound’s solubility and membrane permeability, which are crucial factors in drug design. As emphasized by many pharmacologists, "the right chemical structure can make the difference between a drug that is effective and one that fails in clinical trials."

In sum, this compound serves as not just a chemical entity, but as a prospect for innovative research in fields like synthetic chemistry, pharmacology, and medicinal chemistry, illustrating the intricate relationships between structure and function in the realm of chemical compounds.

Synonyms
BRN 2588217
20809-23-8
BUTYROPHENONE, 5'-CHLORO-2'-(2-(DIISOPROPYLAMINO)ETHOXY)-
DTXSID40174916
2-Butyryl-4-chloro-beta-(N,N-diisopropyl)phenoxyethylamine
Butyrophenone, 3'-chloro-6'-(2-(diisopropylamino)ethoxy)-
DTXCID0097407
RefChem:331477