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Dihydrothymidine

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Identification
Molecular formula
C10H14N2O5
CAS number
6960-76-7
IUPAC name
1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
State
State

At room temperature, Dihydrothymidine is in a solid state. It is typically stored in powder or crystalline form and kept in a dry environment to prevent degradation by moisture.

Melting point (Celsius)
164.00
Melting point (Kelvin)
437.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
242.24g/mol
Molar mass
242.2460g/mol
Density
2.3200g/cm3
Appearence

Dihydrothymidine typically appears as a white crystalline solid. It is a derivative of thymidine and has a specific crystalline structure that can be analyzed by X-ray diffraction.

Comment on solubility

Solubility of 1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione (C10H14N2O5)

The solubility of a compound can vary significantly based on its structural characteristics and environmental conditions. In the case of 1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione, several points are noteworthy:

  • Polarity: The presence of hydroxymethyl and carbonyl groups often enhances polarity, which may improve solubility in polar solvents such as water.
  • Hydrogen Bonding: The potential for hydrogen bonding due to the hydroxyl group could facilitate interactions with water molecules, suggesting higher solubility in aqueous environments.
  • Organic Solvents: Given its hydrophilic characteristics, it might have moderate solubility in organic solvents, especially those with polar characteristics.

However, it is essential to note that specific solubility data may vary based on temperature and other factors. In general, compounds with similar structures tend to show a trend where increased hydroxyl groups correlate with increased solubility. Therefore, one could anticipate that this compound may display favorable solubility profiles in polar solvents, although empirical testing would provide the most accurate information.

Interesting facts

Exploring 1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione is a fascinating compound that sits at the intersection of organic chemistry and pharmaceutical research. Known for its unique structure and properties, this compound warrants a closer look due to several noteworthy aspects:

  • Molecular Versatility: This compound features a pyrimidine ring, which is pivotal in many biological systems and is a structural component of various nucleotides.
  • Biological Relevance: The presence of hydroxymethyl and dihydrofuran functional groups highlights its potential significance in biological applications, particularly in drug development and synthesis.
  • Chemical Behavior: As a diketone, it exhibits reactivity that can be harnessed for different chemical reactions, making it a valuable intermediate in organic synthesis.
  • Research Potential: The intriguing design of this compound indicates potential uses in therapies targeting various diseases, making it a subject of interest in medicinal chemistry.

As scientists continue to explore its intricate profiles, this compound exemplifies the complexity and beauty of organic molecules within the realm of chemistry. The interactions between its various functional groups not only enhance its reactivity but also open doors to new possibilities in synthetic pathways and drug design.

The exploration of such compounds reiterates an evergreen truth in chemistry: "Innovation often arises from the recombination of existing elements in novel ways." Thus, research on 1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione could lead to groundbreaking discoveries in the future.

Synonyms
Stavudine (d4T)
26638-87-9
1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1h,3h)-dione
SMR000018784
MFCD00132921
?-Stavudine
NSC 163661
1-(5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
1-(2,3-Dideoxy-a-D-glycero-pent-2-enofuranosyl)thymine
Oprea1_305252
MLS000061738
MLS000103441
CHEMBL418334
SCHEMBL9999805
DTXSID10859788
HMS1653P11
HMS2327P19
HMS3393O20
HMS3654H04
JDA41490
s1398
STL529152
1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione
AKOS003631533
AKOS037495508
NCGC00015325-04
LS-13786
NCI60_001242
SY057970
BCP0726000259
SW220279-1
EN300-296071
AB00391063-04
AB00391063-07
AB00391063_08
BRD-A06317634-001-10-2
1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine;2',3'-Anhydrothymidine
4-hydroxy-1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidin-2(1H)-one