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Nitrofurantoin

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Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
1-[5-methyl-3-(5-nitro-2-furyl)isoxazol-4-yl]ethanone
State
State

At room temperature, nitrofurantoin exists as a solid, specifically as crystalline powder that is stable under normal conditions.

Melting point (Celsius)
268.00
Melting point (Kelvin)
541.15
Boiling point (Celsius)
553.80
Boiling point (Kelvin)
826.95
General information
Molecular weight
238.17g/mol
Molar mass
238.1680g/mol
Density
1.6824g/cm3
Appearence

Nitrofurantoin typically appears as a yellow crystalline powder. It is known for its slightly bitter taste and practically odorless nature.

Comment on solubility

Solubility of 1-[5-methyl-3-(5-nitro-2-furyl)isoxazol-4-yl]ethanone

The solubility of 1-[5-methyl-3-(5-nitro-2-furyl)isoxazol-4-yl]ethanone is a crucial aspect that can influence its application in various fields, particularly in pharmaceuticals and chemical synthesis. This compound, with its complex structure, displays distinct solubility characteristics that are important to consider:

  • Polar vs. Non-Polar Solvents: Its solubility is expected to vary significantly between polar and non-polar solvents due to the presence of functional groups.
  • Temperature Effects: Like many organic compounds, the solubility may increase with temperature, suggesting thorough mixing during heating to achieve maximum solvent interaction.
  • pH Sensitivity: The behavior of this compound in different pH environments can also greatly affect its solubility, possibly leading to ionization.

In terms of solubility in water, it is likely to be moderate to low, which is common for many organic compounds with substantial aromatic systems. For instance, the presence of the nitro group could enhance polarity slightly, but not enough to guarantee high solubility in water.

In summary, understanding the solubility of 1-[5-methyl-3-(5-nitro-2-furyl)isoxazol-4-yl]ethanone is essential for its effective utilization in preparation and reactive scenarios. As always, experimentation under varying conditions is recommended to obtain precise solubility data!

Interesting facts

Interesting Facts about 1-[5-methyl-3-(5-nitro-2-furyl)isoxazol-4-yl]ethanone

This compound, known for its complex structure and unique functional groups, is a fascinating subject of study in organic chemistry. Here are some intriguing aspects:

  • Isomeric Diversity: The compound belongs to a class of isoxazoles, which are characterized by their five-membered ring structure containing both nitrogen and oxygen. The dual presence of both furan and isoxazole rings in its structure enhances its chemical reactivity, leading to a rich scope of isomeric derivatives.
  • Biological Activity: Compounds like this one, with isoxazole and nitro groups, often exhibit promising biological properties. Research indicates that such derivatives may possess antibacterial and antifungal activities, making them potential candidates for pharmaceutical applications.
  • Environmental Impact: Nitro-containing compounds are significant in environmental chemistry, as they can participate in various chemical reactions in natural waters and soil. The study of their degradation pathways is crucial for assessing ecological risks.
  • Applications in Synthesis: The presence of the furyl group adds to the versatility of the compound in organic synthesis and the development of agrochemicals. It can serve as a precursor for synthesizing other valuable compounds, showcasing its role in heterocyclic chemistry.
  • Analytical Techniques: The distinct functional groups associated with this compound allow chemists to explore various analytical techniques for its characterization. Techniques such as NMR (Nuclear Magnetic Resonance) and mass spectrometry are essential for understanding its structure and reactivity.

As one dives deeper into the study of this compound, it becomes clear that its unique structure not only lends to its chemical properties but also opens avenues for significant applications in medicinal chemistry and environmental studies. As emphasized by many chemists, "Understanding the structure-function relationship is key to innovation in chemistry."

Synonyms
BRN 0618013
15154-19-5
KETONE, METHYL 5-METHYL-3-(5-NITRO-2-FURYL)-4-ISOXAZOLYL
Methyl 5-methyl-3-(5-nitro-2-furyl)-4-isoxazolyl ketone
DTXSID90164802
DTXCID9087293
4-Acetyl-5-methyl-3-(5-nitro-2-furyl)isoxazole
1-[5-methyl-3-(5-nitro-2-furyl)isoxazol-4-yl]ethanone