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Nifuroxazide

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Identification
Molecular formula
C12H9N3O5
CAS number
965-52-6
IUPAC name
1-(5-nitro-2-furyl)-N-phenyl-methanimine
State
State

At room temperature, nifuroxazide is a solid. It does not melt easily, indicating it is thermally stable under normal conditions.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
276.22g/mol
Molar mass
276.2180g/mol
Density
1.5120g/cm3
Appearence

At room temperature, nifuroxazide appears as an orange-yellow crystalline powder. It is typically fine and has a bright yellow hue, characteristic of nitrofuran derivatives.

Comment on solubility

Solubility of 1-(5-nitro-2-furyl)-N-phenyl-methanimine

The solubility of 1-(5-nitro-2-furyl)-N-phenyl-methanimine can be affected by various factors, including its molecular structure and interactions with solvents. Here are some key points to consider:

  • Polarity: The compound contains both a nitro group and an imine, which may influence its polarity significantly.
  • Solvent interactions: Solubility behavior can vary depending on the choice of solvent. Generally, polar solvents may solubilize polar functional groups effectively.
  • Hydrogen bonding: The existence of functional groups conducive to hydrogen bonding could enhance solubility in solvents capable of such interactions.
  • Temperature dependence: The solubility might increase with temperature, which is a common phenomenon observed with many organic compounds.

Ultimately, while specific numerical solubility data for 1-(5-nitro-2-furyl)-N-phenyl-methanimine may not be readily available, understanding the underlying principles of solubility can offer insights into its behavior in different solvent systems. As stated, “Like dissolves like” is a fundamental rule in chemistry that underpins solubility trends across various compounds.

Interesting facts

Interesting Facts about 1-(5-Nitro-2-furyl)-N-phenyl-methanimine

1-(5-Nitro-2-furyl)-N-phenyl-methanimine, often referred to as a nitro-containing furan derivative, is a compound of significant interest in both organic chemistry and medicinal research. Here are some intriguing aspects of this compound:

  • Potential Pharmaceutical Applications: Due to the presence of the nitro group and the furan ring, this compound exhibits a variety of biological activities that make it a candidate for pharmaceutical research. Compounds with similar structures have been studied for their potential as anti-cancer agents.
  • Importance of Furan Rings: Furans are a class of organic compounds known for their stability and reactivity. The furan ring in this compound contributes to its unique chemical properties and opens avenues for further chemical transformations.
  • Synthetic Versatility: The synthesis of 1-(5-nitro-2-furyl)-N-phenyl-methanimine can be achieved through various methods, showcasing the versatility of reaction conditions and substrates in organic synthesis.
  • Electrophilic Character: The presence of the nitro group on the furan ring enhances the electrophilic character of certain areas in the molecule, which may facilitate interactions with nucleophiles in biological systems, potentially influencing pharmacodynamics.
  • Research Opportunities: The compound’s unique structure provides an exciting platform for research into new derivatives that may enhance desired biological activities or minimize side effects. Scientists often explore structure-activity relationships to optimize such compounds.

As a scientist or a chemistry student, the study of 1-(5-nitro-2-furyl)-N-phenyl-methanimine presents a fascinating intersection of organic synthesis, medicinal chemistry, and the exploration of new therapeutic agents. It exemplifies how subtle modifications in molecular structure can lead to substantial changes in reactivity and biological activity.

Synonyms
N-(5-Nitrofurfurylidene)aniline
156-44-5
BRN 0174736
ANILINE, N-(5-NITROFURFURYLIDENE)-
N-((5-Nitro-2-furanyl)methylene)benzenamine
Benzenamine, N-((5-nitro-2-furanyl)methylene)-
DTXSID701303561
5-17-09-00325 (Beilstein Handbook Reference)
N-((5-Nitrofuran-2-yl)methylene)aniline
DTXCID601733593
STK756698
AKOS001733642
EU-0051645
N-[(E)-(5-nitro-2-furyl)methylidene]aniline
N-[(E)-(5-nitrofuran-2-yl)methylidene]aniline
(E)-1-(5-NITROFURAN-2-YL)-N-PHENYLMETHANIMINE
Benzenamine, N-((5-nitro-2-furanyl)methylene)-(9CI)
660-250-7