Skip to main content

Nitrofurantoin

ADVERTISEMENT
Identification
Molecular formula
C8H6N4O5
CAS number
67-20-9
IUPAC name
1-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2,4-dione
State
State

At room temperature, nitrofurantoin is a solid.

Melting point (Celsius)
270.00
Melting point (Kelvin)
543.00
Boiling point (Celsius)
515.50
Boiling point (Kelvin)
788.65
General information
Molecular weight
238.16g/mol
Molar mass
238.1570g/mol
Density
1.6800g/cm3
Appearence

Nitrofurantoin typically appears as a yellow, crystalline powder.

Comment on solubility

Understanding Solubility of 1-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2,4-dione

The solubility characteristics of 1-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2,4-dione (C8H6N4O5) are crucial for its applications in chemical processes and biological systems. This compound, with its diverse functional groups, showcases interesting solubility behavior that can be influenced by several factors:

  • Polar vs Non-polar Solvents: Due to the presence of nitro and carbonyl groups, the compound tends to be more soluble in polar solvents.
  • Hydrogen Bonding: The potential for hydrogen bonding can enhance solubility in water and alcohols.
  • Temperature Effects: Like many organic compounds, increased temperature may increase solubility.

In experimental conditions, great care should be taken to select the appropriate solvent to achieve higher solubility. As a general observation:

  1. The compound may have limited solubility in non-polar solvents such as hexane.
  2. It exhibits better solubility in polar organic solvents like ethanol or methanol.
  3. Its solubility in water may vary, and thus pH adjustments could also be explored to improve it.

In summary, solubility is a multifaceted property influenced by molecular interactions, making it vital to understand for effective use in applications. Experimentation will be key to unlocking the full potential of C8H6N4O5 in various environments.

Interesting facts

Interesting Facts About 1-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2,4-dione

1-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2,4-dione, often referred to by its more straightforward shorthand, is a fascinating compound that combines the structural features of imidazolidine diones with nitrofuran chemistry.

Key Characteristics:

  • Multifunctionality: The compound contains both an imidazolidine ring and a nitro group, providing diverse chemical reactivity and potential applications in various fields.
  • Biological Significance: Compounds similar to this have been studied for their antibacterial and antifungal properties, potentially aiding in the development of new pharmaceuticals.
  • Versatile Syntheses: The methodology for synthesizing this compound spans multiple techniques, offering chemists a playground for exploring different reaction conditions and reagents.

This compound is particularly notable for its potential use in medicinal chemistry. As stated by several researchers, “the fusion of nitrogenous rings with aromatic systems often leads to remarkable biological activities.” One investigative pathway involves examining its effects as a **biosensor**, especially in detecting pathogens due to the specificity provided by the furyl moiety.

Several studies have also explored the compound’s behavior under various conditions, leading to unique findings regarding its stability and reactivity based on external stimuli, paving the way for advances in smart drug delivery systems.

In summary, 1-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2,4-dione stands at the crossroads of synthetic chemistry and biological exploration, showcasing how intricate organic structures can lead to promising new discoveries.

Synonyms
67-20-9
1-[(5-nitro-2-furanyl)methylideneamino]imidazolidine-2,4-dione
Spectrum_001003
Prestwick0_000168
Prestwick1_000168
Spectrum2_001046
Spectrum3_000517
Spectrum4_000075
Oprea1_199544
Oprea1_513843
KBioGR_000629
KBioSS_001483
DivK1c_000224
SPBio_000972
SPBio_001956
CHEMBL1605821
KBio1_000224
KBio2_001483
KBio2_004051
KBio2_006619
KBio3_001573
NINDS_000224
HMS2231I15
HMS3259E21
HMS3374M07
Nitrofurantoin - Bio-X trade mark
AKOS028110053
NC00521
1-(5'-nitrofurfurylideneamino)hydantoin
FN182931
DB-054997
NS00001691
Q27167045
Furadoxyl;N-(5-Nitro-2-furfurylidene)-1-aminohydantoin;Nitrofurantoine