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Nitrothiazolyl Imidazolidinone

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Identification
Molecular formula
C6H6N4O3S
CAS number
937-14-4
IUPAC name
1-(5-nitrothiazol-2-yl)imidazolidin-2-one
State
State

The compound is solid at room temperature and is stable under standard conditions. It is typically handled in its solid form in laboratory settings and is soluble in organic solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). It is insoluble in water.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
345.00
Boiling point (Kelvin)
618.15
General information
Molecular weight
214.21g/mol
Molar mass
214.2050g/mol
Density
1.4500g/cm3
Appearence

1-(5-nitrothiazol-2-yl)imidazolidin-2-one is typically a crystalline solid with a pale yellow color. No distinctive odor is associated with this compound. It has a slightly granular form and displays light sensitivity, so it is usually stored in amber containers to avoid decomposition under light exposure.

Comment on solubility

Solubility of 1-(5-nitrothiazol-2-yl)imidazolidin-2-one (C6H6N4O3S)

The solubility of 1-(5-nitrothiazol-2-yl)imidazolidin-2-one is influenced by its unique chemical structure, which includes functional groups that interact with solvents in specific ways. When examining its solubility, consider the following points:

  • Polarity: The presence of both nitro and thiazole moieties introduces polarity, which may enhance solubility in polar solvents like water.
  • Solvent Interaction: This compound may exhibit variable solubility in organic solvents. For example, it is likely to dissolve better in solvent mixtures that can stabilize its polar regions.
  • Temperature Dependence: Solubility may increase at elevated temperatures, a common characteristic of many solid compounds.
  • pH Influence: The solubility could be affected by the pH of the solution, with potential variations in ionization impacting solubility.

In conclusion, the solubility behavior of 1-(5-nitrothiazol-2-yl)imidazolidin-2-one can be described as moderate and conditional, shaped by its polar nature and the interactions with different solvents. As always, empirical testing remains crucial for determining precise solubility in various media.

Interesting facts

Interesting Facts About 1-(5-nitrothiazol-2-yl)imidazolidin-2-one

1-(5-nitrothiazol-2-yl)imidazolidin-2-one is a fascinating compound that has gained attention in the field of medicinal chemistry due to its unique structural characteristics and potential therapeutic applications. Here are some noteworthy aspects of this compound:

  • Pharmacological Significance: This compound belongs to a class of molecules that may exhibit significant biological activity, particularly as antimicrobial agents. Its nitrothiazole moiety is known for its ability to enhance the activity of pharmaceuticals by interacting with various biological targets.
  • Versatile Synthesis: The synthetic pathways for preparing this compound involve intriguing organic reactions. This includes the formation of imidazolidinones, which are derivatives known for their stability and functionality in various chemical contexts.
  • Research Interests: Researchers are particularly interested in studying how modifications to the thiazole and imidazolidinone groups can affect the compound's biological properties. This opens new avenues in drug design and development.
  • Environmental Chemistry: The incorporation of nitrogen and sulfur within its structure suggests potential applications in environmental chemistry, where such compounds can be explored for their roles in biogeochemical cycles.
  • Future Potential: As the search for new therapeutic agents continues, compounds like 1-(5-nitrothiazol-2-yl)imidazolidin-2-one might play a crucial role in addressing antibiotic resistance and developing novel treatments for infectious diseases.

In summary, 1-(5-nitrothiazol-2-yl)imidazolidin-2-one is not only a compound of interest for its chemical properties but also for its potential implications in various scientific and medical fields. As researchers delve deeper into its functionalities, it could lead to significant advancements in health and environmental science.

Synonyms
Niridazole
61-57-4
Nitrothiazol
Nitrothiazole
Nitrothiamidazol
Nitrothiamidazole
Ambilhar
Niridazolum
Ciba 32644-Ba
Niridazol
Ciba 32644
2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-
BA 32644
Nitridazole
BA 32644 Ciba
1-(5-Nitro-2-thiazolyl)-2-imidazolinone
1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
Niridazol [INN-Spanish]
Niridazolum [INN-Latin]
1-(5-Nitro-2-thiazolyl)-2-oxotetrahydroimidazole
CCRIS 434
1-(5-NITRO-2-THIAZOLYL)-2-IMIDAZOLIDINONE
Niridazole [USAN:INN:BAN]
NSC 136947
HSDB 7480
EINECS 200-512-6
NSC-136947
BRN 0665338
NTOI
CIBA 32644BA
N116U8Y5QQ
DTXSID6045244
AI3-51833
NIRIDAZOLE [MI]
NIRIDAZOLE [INN]
NIRIDAZOLE [HSDB]
NIRIDAZOLE [IARC]
NIRIDAZOLE [USAN]
NIRIDAZOLE [MART.]
NIRIDAZOLE [WHO-DD]
NIRIDAZOLE [WHO-IP]
BA-32644
MLS002920381
DTXCID4025244
CHEBI:82349
NIRIDAZOLUM [WHO-IP LATIN]
NSC136947
CAS-61-57-4
NCGC00016277-01
1-(5-Nitro-2-thiazolyl)imidazolidin-2-one
Niridazol (INN-Spanish)
NIRIDAZOLE (IARC)
Niridazolum (INN-Latin)
NIRIDAZOLE (MART.)
1-(5-Nitro-2-thiazolyl)-2-oxotetrahydroimidazol
SMR001233194
UNII-N116U8Y5QQ
Prestwick_543
1-(5-NITROTHIAZOL-2-YL)IMIDAZOLIDIN-2-ONE
Niridazole (USAN/INN)
Prestwick0_000469
Prestwick1_000469
Prestwick2_000469
Prestwick3_000469
2-Imidazolidinone,1-(5-nitro-2-thiazolyl)-
Oprea1_249644
BSPBio_000578
MLS002153826
SCHEMBL126396
niridazole-chlorethylcarboxamide
SPBio_002517
BPBio1_000636
CHEMBL152632
P02BX02
HMS1569M20
HMS2096M20
HMS2231C14
HMS3374G02
HMS3713M20
Tox21_110343
AKOS040749027
CCG-220469
DB13661
WLN: T5N CSJ DNW B- CT5MVNTJ
NCGC00016277-02
TS-08590
1-(5-Nitro-2-thiazolyl)-2-imidazolidone
DS-013407
HY-119614
AB00513844
CS-0070057
NS00034731
1-(5-Nitro-thiazol-2-yl)-imidazolidin-2-one
C19268
D05170
SR-01000838830
1-(-5-Nitro-2-thiazolyl)-2-oxotetrahydroimidazole
Q7039974
SR-01000838830-2
1-(5-Nitro-1,3-thiazol-2-yl)-2-imidazolidinone #
BRD-K53123955-001-03-0
BRD-K53123955-001-10-5
200-512-6