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Lenalidomide

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Identification
Molecular formula
C13H13N3O3
CAS number
191732-72-6
IUPAC name
1-(5-oxo-1,2,3,9b-tetrahydropyrrolo[2,1-a]isoindol-9-yl)-3-(2-pyridyl)urea
State
State

At room temperature, lenalidomide is in a solid state. It appears as a fine powder and is used in the pharmaceutical industry for therapeutic purposes.

Melting point (Celsius)
269.00
Melting point (Kelvin)
542.15
Boiling point (Celsius)
458.40
Boiling point (Kelvin)
731.55
General information
Molecular weight
259.26g/mol
Molar mass
259.2610g/mol
Density
1.4580g/cm3
Appearence

Lenalidomide is typically a white or off-white crystalline powder. As a pharmaceutical compound, it is usually processed in a fine crystalline form for formulation into oral dosage forms such as capsules.

Comment on solubility

Solubility of 1-(5-oxo-1,2,3,9b-tetrahydropyrrolo[2,1-a]isoindol-9-yl)-3-(2-pyridyl)urea

The solubility characteristics of the compound 1-(5-oxo-1,2,3,9b-tetrahydropyrrolo[2,1-a]isoindol-9-yl)-3-(2-pyridyl)urea (C13H13N3O3) can be understood by considering several key factors:

  • Polarity: The presence of polar functional groups such as urea and carbonyl contributes to increased solubility in polar solvents like water.
  • Solvent Interaction: This compound may be more soluble in organic solvents due to its aromatic components, making it suitable for applications involving organic chemical processes.
  • Hydrogen Bonding: The ability of the urea nitrogen to form hydrogen bonds can enhance solubility in polar solvents.
  • Hydrophobic Regions: The tetrahydropyrrolo isoindole structure introduces hydrophobic characteristics which may impede solubility in water but allow for solubility in nonpolar solvents.

In summary, the solubility behavior of this compound is complex and influenced by its dual nature as both a polar and nonpolar entity. Therefore, it is often observed that:

  • Higher solubility in polar solvents due to hydrogen bonding.
  • Varied solubility in nonpolar solvents driven by hydrophobic interactions.

Special attention should be applied when selecting solvents for this compound to achieve optimal solubility and, consequently, effective application.

Interesting facts

Interesting Facts about 1-(5-Oxo-1,2,3,9b-tetrahydropyrrolo[2,1-a]isoindol-9-yl)-3-(2-pyridyl)urea

This intriguing compound showcases a unique molecular architecture that combines multiple functional groups, showcasing a blend of organic chemistry and medicinal potential. Here are some interesting insights:

  • Structural Complexity: The compound features a rare fused structure of a pyrrole and isoindole, which contributes to its potential biological activity and interactions with various molecular targets.
  • Potential Biological Applications: Compounds containing both urea and pyridine moieties are often evaluated for their pharmacological properties. This compound may serve as a lead structure in drug discovery, particularly in the realms of anticancer and neuroprotective agents.
  • Mechanisms of Action: The unique arrangement of atoms can lead to diverse mechanisms of action, possibly interacting with enzymes or receptors in ways that could modulate biological pathways responsibly.
  • Interdisciplinary Research: The synthesis and study of this compound likely require collaboration across various fields, including synthetic organic chemistry, medicinal chemistry, and molecular biology.
  • Research Notation: Its intricate structure often piques the interest of chemists who enjoy synthesizing novel compounds and elucidating their mechanisms of action through experimental techniques.

As we explore the diverse realm of chemical compounds, 1-(5-oxo-1,2,3,9b-tetrahydropyrrolo[2,1-a]isoindol-9-yl)-3-(2-pyridyl)urea is an excellent example of how merging different chemical functionalities can lead to compounds with promising properties, showcasing the potential of chemistry in addressing complex biological challenges. The investigation of this molecule can lead to significant contributions in both theoretical and applied sciences.

Synonyms
SCHEMBL13038776
PD039929
1-(5-oxo-2,3,5,9b-tetrahydro-1h-pyrrolo [2,1-a]isoindol-9-yl)-3-pyridin-2-yl-urea