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6-Chloro-3-(2-aminopropyl)indole

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Identification
Molecular formula
C11H13ClN2
CAS number
19034-16-3
IUPAC name
1-(6-chloro-1H-indol-3-yl)propan-2-amine
State
State

At room temperature, 6-Chloro-3-(2-aminopropyl)indole is in a solid state. It is typically stored in its stable, crystalline form for laboratory use.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
361.80
Boiling point (Kelvin)
634.95
General information
Molecular weight
206.68g/mol
Molar mass
206.6830g/mol
Density
1.2980g/cm3
Appearence

6-Chloro-3-(2-aminopropyl)indole appears as a white to off-white crystalline solid. The compound is typically encountered in powdered form and is known for its role in specialized chemical research.

Comment on solubility

Solubility of 1-(6-chloro-1H-indol-3-yl)propan-2-amine

The solubility of 1-(6-chloro-1H-indol-3-yl)propan-2-amine can vary significantly depending on the solvent and conditions used. Understanding its solubility is crucial for both theoretical studies and practical applications. Here are some key points to consider:

  • Polarity: Due to the presence of an amino group (-NH2) and a chloro substituent, the compound exhibits a degree of polarity which can influence its solubility in water.
  • Solvents: Typically, this compound may show better solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO) compared to aqueous environments.
  • pH Effects: The solubility of this amine may be enhanced in acidic conditions due to potential protonation of the amine, facilitating interactions with water molecules.
  • Temperature: Increasing temperature often enhances the solubility of organic compounds, which can be relevant in formulation processes.

In conclusion, while 1-(6-chloro-1H-indol-3-yl)propan-2-amine may not exhibit high solubility in pure water, it can dissolve well in various organic solvents under appropriate conditions. Always consider the specific solvent characteristics and environmental factors when assessing solubility.

Interesting facts

Interesting Facts about 1-(6-chloro-1H-indol-3-yl)propan-2-amine

1-(6-chloro-1H-indol-3-yl)propan-2-amine, often referred to as a derivative of indole, is an intriguing example of a chemical compound steeped in rich bioactivity. Here are some fascinating aspects of this compound:

  • Indole Backbone: The compound features an indole structure, a core element known for its pivotal role in the realm of organic chemistry. Indoles are prominent in various natural products and significantly influence pharmacological activity.
  • Pharmacological Potential: Research suggests that compounds like 1-(6-chloro-1H-indol-3-yl)propan-2-amine exhibit promising properties, particularly in neuropharmacology. The indole ring can interact effectively with various neurotransmitter systems, potentially leading to therapeutic applications.
  • Chlorinated Framework: The presence of chlorine within the structure not only enhances the compound's reactivity but also modifies its biological activity. Chlorine atoms can dramatically influence how the compound interacts with biological targets, making it an area of interest for drug design.
  • Synthetic Versatility: The ability to synthesize this compound from simpler organic materials is a testament to the creativity and ingenuity of chemists. The construction of the indole and subsequent incorporation of the propan-2-amine group showcases the synthetic pathways that are often explored in medicinal chemistry.
  • Research Applications: Studies are continually being pursued to explore the compound's effects and mechanisms. It serves as a valuable tool for scientists in understanding complex biological systems and designing new therapeutic agents.

This compound exemplifies the blend of chemistry and biology, demonstrating how small structural modifications can profoundly impact the biological activity and application of a chemical compound. Its exploration remains a fascinating frontier for scientists!

Synonyms
712-10-7
1-(6-chloro-1H-indol-3-yl)propan-2-amine
DTXSID801276159
AKOS017560505
6-Chloro-I+/--methyl-1H-indole-3-ethanamine