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Corticosterone

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Identification
Molecular formula
C21H30ClO4
CAS number
50-22-6
IUPAC name
1-(6-chloro-3,17-dihydroxy-10,13-dimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)ethanone
State
State

Corticosterone is a solid at room temperature, appearing as crystalline or powdery forms, depending on its preparation.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
373.15
Boiling point (Kelvin)
646.30
General information
Molecular weight
346.90g/mol
Molar mass
346.9040g/mol
Density
1.3100g/cm3
Appearence

Corticosterone is typically a white to off-white solid that can appear crystalline in structure. It is odorless and hydrophobic, tending to clump together.

Comment on solubility

Solubility of 1-(6-chloro-3,17-dihydroxy-10,13-dimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)ethanone

The solubility characteristics of 1-(6-chloro-3,17-dihydroxy-10,13-dimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)ethanone can be intriguing to explore due to its complex structure. This compound exhibits unique solubility traits influenced by several factors:

  • Polarity: The presence of hydroxyl (-OH) groups generally enhances solubility in polar solvents such as water. However, the bulky hydrocarbon framework may counterbalance this effect, leading to varied solubility profiles.
  • Solvent Type: It is likely more soluble in organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO) compared to water. The extensive hydrophobic regions can hinder solvation in polar mediums.
  • Temperature Influence: Increased temperature can enhance solubility for many organic compounds, encouraging interactions with solvent molecules.

For practical applications, understanding the solubility of this compound is critical. It allows researchers to:

  • Predict behavior during chemical reactions.
  • Optimize extraction processes.
  • Facilitate formulation development in pharmaceuticals.

To summarize, solubility is a multifaceted property influenced by both molecular structure and environmental conditions. **"Mastering solubility can be the key to unlocking a compound's potential."** Thus, evaluating 1-(6-chloro-3,17-dihydroxy-10,13-dimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)ethanone's solubility will be essential for its effective utilization.

Interesting facts

Interesting Facts about 1-(6-chloro-3,17-dihydroxy-10,13-dimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)ethanone

This compound, known for its complex structure and intriguing properties, is a derivative of a steroidal framework. It belongs to a class of compounds that have garnered attention in both pharmacological and chemical research due to their potential biological activities.

Key Features

  • Chlorination: The presence of a chlorine atom at the 6-position plays a significant role in the compound's reactivity and biological activities, often enhancing potency compared to its non-chlorinated analogs.
  • Hydroxyl Groups: The two hydroxyl (-OH) groups located at the 3 and 17 positions contribute to its hydrophilicity and may facilitate interactions with biological targets, enhancing solubility in biological systems.
  • Methyl Substituents: The dimethyl groups at the 10 and 13 positions can influence conformational flexibility, which is critical in determining the compound’s binding affinities to various biological receptors.

Biological Relevance

The structural characteristics of this compound suggest potential applications in medicinal chemistry. It has been studied for various therapeutic effects, including:

  • Anti-inflammatory activities
  • Anticancer potential
  • Hormonal regulation and modulation

As noted by researchers, compounds like this one exemplify how structural modifications can lead to significant changes in biological activity. The exploration of analogs may ultimately yield compounds with enhanced efficacy and reduced side effects.

Research Insights

The ongoing research into this compound integrates diverse fields such as organic chemistry, biochemistry, and pharmacology. The complexity of its structure demands of chemists unique strategies for synthesis and analysis. This compound serves as a prime example of how intricate molecular architectures can combine various biological functionalities.

As you delve into the realm of steroid derivatives, this compound stands out as a fascinating subject for further exploration and study, highlighting the intricate dance between structure and function in medicinal chemistry.

Synonyms
DTXSID90864916
NS00126533
6-chloro-3,17-dihydroxypregna-4,6-dien-20-one