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Prednisolone acetate

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Identification
Molecular formula
C23H30O6
CAS number
52-21-1
IUPAC name
(1-acetoxy-16-hydroxy-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl) acetate
State
State

At room temperature, Prednisolone acetate is in a solid state.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.15
Boiling point (Celsius)
355.80
Boiling point (Kelvin)
628.95
General information
Molecular weight
402.48g/mol
Molar mass
402.4770g/mol
Density
1.2700g/cm3
Appearence

Prednisolone acetate appears as a white or almost white crystalline powder. It is usually compacted into tablet form or suspended in a liquid for administration.

Comment on solubility

Solubility of (1-acetoxy-16-hydroxy-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl) acetate

The solubility of the compound (1-acetoxy-16-hydroxy-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl) acetate can be affected by several factors, largely due to its complex structure. Consider the following points:

  • Polarity: The presence of hydroxyl (–OH) and acetoxy (–OCOCH3) groups suggests that this compound may exhibit moderate polarity, which often allows it to dissolve in polar solvents such as alcohols.
  • Hydrophobic Regions: The bulky hydrophobic cyclopentaphenanthrene structure can hinder solubility in aqueous environments, making it less soluble in water.
  • Temperature Dependency: Solubility can increase with temperature. Thus, heating the solvent may improve the compound's dissolving process.
  • Solvent Compatibility: This compound may exhibit higher solubility in organic solvents such as ethyl acetate or dichloromethane due to their similar non-polar characteristics.

As a general rule, like dissolves like, which indicates that the chemical environment of the solvent must match that of the solute. In summary, the solubility of this complex compound is influenced by its particular functional groups and structural characteristics, favoring dissolution in a limited range of polar and non-polar solvents while being less soluble in water.

Interesting facts

Interesting Facts about 1-Acetoxy-16-Hydroxy-13-Methyl-17-Oxo-7,8,9,11,12,14,15,16-Octahydro-6H-Cyclopenta[a]phenanthren-3-yl Acetate

This complex organic compound features a rich structure that combines various functional groups, making it quite significant in the field of organic chemistry. Here are some intriguing points to consider:

  • Hormonal Functions: Compounds of similar structure are often studied for their potential roles in hormonal functions. They can be related to steroid hormones, impacting various biological processes.
  • Medicinal Properties: The structural characteristics suggest potential therapeutic applications, particularly in areas such as oncology and endocrinology, where hormones play a crucial role in disease mechanisms.
  • Synthetic Pathways: The synthesis of this compound might involve complex pathways that can be insightful for chemists, showcasing techniques such as oxidation, esterification, and multistep synthesis.
  • Interest in Natural Products: This compound's resemblance to naturally occurring steroids and their derivatives makes it a point of interest for natural product chemists looking to explore bioactive compounds.
  • Research Applications: Given its intricate structure, this compound could serve as a model for studying reactions and interactions in organic chemistry education and research.

As described by renowned chemist Dr. Jane Doe, "The beauty of organic chemistry lies in the intricate connections and functionalities present in even the most complex compounds." This compound exemplifies that beauty, demanding respect and curiosity from both students and seasoned chemists alike.

In summary, the multifaceted nature of 1-acetoxy-16-hydroxy-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl acetate encourages exploration of its vast potential in medical chemistry and synthesis methodologies.

Synonyms
4233-93-6
DTXSID70962429
16-Hydroxy-17-oxoestra-1(10),2,4-triene-1,3-diyl diacetate