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Tolimidone

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Identification
Molecular formula
C9H13N3
CAS number
304-87-0
IUPAC name
1-amino-2-(p-tolylmethyl)guanidine
State
State

At room temperature, tolimidone is typically in a solid state, often appearing as a crystalline powder.

Melting point (Celsius)
119.00
Melting point (Kelvin)
392.15
Boiling point (Celsius)
456.00
Boiling point (Kelvin)
729.15
General information
Molecular weight
177.26g/mol
Molar mass
177.2580g/mol
Density
1.2040g/cm3
Appearence

Tolidine is typically found in the form of colorless crystals or crystalline powder.

Comment on solubility

Solubility of 1-amino-2-(p-tolylmethyl)guanidine

1-amino-2-(p-tolylmethyl)guanidine, a compound known for its unique structural features, presents intriguing characteristics regarding its solubility.

When examining its solubility, it is essential to consider the following factors:

  • Polarity: The presence of amino and guanidine functional groups may enhance the molecule's ability to interact with polar solvents.
  • Hydrophobic Regions: The p-tolylmethyl group introduces a hydrophobic character, which can lead to a lower solubility in water but an increased solubility in organic solvents.
  • pH Dependence: Solubility might also be influenced by the pH of the solution, given the presence of basic nitrogen atoms in the guanidine moiety.

Overall, it is often observed that 1-amino-2-(p-tolylmethyl)guanidine is moderately soluble in polar solvents such as water, while it may show enhanced solubility in non-polar organic solvents.

In conclusion, understanding the solubility of this compound requires an appreciation of the balance between its hydrophilic and hydrophobic components, making it a subject of interest for further study.

Interesting facts

Interesting Facts about 1-amino-2-(p-tolylmethyl)guanidine

1-amino-2-(p-tolylmethyl)guanidine is a fascinating compound that invites exploration and analysis in the field of chemistry. Here are some compelling details:

  • Structure and Function: This compound features a unique guanidine structure, which is crucial in various biological processes. Guanylate cyclase activation and nitric oxide signaling are influenced by similar compounds.
  • Pharmaceutical Relevance: Research has identified derivatives of guanidine compounds as potential therapeutic agents. Their roles in the treatment of conditions like hypertension and diabetes make them significant in medicinal chemistry.
  • Mechanism of Action: While the specific mechanism of 1-amino-2-(p-tolylmethyl)guanidine is still under investigation, compounds with similar structures are known to potentially modulate nitric oxide synthesis, critical in cardiovascular health.
  • Research Applications: Scientists are continually exploring its applications in biological and chemical research settings. Its ability to act as a nitric oxide donor opens up possibilities for studying various physiological effects.
  • Analytical Techniques: Investigating this compound typically involves advanced techniques, including NMR (Nuclear Magnetic Resonance) and HPLC (High-Performance Liquid Chromatography), enabling thorough characterization and purity assessments.

As a thought-provoking compound, 1-amino-2-(p-tolylmethyl)guanidine exemplifies how small structural changes can lead to significant biological impacts, making it an interesting subject of study for chemists and biochemists alike. As the research progresses, further insights into its properties and applications may redefine its importance in scientific investigation.

Synonyms
SCHEMBL10591756
AKOS006340113
AKOS017407193