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Ranitidine hydrochloride

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Identification
Molecular formula
C13H23ClN4O3S
CAS number
66357-59-3
IUPAC name
1-[amino-(4-chloroanilino)methylene]-2-isopropyl-guanidine;hydrochloride
State
State

At room temperature, ranitidine hydrochloride is usually in a solid state. It is commonly used in its solid form as tablets or granules for medications.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.00
Boiling point (Celsius)
240.00
Boiling point (Kelvin)
513.00
General information
Molecular weight
350.87g/mol
Molar mass
350.8680g/mol
Density
1.3008g/cm3
Appearence

Ranitidine hydrochloride typically appears as a white to pale yellow, crystalline powder. It may also be found in granulated or powder form for pharmaceutical formulations. The compound is hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 1-[amino-(4-chloroanilino)methylene]-2-isopropyl-guanidine; hydrochloride

The solubility of 1-[amino-(4-chloroanilino)methylene]-2-isopropyl-guanidine; hydrochloride is of particular interest due to its chemical structure and the presence of the hydrochloride moiety. Generally, compounds belonging to the guanidine class tend to exhibit varying degrees of solubility in water, largely influenced by their functional groups.

  • Hydrochloride Form: The formation of the hydrochloride salt typically enhances solubility in aqueous media compared to its free base form.
  • Polarity: The balance between hydrophobic (from the isopropyl group) and hydrophilic (from the guanidine and amino groups) characteristics plays a crucial role in solubility.
  • Temperature Dependence: As with many soluble salts, solubility can increase with temperature, making it an important factor in practical applications.

Furthermore, the solubility behavior can be summarized through key points:

  1. Expected water solubility: Likely significant, however, specific solubility measurements may vary.
  2. Influence of pH: The solubility may change in different pH environments, particularly due to the presence of the guanidine group.
  3. Interaction with biological systems: Its solubility can affect bioavailability in pharmaceutical contexts.

In conclusion, the solubility of 1-[amino-(4-chloroanilino)methylene]-2-isopropyl-guanidine; hydrochloride is crucial for its applications, with several factors influencing its behavior in solution.

Interesting facts

Interesting Facts about 1-[amino-(4-chloroanilino)methylene]-2-isopropyl-guanidine; hydrochloride

This compound, also known as a derivative of guanidine, exhibits unique properties that make it valuable in various scientific applications. Below are some captivating aspects to consider:

  • Biological Activity: The structure of this compound suggests it may interact with biological pathways, potentially acting as a modulator in certain enzymatic processes.
  • Pharmaceutical Relevance: Due to its guanidine core, it could have implications in drug design, particularly for conditions requiring modulation of nitric oxide pathways or in treatments involving cardiovascular health.
  • Chlorine Substitution: The presence of the chlorine atom enhances the compound's reactivity and water-solubility, which is often a crucial factor in drug formulation and delivery.
  • Potential as a Research Tool: Scientists exploring the relationship between structure and biological activity might find this compound an interesting subject for studies in medicinal chemistry.

As a scientist or chemistry student, understanding the nuances of such compounds is essential. They not only contribute to medicinal chemistry but also help in deciphering complex biological interactions. As the renowned chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas," and compounds like this can spark innovative thoughts in both research and application.


Always consider the ethical implications and regulatory guidelines associated with the use of such compounds in biological and medicinal research. The journey from laboratory synthesis to practical application can be just as fascinating as the chemistry itself!

Synonyms
Proguanil hydrochloride
637-32-1
(1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;hydrochloride
N1-(4-Chlorophenyl)-N5-isopropylbiguanide Hydrochloride
DTXSID7047776
MFCD01732193
1189671-34-8
MLS002154090
AC6521
FC19929
SMR001233398
SY047809
NS00079833
N1-(4-Chlorophenyl)-N5-isopropylbiguanide HCl
Q27287873
N-(4-Chlorophenyl)-N'-(1-methylethyl)-imidodicarbonimidic diamide hydrochloride;1-(p-Chlorophenyl)-5-isopropylbiguanide hydrochlorid e