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Phenylthiourea

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Identification
Molecular formula
C8H8N2S
CAS number
103-85-5
IUPAC name
1-[amino(sulfanyl)methylene]-3-phenyl-isothiourea
State
State

At room temperature, phenylthiourea is in a solid state, particularly in its crystalline form.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
255.00
Boiling point (Kelvin)
528.15
General information
Molecular weight
152.23g/mol
Molar mass
152.2400g/mol
Density
1.3240g/cm3
Appearence

Phenylthiourea is a white crystalline solid with no distinctive odor. It is primarily available in powder form and has a bitter taste. The compound is sensitive to light and may slowly change color upon prolonged exposure.

Comment on solubility

Solubility of 1-[amino(sulfanyl)methylene]-3-phenyl-isothiourea

The solubility of 1-[amino(sulfanyl)methylene]-3-phenyl-isothiourea can vary due to the presence of functional groups that influence its interaction with solvents. This compound features both amino and thioketone groups, which can significantly affect its solubility properties.

Factors Influencing Solubility

  • Polar vs. Non-Polar Solvents: The polar nature of the amino group may lead to better solubility in polar solvents such as water or alcohols.
  • Hydrogen Bonding: The potential for hydrogen bonding due to the amino group can enhance solubility in aqueous solutions.
  • Structural Configuration: The phenyl group may decrease solubility in polar solvents while increasing it in non-polar solvents due to its hydrophobic nature.

It is often observed that compounds containing both hydrophilic and hydrophobic parts may show a peculiar phenomenon known as amphiphilicity, where they could have some solubility in a range of solvents but might precipitate in others under specific conditions.

While specific solubility data for 1-[amino(sulfanyl)methylene]-3-phenyl-isothiourea may not be readily available, it is essential to conduct experimental assessments to determine its solubility profile accurately. In conclusion, understanding the solubility characteristics of this compound is crucial for its applications in various chemical environments.

Interesting facts

Interesting Facts about 1-[amino(sulfanyl)methylene]-3-phenyl-isothiourea

1-[amino(sulfanyl)methylene]-3-phenyl-isothiourea is a fascinating compound that invites considerable attention in the fields of medicinal chemistry and drug discovery due to its unique chemical structure. Here are some intriguing facts about this compound:

  • Dual Functional Groups: The presence of both isothiourea and sulfanyl functional groups in this compound contributes to its diverse reactivity and potential applications in organic synthesis.
  • Biological Activity: Compounds with isothiourea moieties are known for their significant pharmaceutical properties, including anticancer, antifungal, and antimicrobial activities, making this compound a candidate for further biological evaluation.
  • Role in Research: Researchers are particularly interested in isothioureas for their ability to act as versatile intermediates in the development of new drugs. Their unique reactivity can lead to novel therapeutic agents.
  • Synthetic Utility: This compound can be synthesized through various methods, including one-pot reactions, which highlight its accessibility for laboratory work and research purposes.
  • Intrigued Chemists: The structural complexity of 1-[amino(sulfanyl)methylene]-3-phenyl-isothiourea continues to captivate the attention of chemists, and many are exploring its potential interactions with biological targets.

In summary, 1-[amino(sulfanyl)methylene]-3-phenyl-isothiourea represents a unique intersection of structure and function, amplifying interest in its synthesis and biological implications. With ongoing research, this compound may unlock avenues for new therapies and foster advancements in medicinal chemistry.