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1-Azaspiro[4.5]decane

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Identification
Molecular formula
C9H17N
CAS number
19686-71-4
IUPAC name
1-azaspiro[4.5]decane
State
State

At room temperature, 1-Azaspiro[4.5]decane is a liquid. This state, coupled with its odor, should be handled in well-ventilated areas or under a fume hood.

Melting point (Celsius)
-37.00
Melting point (Kelvin)
236.15
Boiling point (Celsius)
184.00
Boiling point (Kelvin)
457.15
General information
Molecular weight
139.23g/mol
Molar mass
139.2340g/mol
Density
0.8975g/cm3
Appearence

1-Azaspiro[4.5]decane typically appears as a colorless or light-yellow liquid. It has a distinct amine odor characteristic of nitrogen-containing compounds.

Comment on solubility

Solubility of 1-azaspiro[4.5]decane

1-azaspiro[4.5]decane is a compound whose solubility can be influenced by various factors. Understanding its solubility properties is crucial for numerous applications, particularly in the pharmaceutical field. Here are some key points to consider:

  • Solvent Polarity: The solubility of 1-azaspiro[4.5]decane is likely to be affected by the polarity of the solvent. As a general rule, "like dissolves like," meaning nonpolar solvents might better solvate this compound compared to polar solvents.
  • Temperature Effects: The temperature can also play a significant role in solubility. Typically, increasing the temperature tends to increase the solubility of solids in liquids, so experiments conducted at varied temperatures can yield interesting results.
  • Intramolecular Forces: Intramolecular interactions within the 1-azaspiro[4.5]decane structure might limit its ability to dissolve in certain media. Compounds with stronger intermolecular forces often exhibit lower solubility in solvents that do not match these forces.
  • Practical Use: For practical applications, knowing its solubility in common solvents can help in formulating effective drug delivery systems or aligning it with other chemicals in a reaction.

In summary, predicting the solubility of 1-azaspiro[4.5]decane requires considering multiple factors, and empirical data is often necessary to draw accurate conclusions. Understanding its solubility behavior opens new pathways for innovative chemical applications.

Interesting facts

Interesting Facts About 1-Azaspiro[4.5]decane

1-Azaspiro[4.5]decane is a fascinating compound that falls under the category of spiro compounds, characterized by the presence of a nitrogen atom within a multi-cyclic structure. This compound has garnered attention due to its unique structural features and potential applications.

Unique Structural Characteristics

  • Azaspiro Structure: The 'aza' prefix indicates the presence of a nitrogen atom in the spirocyclic framework, which can significantly influence the compound's properties and reactivity.
  • Chirality: 1-Azaspiro[4.5]decane is chiral, meaning it can exist in two non-superimposable mirror forms. This property holds significant importance in drug development and synthesis.

Applications and Significance

  • Pharmaceutical Potential: Due to the unique structure, 1-azaspiro[4.5]decane may serve as a scaffold for developing novel pharmaceuticals, particularly in the context of modifying neurological conditions or enhancing cognitive functions.
  • Research Tool: It can act as a crucial intermediate or building block in organic synthesis, leading to the discovery of other biologically active compounds.

Quotes from the Field

As noted by chemists exploring spiro compounds, "The integration of nitrogen in a spirocyclic framework opens new pathways for medicinal chemistry, enabling the design of compounds with enhanced selectivity and efficacy."

Conclusion

In summary, 1-azaspiro[4.5]decane stands out due to its structural intricacies, potential applications in drug development, and its role in advancing aromatic compound research. Its unique features continue to intrigue both researchers and students alike within the field of organic chemistry.

Synonyms
1-Azaspiro[4.5]decane
176-80-7
1-Aza-spiro[4.5]decane
1-AZASPIRO(4.5)DECANE
2,2-Pentamethylenepyrrolidine
NSC 19984
BRN 0103872
NSC19984
CHEMBL3753828
DTXSID10170061
354S34PWD9
5-20-04-00400 (Beilstein Handbook Reference)
NSC-19984
4-azaspiro[4.5]decane
MFCD01665114
{1-Azaspiro[4.5]decane}
SCHEMBL162968
UNII-354S34PWD9
DTXCID8092552
WLN: T5NXTJ B-& AL6XTJ
AAA17680
BDBM50137089
AKOS006277627
SB34297
Pyrrolidine, 2,2-(1,5-pentanediyl)-
AS-32866
DB-126833
CS-0340065
EN300-98626
966-415-2