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1-benzoyl-2H-quinoline-2-carbonitrile

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Identification
Molecular formula
C17H10N2O
CAS number
64639-22-7
IUPAC name
1-benzoyl-2H-quinoline-2-carbonitrile
State
State

At room temperature, 1-benzoyl-2H-quinoline-2-carbonitrile exists in a solid state. Its crystalline form is characteristic of compounds with extensive aromaticity, contributing to its stability and distinct physical properties.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
258.28g/mol
Molar mass
258.2830g/mol
Density
1.2500g/cm3
Appearence

This compound typically appears as a crystalline solid, with a nuanced shade ranging from colorless to pale yellow. The precise color depends on the purity of the compound and specific synthesis methods.

Comment on solubility

Solubility of 1-benzoyl-2H-quinoline-2-carbonitrile

1-benzoyl-2H-quinoline-2-carbonitrile exhibits unique solubility characteristics that can vary widely depending on the solvent used. Here are some key points regarding its solubility:

  • Solvent Dependence: This compound tends to be more soluble in organic solvents, such as dichloromethane and dimethyl sulfoxide (DMSO), rather than in polar solvents like water.
  • Nonpolar and Polar Solvents: Its solubility improves in less polar environments. For instance, it might show limited solubility in medium-polar solvents, like ethanol, which can be useful in certain applications.
  • Temperature Influence: The solubility may also be temperature-dependent, indicating that higher temperatures could enhance the solvation of the compound in suitable solvents.
  • Impurities and Interactions: The presence of other substances can impact solubility, as interactions with solutes might cause solidification or precipitation.

Given its relatively low water solubility, scientists often recommend performing solubility tests in organic mediums to facilitate the dissolution process. As always, understanding the solvent properties is crucial for predicting the behavior of 1-benzoyl-2H-quinoline-2-carbonitrile in various experimental conditions.

Interesting facts

Interesting Facts about 1-benzoyl-2H-quinoline-2-carbonitrile

1-benzoyl-2H-quinoline-2-carbonitrile is a fascinating organic compound that holds significant interest in both synthetic chemistry and medicinal research. This compound is characterized by its unique structure which comprises a quinoline backbone, a benzoyl group, and a nitrile functional group.

Chemical Structure and Features

The structure of 1-benzoyl-2H-quinoline-2-carbonitrile contributes to its reactivity and interactions with other molecules. Here are some intriguing features:

  • Quinoline Core: The quinoline moiety enhances the compound's chemical stability and makes it a versatile building block for further chemical modifications.
  • Benzoyl Group: The presence of the benzoyl group often leads to increased lipophilicity, which is beneficial for drug development as it can affect the membrane permeability of the compound.
  • Nitrile Function: The nitrile (-C≡N) group can engage in various reactions, making it a valuable functional group in organic synthesis.

Applications in Research

Researchers have shown a keen interest in this compound due to its potential applications:

  • Pharmaceutical Development: Compounds with quinoline structures have been noted for their biological activities, including antimalarial, antiviral, and anticancer properties.
  • Material Science: The functionalization of quinoline derivatives can be useful in creating novel materials with specific electronic properties.
  • Fluorescent Probes: Some derivatives of this compound have been explored as fluorescent probes in biochemical assays, enhancing detection capabilities.

In conclusion, 1-benzoyl-2H-quinoline-2-carbonitrile serves as an excellent example of how specific structural features can lead to diverse applications in chemistry and beyond. Its significant potential in various fields highlights the importance of exploring intricate organic compounds across industries.

Synonyms
1-Benzoyl-1,2-dihydro-2-quinolinecarbonitrile
1-Benzoyl-2-cyano-1,2-dihydroquinoline
Quinaldonitrile, 1-benzoyl-1,2-dihydro-
NSC 11908
2-Quinolinecarbonitrile, 1-benzoyl-1,2-dihydro-
BRN 0232716
2-QUINOLINECARBONITRILE, 1,2-DIHYDRO-1-BENZOYL-
5-22-03-00051 (Beilstein Handbook Reference)
Quinaldonitrile, 1-benzoyl-1,2-dihydro-(8CI)
2-Quinolinecarbonitrile, 1-benzoyl-1,2-dihydro-(9CI)
665-891-6
13721-17-0
1-benzoyl-1,2-dihydroquinoline-2-carbonitrile
1-benzoyl-2H-quinoline-2-carbonitrile
1-Benzoyl-1,2-dihydroquinaldonitrile
MLS000718165
SMR000279933
1-(phenylcarbonyl)-1,2-dihydroquinoline-2-carbonitrile
NSC11908
Maybridge1_007249
Quinaldonitrile,2-dihydro-
Oprea1_421957
Oprea1_454907
cid_26219
SCHEMBL8342494
CHEMBL1522307
BDBM60322
HMS562B11
DTXSID801035909
HMS2749J19
2-Quinolinecarbonitrile,2-dihydro-
CCG-53178
NSC-11908
STK087341
AKOS002353577
AKOS016111279
SB71436
SDCCGSBI-0660196.P001
NCGC00245468-01
CS-0358090
ST50223295
2-Quinolinecarbonitrile,2-dihydro-1-benzoyl-
1-(phenylcarbonyl)-2H-quinoline-2-carbonitrile
1-(Benzoyl)-1,2-dihydro-quinoline-2-carbonitrile
AH-357/02156030
SR-01000642359-1