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1-Benzyl-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)indole

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Identification
Molecular formula
C20H22N2
CAS number
135463-81-9
IUPAC name
1-benzyl-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)indole
State
State

At room temperature, this compound is generally a solid.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
286.41g/mol
Molar mass
286.3870g/mol
Density
1.1850g/cm3
Appearence

This compound typically appears as a solid at room temperature. It may be presented as a crystalline or amorphous structure depending on its purity and specific preparation methods.

Comment on solubility

Solubility of 1-benzyl-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)indole

The solubility of 1-benzyl-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)indole is a complex topic due to its unique chemical structure. Understanding its solubility can help in various applications, especially in pharmaceuticals and materials science.

Key Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups can significantly enhance solubility in polar solvents, while nonpolar sections may favor solubility in nonpolar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can greatly increase solubility in water. Compounds capable of donating or accepting hydrogen bonds generally dissolve more readily.
  • Temperature: Increasing temperature often boosts solubility, although this can vary depending on the compound and solvent used.
  • pH Levels: For compounds with ionizable groups, altering the pH can change the solubility profile, making the compound more or less soluble.

In general, the solubility of similar indoles tends to be mediocre in aqueous environments but much better in organic solvents due to their aromatic nature. Therefore, it is reasonable to conclude that 1-benzyl-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)indole may primarily exhibit moderate to low solubility in water, while being more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).

Understanding the solubility characteristics of this compound is crucial for optimizing formulations in drug development and ensuring efficacy in biological systems.

Interesting facts

Interesting Facts about 1-benzyl-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)indole

This compound is a fascinating member of the indole family, which has captured the attention of chemists due to its diverse applications in medicinal chemistry. Here are some noteworthy points:

  • Biological Activity: Compounds related to indole structures are often noted for their considerable pharmacological properties, ranging from anti-cancer to anti-inflammatory effects. This specific compound may exhibit unique bioactivity due to the presence of both benzyl and pyridinyl moieties.
  • Structural Versatility: The fusion of a benzyl group with an indole and pyridine offers a flexible scaffold for medicinal chemistry. This versatility allows for the design of new derivatives that can enhance therapeutic efficacy.
  • Research Interest: As a synthetic intermediate, the compound is of interest in ongoing research aimed at developing novel drugs and understanding complex biological pathways. Its unique structure presents potential targets in enzyme inhibition or receptor modulation.
  • Mechanistic Studies: The integration of a dihydropyridine within the structure opens doors for investigations into *redox behavior*. Such studies can lead to a deeper understanding of electron transfer processes, which are crucial in many biochemical reactions.

The study of 1-benzyl-2-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)indole highlights the intersection of organic chemistry and pharmacology, demonstrating how nuanced chemical structures can lead to significant advancements in therapeutic agents. Emphasizing the motto “*Structure dictates function*,” researchers are eager to probe this compound’s full potential.

Synonyms
BRN 0962037
INDOLE, 1-BENZYL-2-(1,2,5,6-TETRAHYDRO-1-METHYL-3-PYRIDYL)-
25905-61-7
1-Benzyl-2-(1,2,5,6-tetrahydro-1-methyl-3-pyridyl)-indole
DTXSID60180574
5-23-08-00113 (Beilstein Handbook Reference)
RefChem:349153
DTXCID00103065