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Cyclamate

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Identification
Molecular formula
C6H12NO3S
CAS number
100-88-9
IUPAC name
1-benzyl-3-(1-methylpyrrolidin-1-ium-2-yl)indole;N-cyclohexylsulfamate
State
State

At room temperature, cyclamate is generally found in a solid state.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.00
Boiling point (Celsius)
270.00
Boiling point (Kelvin)
543.00
General information
Molecular weight
201.24g/mol
Molar mass
201.2400g/mol
Density
1.3400g/cm3
Appearence

Cyclamate typically appears as a white, crystalline powder. It is water-soluble and is known for its sweet taste, which is why it is often used as an artificial sweetener in the form of its sodium or calcium salts.

Comment on solubility

Solubility of 1-benzyl-3-(1-methylpyrrolidin-1-ium-2-yl)indole; N-cyclohexylsulfamate

The solubility of the compound 1-benzyl-3-(1-methylpyrrolidin-1-ium-2-yl)indole; N-cyclohexylsulfamate can be described as quite complex, primarily due to its unique structural features. Here are some key points regarding its solubility:

  • Apolar characteristics: The presence of the benzyl and cyclohexyl groups tends to impart hydrophobic properties, potentially reducing solubility in polar solvents.
  • Ionic form: The pyrrolidin-1-ium moiety indicates that this compound can exist in an ionic form, which may enhance its solubility in polar solvents such as water or methanol compared to its neutral counterparts.
  • Intermolecular interactions: The ability to form hydrogen bonds due to the amine and sulfonamide group enhances solubility in certain solvents, especially those that can act as hydrogen bond donors.
  • Solvent dependence: It is important to note that the solubility will vary significantly with solvent choice. For example, high dielectric constant solvents might better accommodate the ionic characteristics of this compound.

In summary, the solubility of this compound is influenced by a combination of its ionic nature, hydrophobic regions, and the ability to engage in hydrogen bonding. As with many organic compounds, a systematic approach to solubility testing in various solvents is recommended to ascertain its practical applications.

Interesting facts

Interesting Facts about 1-benzyl-3-(1-methylpyrrolidin-1-ium-2-yl)indole; N-cyclohexylsulfamate

1-benzyl-3-(1-methylpyrrolidin-1-ium-2-yl)indole; N-cyclohexylsulfamate is a compound that showcases the fascinating intersection of organic chemistry, medicinal chemistry, and pharmacology. Here are some intriguing aspects of this compound:

  • Complex Structure: The molecule combines an indole moiety with a pyrrolidinium structure, making it an interesting subject for studies in both synthetic and analytical chemistry.
  • Psychoactive Properties: Indole derivatives are often linked to psychoactive effects. This compound's intricate assembly suggests potential interactions with neurotransmitter systems, which could have implications for drug development.
  • Application in Medicinal Chemistry: Compounds containing the sulfamate functional group are known for their biological activity. The N-cyclohexylsulfamate portion may contribute to this compound's activity in various therapeutic areas.
  • Involvement in Drug Actions: The presence of a benzylic group and a pyrrolidin-1-ium might enhance solubility and bioavailability, critical parameters for drug efficacy.
  • Research Opportunities: Due to the novelty of its structure, this compound presents ample opportunities for research in drug formulation and design, particularly in the realm of targeting neural pathways.

As one delves deeper into the study of this compound, it becomes evident that its complex architecture harbors a wealth of possibilities for unraveling new chemical behaviors and therapeutic potentials. In the words of a celebrated chemist, "Chemistry is about the connections we make, both in molecules and in minds." Thus, exploring the intricacies of 1-benzyl-3-(1-methylpyrrolidin-1-ium-2-yl)indole; N-cyclohexylsulfamate could lead to groundbreaking insights in the world of pharmacological research!

Synonyms
1-Benzyl-3-(1-methyl-2-pyrrolidinyl)indole cyclohexanesulfamate
20465-89-8
INDOLE, 1-BENZYL-3-(1-METHYL-2-PYRROLIDINYL)-, MONO(CYCLOHEXANESULFAMATE)