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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
[1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate
State
State

At room temperature, Loperamide is in a solid state.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
477.40
Boiling point (Kelvin)
750.55
General information
Molecular weight
477.03g/mol
Molar mass
477.0340g/mol
Density
1.1900g/cm3
Appearence

Loperamide appears as a white or off-white crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl propanoate

The solubility of a compound is a crucial property that determines its behavior in various environments, especially in biological and chemical systems. For 1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl propanoate, several factors influence its solubility:

  • Polarity: The polarity of the compound plays a significant role in its solubility in aqueous solutions. This compound contains both non-polar (aromatic) and polar (dimethylamino) functional groups, which suggests moderate solubility in polar solvents.
  • Hydrogen Bonding: The ability of the dimethylamino group to participate in hydrogen bonding can enhance solubility in water and alcohols, rendering it soluble to certain extents in these solvents.
  • Temperature Dependency: Solubility often changes with temperature. Higher temperatures may increase solubility for organic compounds, making propanoate potentially more soluble when heated.
  • Structural Complexity: The complex structure may lead to varied solubility behavior in different solvents, indicating potential solubility in aprotic solvents as well.

In conclusion, while one might expect the solubility of a compound like 1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl propanoate to be substantial in polar solvents, the presence of bulkier non-polar sections may limit its overall solubility in water. Hence, understanding the solubility of this compound requires consideration of multiple factors, including structure, temperature, and solvent choice.

Interesting facts

Interesting Facts about 1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl propanoate

1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl propanoate is a fascinating compound with a variety of applications in the field of chemistry and pharmacology. Here are some intriguing aspects of this compound:

  • Structural Complexity: This compound features a complex molecular structure that includes amine and ester functional groups. The presence of a dimethylamino group adds an intriguing dimension to its reactivity.
  • Biological Activity: Compounds with similar structures often exhibit significant biological activity, making them potential candidates for drug development. They may interact with neurotransmitter systems, potentially influencing behaviors or treating diseases.
  • Drug Design: The unique combination of benzyl and propyl groups can be essential in ligand development for various receptors, enhancing the specificity and efficacy of potential pharmacological agents.
  • Research Potential: Given its structure, this compound serves as an excellent base for research into new chemical syntheses and the design of novel therapeutic agents.
  • Chemical Properties: The ability of the dimethylamino group to act as a base might lend itself to interesting acid-base reactions, making it a useful intermediate in organic synthesis.

As a chemistry student or a scientist working with this compound, one would find it valuable to explore its reactivity in various conditions to fully understand its potential applications. This compound embodies the intersection between organic chemistry and pharmacology, offering an exciting avenue for further investigation.

Synonyms
77-50-9
CHEBI:77401
[4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl] propanoate
Propoxyphene, dl-
2-BUTANOL, 4-(DIMETHYLAMINO)-3-METHYL-1,2-DIPHENYL-, PROPIONATE (ester)
Levopropoxyphen
DL-propoxyphene
Propoxyphenhydrochlorid
1,2-Diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutane
4-(Dimethylamino)-3-methyl-1,2-diphenyl-2-butanol propionate
alpha-4-Dimethylamino-3-methyl-1,2-diphenyl-2-butanolpropionate
alpha-4-Dimethylamino-1,2-diphenyl-3-methyl-4-propionyloxybutane
alpha-N,N-Dimethyl-3,4-diphenyl-2-methyl-3-propionoxy-1-butylamine
1,2-Difenyl-4-dimethylamino-3-methyl-2-butylester kyseliny propionove [Czech]
Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, propanoate (ester)
Propionic acid, alpha-(2-dimethylamino-1-methylethyl)-alpha-phenylphenethyl ester
SCHEMBL25406
1-Benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propionate #
CHEMBL300117
DTXSID60859379
Benzeneethanol, .alpha.-[2-(dimethylamino)-1-methylethyl]-.alpha.-phenyl-, propanoate (ester), [S-(R*,S*)]-
1,2-Difenyl-4-dimethylamino-3-methyl-2-butylester kyseliny propionove
PDSP1_001243
PDSP2_001227
FD35497
Benzeneethanol, .alpha.-[2-(dimethylamino)-1-methylethyl]-.alpha.-phenyl-, propanoate (ester)
AB00514748
NS00010430
L001219
BRD-A54635441-078-09-1
Q23766565
4-(dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propanoate