Skip to main content

Loperamide Hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C29H34ClN3O2
CAS number
34552-83-5
IUPAC name
[1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate;hydrochloride
State
State

At room temperature, loperamide hydrochloride is a solid. It is typically encountered in this solid form as a medication in tablet or capsule format.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
513.49g/mol
Molar mass
513.4990g/mol
Density
1.1900g/cm3
Appearence

Loperamide hydrochloride is a white or almost white crystalline powder, which is practically insoluble in water and only slightly soluble in ethanol. It has no odor and a slightly bitter taste.

Comment on solubility

Solubility of [1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate;hydrochloride

The solubility of a compound can significantly influence its applications and effectiveness, especially in pharmacology and biochemistry. For [1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate;hydrochloride, its solubility characteristics are crucial to understand due to the presence of both hydrophobic and hydrophilic sections within its molecular structure.

Factors Influencing Solubility

  • Ionic Nature: As a hydrochloride salt, the compound is likely to exhibit good solubility in aqueous solutions due to its ionic characteristics.
  • Polarity: The presence of the dimethylamino group enhances the compound's polarity, promoting solubility in polar solvents.
  • Hydrophobic Interactions: The benzyl and phenyl groups may lead to reduced solubility in non-polar solvents, creating a balance between polar and non-polar characteristics.

It is often stated that "like dissolves like," meaning that the solubility of this compound will generally be better in polar solvents such as water compared to non-polar organic solvents.

Expected Solubility

In practical applications, one can anticipate:

  • Moderate to high solubility in water due to the ionic nature of the hydrochloride form.
  • Limited solubility in non-polar organic solvents, which could hinder its use in some formulations.
  • Enhanced solubility in alcohols and other polar protic solvents that can interact favorably with the functional groups present.

Understanding the solubility profile of [1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl] propanoate;hydrochloride is vital for both its synthesis and its subsequent applications in medicinal chemistry and pharmacology.

Interesting facts

Interesting Facts about 1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl propanoate; hydrochloride

This compound, an organic salt, showcases intriguing characteristics that make it a subject of interest in both pharmaceutical and chemical sciences. Here are some noteworthy points:

  • Pharmaceutical Potential: Due to its structural properties, this compound may exhibit biological activity, making it a candidate for research in drug development. Its ability to interact with biological systems can lead to potential therapeutic uses.
  • Amine Functionality: The presence of the dimethylamino group is significant. Amines are critical in many chemical reactions and can behave as bases. This property contributes to the compound's reactivity and potential applications in synthesize other compounds.
  • Structural Complexity: The combination of benzyl, phenyl, and propyl groups creates a unique three-dimensional structure. This complexity can influence the compound's properties, such as solubility and reactivity.
  • Hydrochloride Form: The hydrochloride salt form enhances the solubility of the compound in aqueous solutions, which is beneficial for pharmacological research and applications.
  • Applications in Neuroscience: Compounds like this one could be studied for their influence on neurotransmitter receptors or other neurological pathways, possibly leading to advancements in treatments for mental health disorders.

In conclusion, the intriguing structure and potential biological activity of 1-benzyl-3-(dimethylamino)-2-methyl-1-phenyl-propyl propanoate; hydrochloride render it a fascinating subject for further scientific exploration. As research progresses, this compound may lead to new discoveries in medicinal chemistry.

Synonyms
4-(Dimethylamino)-3-methyl-1,2-diphenylbutan-2-yl propanoate--hydrogen chloride (1/1)
SCHEMBL41779
DTXSID60936134
DB-234183
95160-58-0