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Nitrofuran derivative

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Identification
Molecular formula
C13H10N4O4
CAS number
139-56-0
IUPAC name
1-(benzylideneamino)-3-[(5-nitro-2-furyl)methyleneamino]urea
State
State

At room temperature, the compound is in a solid state. It appears as a steady and stable crystalline solid under standard conditions.

Melting point (Celsius)
203.50
Melting point (Kelvin)
476.65
Boiling point (Celsius)
271.30
Boiling point (Kelvin)
544.45
General information
Molecular weight
344.24g/mol
Molar mass
344.2830g/mol
Density
1.4700g/cm3
Appearence

The compound appears as a yellow crystalline solid. It may exhibit a bright and vibrant hue due to the presence of the nitro and furyl groups.

Comment on solubility

Solubility of 1-(benzylideneamino)-3-[(5-nitro-2-furyl)methyleneamino]urea

The solubility of 1-(benzylideneamino)-3-[(5-nitro-2-furyl)methyleneamino]urea can be quite intriguing given its complex structure. This compound is characterized by the benzylidene and nitrofuran moieties, which impact its solubility in various solvents.

Key factors influencing the solubility include:

  • Polarity: The presence of polar functional groups, such as amino and nitro groups, affects how this compound interacts with solvents.
  • Hydrogen bonding: The amino groups can participate in hydrogen bonding, potentially increasing solubility in polar solvents like water.
  • Solvent type: This compound is likely more soluble in organic solvents such as DMSO or ethanol due to its hydrophobic benzylidene and furan components.

In general, solubility of organic compounds like this can vary significantly between polar and non-polar solvents. As noted, they might show notable solubility in:

  • Water: Moderate, depending on pH and temperature.
  • Organic solvents: High solubility in solvents such as dichloromethane (DCM) and ethanol.

To sum up, understanding the solubility of 1-(benzylideneamino)-3-[(5-nitro-2-furyl)methyleneamino]urea involves analyzing its molecular interactions with different solvents. Thus, it’s essential to consider both the functional groups and the solvent properties when predicting the solubility of this compound.

Interesting facts

Interesting Facts about 1-(Benzylideneamino)-3-[(5-Nitro-2-furyl)methyleneamino]urea

This particular compound, known as 1-(benzylideneamino)-3-[(5-nitro-2-furyl)methyleneamino]urea, is intriguing not only for its complex structure but also for its potential applications in the field of medicinal chemistry.

1. Structural Composition

The structure of this compound features interesting components that contribute to its properties and reactivity:

  • Benzylidene group: This part of the molecule enhances its stability and interaction with biological targets.
  • 5-Nitro-2-furyl moiety: Known for its electron-withdrawing effects, it increases the compound's reactivity in certain chemical reactions.
  • Urea fragment: This functional group is often associated with biological activity, especially in relation to enzyme inhibition.

2. Potential Biological Activities

Research has shown that compounds similar to this one often possess:

  • Anticancer properties: It demonstrates potential against various cancer cell lines due to its ability to interfere with specific biological pathways.
  • Antimicrobial effects: The unique structure may allow it to inhibit bacterial or fungal growth, making it valuable in medicinal applications.
  • Anti-inflammatory activity: Similar compounds are often investigated for their ability to reduce inflammation.

3. Synthesis and Modifications

The synthesis of 1-(benzylideneamino)-3-[(5-nitro-2-furyl)methyleneamino]urea involves:

  • Condensation reactions: These are key to forming the intricate network of functional groups present in the compound.
  • Modifications: Small changes in the substituents can lead to significant variations in biological activity, making it a subject of ongoing research.

4. Importance in Research

Due to its unique structure and potential biological activities, this compound serves as:

  • A lead compound: It can guide the design of new drugs with improved efficacy.
  • A tool for understanding: Researchers can study its interactions with biological macromolecules to gain insights into disease mechanisms.
  • Inspiration for similar compounds: It can inspire the synthesis of analogs with varied structures and functions.

As we delve deeper into the study of compounds like 1-(benzylideneamino)-3-[(5-nitro-2-furyl)methyleneamino]urea, we not only broaden our understanding of chemistry but also pave the way for new therapeutic advancements.