Tamoxifen | Solubility of Things

Identification

Molecular formula

C₂₆H₂₅BrFNO

CAS number

10540-29-1

IUPAC name

1-benzyloxy-4-[2-bromo-2-(2-fluorophenyl)-1-phenyl-vinyl]benzene

State

The compound is typically solid at room temperature.

Melting point (Celsius)

140.00

Melting point (Kelvin)

413.15

Boiling point (Celsius)

527.56

Boiling point (Kelvin)

800.71

General information

Molecular weight

371.49g/mol

Molar mass

371.4940g/mol

Density

1.1344g/cm³

Appearence

Tamoxifen typically appears as a white to off-white powder.

Comment on solubility

Solubility of 1-benzyloxy-4-[2-bromo-2-(2-fluorophenyl)-1-phenyl-vinyl]benzene

The solubility of 1-benzyloxy-4-[2-bromo-2-(2-fluorophenyl)-1-phenyl-vinyl]benzene is a complex subject that can depend on a variety of factors. Due to its intricate structure and multiple functional groups, this compound displays specific solubility characteristics that can be summarized as follows:

Solvent Interaction: This compound is likely to show variable solubility in organic solvents, such as dichloromethane or acetone, but may exhibit limited solubility in polar solvents like water due to its hydrophobic regions.
Temperature Influence: As with many organic compounds, solubility can be significantly influenced by temperature; typically, increasing the temperature enhances solubility.
Structural Factors: The presence of bulky aromatic groups and halogen substituents (bromo and fluoro) can introduce steric hindrance, potentially leading to lower solubility in certain solvents.

When considering its use in various chemical reactions or applications, it’s essential to remember that solubility may vary based on the conditions and chosen solvent. As a rule of thumb, a good practice is to conduct preliminary solubility tests to ascertain the best solvent system for the compound in question.

In summary, while predicting the solubility of 1-benzyloxy-4-[2-bromo-2-(2-fluorophenyl)-1-phenyl-vinyl]benzene can be intricate, careful consideration of the aforementioned factors can lead to a better understanding of its behavior in different environments.

Interesting facts

Interesting Facts about 1-Benzyloxy-4-[2-bromo-2-(2-fluorophenyl)-1-phenyl-vinyl]benzene

This compound is a fascinating example of organic chemistry with several intriguing aspects:

Structural Complexity: The presence of multiple aromatic rings and substituents indicates a complex structure, which can influence its reactivity and properties significantly.
Potential in Medicinal Chemistry: Compounds like this often serve as intermediates in the synthesis of pharmaceuticals, especially due to the presence of halogen atoms (such as bromine and fluorine) which can enhance biological activity. It is believed that such modifications can lead to improved binding affinities in drug design.
Influence of Substituents: The substitution patterns, specifically the bromo and fluoro groups, can play a crucial role in altering electronic properties. For example, fluorine atoms can modulate electron density, impacting how the molecule interacts with biological targets.
Synthetic Pathways: The synthesis of 1-benzyloxy-4-[2-bromo-2-(2-fluorophenyl)-1-phenyl-vinyl]benzene can involve various synthetic strategies, including electrophilic aromatic substitution and coupling reactions, showcasing the versatility of organic reactions.

"Chemistry is the simplest science; it is only the compounds that are complex." This quote captures the essence of working with intricate molecules such as this one.

Overall, 1-benzyloxy-4-[2-bromo-2-(2-fluorophenyl)-1-phenyl-vinyl]benzene illustrates not only the beauty of organic structure but also its potential impact in the world of pharmacology and materials science. Understanding its properties and reactions offers valuable insights into the development of new compounds that could lead to advancements in various chemical applications.