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1-Bromo-4-fluorobutane

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Identification
Molecular formula
C4H8BrF
CAS number
762-49-2
IUPAC name
1-bromo-4-fluoro-butane
State
State

1-Bromo-4-fluorobutane is a liquid at room temperature. Due to its relatively low boiling point, it can evaporate quickly at elevated temperatures.

Melting point (Celsius)
-97.60
Melting point (Kelvin)
175.60
Boiling point (Celsius)
130.00
Boiling point (Kelvin)
403.00
General information
Molecular weight
155.01g/mol
Molar mass
155.0080g/mol
Density
1.3738g/cm3
Appearence

1-Bromo-4-fluorobutane is typically a colorless liquid that may have a faint yet sharp odor. It should be stored in a cool, dry place to prevent any decomposition or reaction with environmental moisture or air.

Comment on solubility

Solubility of 1-Bromo-4-fluoro-butane

1-Bromo-4-fluoro-butane (C4H8BrF) exhibits unique solubility characteristics owing to the presence of both a bromine and a fluorine atom in its structure. This compound’s solubility can be influenced by several factors:

  • Polarity: 1-Bromo-4-fluoro-butane is a polar molecule due to the electronegative halogen atoms. This polar nature typically enhances solubility in polar solvents.
  • Solvent Type: It is generally more soluble in solvents that possess similar polarity, such as alcohols and acetone, while exhibiting lower solubility in non-polar solvents such as hexane.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with rising temperature, allowing for greater interaction with solvent molecules.

While 1-bromo-4-fluoro-butane is not highly soluble in water – often resulting in limited aqueous applications – it serves as a valuable solvent and reactant in organic chemistry due to its reasonable solubility in organic solvents. Thus, it is essential to consider these properties when selecting solvents for reactions involving this compound.

Interesting facts

Interesting Facts about 1-bromo-4-fluoro-butane

1-bromo-4-fluoro-butane is a fascinating compound that serves as a notable example in the field of organic chemistry, particularly in the study of halogenated hydrocarbons. Here are some compelling aspects of this compound:

  • Functional Groups: This compound contains both bromine and fluorine atoms, which contribute to its reactivity. These halogen substituents can significantly alter the physical and chemical properties of the base butane structure.
  • Applications in Synthesis: 1-bromo-4-fluoro-butane can be used as an essential building block in organic synthesis. Its halogen functionalities make it an excellent precursor for various chemical reactions, such as nucleophilic substitutions or eliminations.
  • Role in Medicinal Chemistry: Halogenated compounds often find application in pharmaceutical research. The presence of bromine and fluorine can enhance the biological activity and receptor binding properties of certain drug candidates.
  • Environmental Impact: The environmental implications of halogenated compounds are of considerable concern. As scientists increasingly focus on greener chemistry, understanding the degradation and toxicity of compounds like 1-bromo-4-fluoro-butane has become crucial.
  • Chirality Potential: Depending on the stereochemistry of the substituents, 1-bromo-4-fluoro-butane can yield chiral centers, leading to the formation of enantiomers. This property is pivotal in fields like asymmetric synthesis and chiral resolution.

In conclusion, 1-bromo-4-fluoro-butane not only aids in understanding basic organic chemistry principles but also has practical implications in various chemical industries. Its unique structure and properties make it a compound worthy of further exploration and study in both academic and industrial settings.

Synonyms
1-Bromo-4-fluorobutane
462-72-6
4-Fluorobutyl bromide
BUTANE, 1-BROMO-4-FLUORO-
1-bromo-4-fluoro-butane
BRN 1731414
fluorobutyl bromide
MFCD00209551
4-01-00-00263 (Beilstein Handbook Reference)
SCHEMBL281735
1-Bromo-4-fluorobutane, 98%
DTXSID70196767
AKOS006223450
CS-W018025
DB-019081
B5331
4-Fluorobutyl bromide, 4-Bromobutyl fluoride
1-bromo-4-fluoro-butan;4-Fluoro-1-bromobutane
A24612
D87758
EN300-206961
626-488-0