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4-Bromoanisole

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Identification
Molecular formula
C7H7BrO
CAS number
104-92-7
IUPAC name
1-bromo-4-methoxy-benzene
State
State

At room temperature, 4-Bromoanisole is typically in a liquid state, although it can crystallize just above room temperature. It is denser than water and has low solubility in it; however, it is soluble in organic solvents.

Melting point (Celsius)
9.00
Melting point (Kelvin)
282.15
Boiling point (Celsius)
219.50
Boiling point (Kelvin)
492.65
General information
Molecular weight
187.04g/mol
Molar mass
187.0480g/mol
Density
1.4880g/cm3
Appearence

4-Bromoanisole is a colorless to pale yellow liquid. It may also appear as crystals at lower temperatures. It has a distinct aromatic odor characteristic of methoxy-bromobenzenes.

Comment on solubility

Solubility of 1-bromo-4-methoxy-benzene

1-bromo-4-methoxy-benzene, also known as p-bromoanisole, exhibits interesting solubility characteristics due to its molecular structure. This compound is predominantly a nonpolar aromatic compound because of its benzene ring, which influences its interactions with solvents.

When considering its solubility, here's what you should note:

  • Polar vs. Nonpolar Solvents: 1-bromo-4-methoxy-benzene is more soluble in nonpolar solvents such as hexane and toluene due to similar intermolecular forces. Conversely, it has limited solubility in polar solvents like water.
  • Temperature Effects: The solubility can increase with temperature. As temperature rises, the kinetic energy of the molecules increases, often enhancing solubility in a given solvent.
  • Functional Groups: The presence of a methoxy group (—OCH3) can provide some polar character; however, its overall effect is not strong enough to significantly increase solubility in water.

In summary, 1-bromo-4-methoxy-benzene tends to be soluble in nonpolar environments, making it an excellent candidate for organic reactions where nonpolar solvents are utilized. As with many organic compounds, always consider the nature of the solvent to predict solubility effectively.

Interesting facts

Interesting Facts About 1-Bromo-4-methoxy-benzene

1-Bromo-4-methoxy-benzene, commonly referred to as para-bromo-anisole, is an intriguing compound in the field of organic chemistry. This compound belongs to the class of aryl halides and has significant applications in various chemical processes. Here are some fascinating points about this compound:

  • Versatile Building Block: 1-Bromo-4-methoxy-benzene is often utilized as a precursor in the synthesis of various chemical compounds, including pharmaceuticals and agrochemicals.
  • Halogen Chemistry: The bromine atom attached to the benzene ring enhances the electrophilicity of the aromatic system, making it significantly reactive in nucleophilic substitution reactions.
  • Common Reactions: This compound can undergo a variety of reactions such as Grignard reactions, cross-coupling reactions, and electrophilic aromatic substitutions, showcasing the versatility of brominated aromatic compounds.
  • Pharmaceutical Relevance: Compounds like 1-bromo-4-methoxy-benzene can serve as important intermediates in the development of various drugs, highlighting the intersection of organic chemistry with medicinal chemistry.
  • Environmental Considerations: The study of halogenated compounds is significant not only for their utility but also for understanding their environmental impact, as halogens can influence the degradation pathways of organic pollutants.

In summary, 1-bromo-4-methoxy-benzene is more than just a simple molecular assembly; it plays a pivotal role in advancing chemical knowledge and applications. Its reactions and derivatives continue to be of interest in the realms of synthetic and material chemistry. As the field evolves, compounds like this one serve as crucial links connecting foundational chemistry to innovative applications.

Synonyms
4-BROMOANISOLE
104-92-7
1-Bromo-4-methoxybenzene
p-Bromoanisole
4-Methoxybromobenzene
Benzene, 1-bromo-4-methoxy-
Anisyl bromide
p-Anisyl bromide
p-Bromanisole
4-Methoxyphenyl bromide
Anisole, p-bromo-
p-Methoxybromobenzene
p-Methoxyphenyl bromide
4-Methoxy-1-bromobenzene
p-Bromophenyl methyl ether
4-Bromoanisol
para-bromoanisole
4-anisyl bromide
4-bromo-1-methoxybenzene
p-Bromomethoxybenzene
4-bromomethoxybenzene
NSC 8042
p-bromoanisol
1-bromo-4-methoxy-benzene
EINECS 203-252-1
UNII-U430F901J9
4-Bromoanisole-d3
AI3-01295
NSC-8042
1-methoxy-4-bromobenzene
MFCD00000097
4-bromophenyl methyl ether
U430F901J9
DTXSID2059308
CHEBI:47257
EC 203-252-1
BROMOPHENOL P-FORM METHYL ETHER [MI]
4-bromo anisole
4-?Bromoanisole(p-?Methoxyphenyl Bromide)
pBromanisole
pBromoanisole
4bromoanisole
monobromoanisole
p-bromanisol
pAnisyl bromide
p-bromo anisole
p-bromo-anisole
Anisole, pbromo
parabromo-anisole
4-bromo-anisole
pMethoxybromobenzene
4Methoxybromobenzene
1Bromo4methoxybenzene
4Methoxy1bromobenzene
pMethoxyphenyl bromide
4Methoxyphenyl bromide
4-methoxy-bromobenzene
Benzene, 1bromo4methoxy
pBromophenyl methyl ether
1-bromo-4-methoxy benzene
SCHEMBL9301
1-bromanyl-4-methoxy-benzene
4-Bromoanisole, >=99.0%
DTXCID1032856
NSC8042
AEA83559
BCP24447
STR04213
BR1023
STL453648
AKOS000119001
BROMOPHENOL P-FORM METHYL ETHER
FB64620
PS-5119
1-Bromo-4-methoxybenzene; p-Bromoanisole
B0547
NS00006081
EN300-16110
A801100
Q4973725
F0001-0093
203-252-1