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1-Chloro-2-nitro-4-(trifluoromethyl)benzene

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Identification
Molecular formula
C7H3ClF3NO2
CAS number
607-34-1
IUPAC name
1-chloro-2-nitro-4-(trifluoromethyl)benzene
State
State

At room temperature, 1-chloro-2-nitro-4-(trifluoromethyl)benzene is generally a solid. It is stable under standard conditions, but like many nitro compounds, it should be handled with care.

Melting point (Celsius)
40.00
Melting point (Kelvin)
313.15
Boiling point (Celsius)
228.00
Boiling point (Kelvin)
501.15
General information
Molecular weight
225.56g/mol
Molar mass
225.5560g/mol
Density
1.5800g/cm3
Appearence

1-Chloro-2-nitro-4-(trifluoromethyl)benzene typically appears as an off-white to pale yellow crystalline solid. It may appear denser or more granular depending on its form, yet retains its typical coloration.

Comment on solubility

Solubility of 1-Chloro-2-nitro-4-(trifluoromethyl)benzene

1-Chloro-2-nitro-4-(trifluoromethyl)benzene, also known as CF3C6H3ClN2O2, exhibits selective solubility characteristics that are important to understand in various applications. Here are some key points regarding its solubility:

  • Water solubility: This compound is generally considered insoluble in water due to its large hydrophobic trifluoromethyl (-CF3) group, which reduces its ability to interact with water molecules.
  • Organic solvents: It demonstrates good solubility in a variety of apolar organic solvents such as benzene, toluene, and dichloromethane. This property makes it suitable for certain organic synthesis procedures.
  • Temperature dependence: Solubility may change with temperature, where higher temperatures often increase solubility in organic solvents. Remember that this is a general trend and specific experiments should be considered for accurate data.

To summarize, the solubility profile of 1-chloro-2-nitro-4-(trifluoromethyl)benzene is heavily influenced by its molecular structure, particularly the presence of the trifluoromethyl group, making it largely insoluble in polar solvents like water and more favorable towards apolar organic solvents. This knowledge is essential for effective handling and application in chemical processes.

Interesting facts

Interesting Facts about 1-Chloro-2-nitro-4-(trifluoromethyl)benzene

1-Chloro-2-nitro-4-(trifluoromethyl)benzene is a fascinating compound that combines various functional groups into a single aromatic structure. Here are some intriguing aspects of this compound:

  • Chemical Activity: The presence of both a nitro group and a chloro atom on the benzene ring significantly influences its reactivity. This makes it an important intermediate in organic synthesis, particularly in the manufacture of pharmaceuticals and agrochemicals.
  • Fluorinated Properties: The trifluoromethyl group (-CF3) is known for its unique electronic and steric properties. It enhances the lipophilicity of the compound, which can lead to better biological activity and stability in various applications.
  • Environmental Considerations: Compounds containing fluorine are often scrutinized due to their persistence in the environment. Understanding their behavior and degradation pathways is crucial for assessing their ecological impact.
  • Applications: This compound is valuable in the development of agrochemicals and pharmaceuticals. Due to its structural characteristics, it can act as a building block for more complex molecules.
  • Research Material: As a subject of study, researchers explore the compound's properties and potential applications in fields ranging from material science to medicinal chemistry. Its efficacy in drug design is a noteworthy area of research.

In summary, 1-Chloro-2-nitro-4-(trifluoromethyl)benzene is more than just an aromatic compound; it embodies a blend of chemistry that is not only relevant in the lab but also has significant implications in real-world applications. As researchers continue to explore its potential, we may uncover even more exciting uses and properties of this compound.

Synonyms
4-CHLORO-3-NITROBENZOTRIFLUORIDE
121-17-5
1-Chloro-2-nitro-4-(trifluoromethyl)benzene
3-Nitro-4-chlorobenzotrifluoride
2-Nitro-4-trifluoromethylchlorobenzene
Benzene, 1-chloro-2-nitro-4-(trifluoromethyl)-
2-Chloro-5-(trifluoromethyl)nitrobenzene
3-Nitro-4-chlorotrifluoromethylbenzene
4-Chloro-3-nitro-a,a,a-trifluorotoluene
4-Chloro-3-nitrobenzylidyne fluoride
NSC 8760
4-Chloro-3-nitro-alpha,alpha,alpha-trifluorotoluene
Benzotrifluoride, 4-chloro-3-nitro-
4-Chloro-3-nitro-1-(trifluoromethyl)benzene
2-Chloro-5-trifluoromethylnitrobenzene
CCRIS 2817
HSDB 4257
EINECS 204-451-6
UN2307
BRN 0523986
DTXSID2024799
3-Nitro-4-chloro-alpha,alpha,alpha-trifluorotoluene
4-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene
AI3-26184
UNII-82344306TN
NSC-8760
MFCD00007084
3-Nitro-4-(chloro)trifluoromethylbenzene
DTXCID104799
EC 204-451-6
4-05-00-00857 (Beilstein Handbook Reference)
4-chloro-3-nitrotrifluoromethylbenzene
Toluene, 4-chloro-3-nitro-alpha,alpha,alpha-trifluoro-
UN 2307
2-Nitro-4-(trifluoromethyl)chlorobenzene
4-Chloro-3-nitro-.alpha.,.alpha.,.alpha.-trifluorotoluene
CMNT
Toluene, 4-chloro-.alpha.,.alpha.,.alpha.-trifluoro-3-nitro-
82344306TN
4-TRIFLUOROMETHYL-2-NITROCHLOROBENZENE
4-CHLORO-3-NITROBENZOTRIFLUORIDE [HSDB]
3-Nitro-4-chloro-.alpha.,.alpha.,.alpha.-trifluorotoluene
4-Chloro-.alpha.,.alpha.,.alpha.-trifluoro-3-nitrotoluene
Toluene, 4-chloro-3-nitro-.alpha.,.alpha.,.alpha.-trifluoro-
CAS-121-17-5
Toluene, 4-chloro-alpha,alpha,alpha-trifluoro-3-nitro-
4-chloro-1-trifluoromethyl-3-nitro-benzene
3Nitro4chlorobenzotrifluoride
MLS002454377
SCHEMBL140068
Benzotrifluoride, 4chloro3nitro
CHEMBL1723690
4Chloro3nitrobenzylidyne fluoride
NITROCHLOROBENZOTRIFLUORIDE
NSC8760
2Nitro4trifluoromethylchlorobenzene
3Nitro4chlorotrifluoromethylbenzene
4-chloro-3-nitro-benzotrifluoride
4-chloro-3-nitrobenzo-trifluoride
3-Nitro-4-chloro-benzotrifluoride
HMS3039H03
4-chloro- 3-nitro-benzotrifluoride
Tox21_201833
Tox21_303339
2Chloro5(trifluoromethyl)nitrobenzene
STL264265
4Chloro3nitro1(trifluoromethyl)benzene
AKOS000120171
CS-W001073
FC05661
2-chloro-5-trifluoromethyl-nitrobenzene
4-Chloro-3-nitrobenzotrifluoride, 97%
(3-Nitro-4-chlorophenyl)trifluoromethane
Benzene, 1chloro2nitro4(trifluoromethyl)
NCGC00091167-01
NCGC00091167-02
NCGC00257234-01
NCGC00259382-01
AC-10902
PD013788
PS-10522
SMR001371997
1-chloro-2-nitro-4-trifluoromethylbenzene
1-Chloro-4-trifluoromethyl-2-nitrobenzene
2-chloro-1-nitro-5-trifluoromethylbenzene
2-nitro-4-trifluoromethyl-1-chlorobenzene
4-chloro-3-nitro-1-trifluoromethylbenzene
1-Chloro-2-nitro-4-trifluoromethyl-benzene
4-chloro-3-nitro-1-trifluoromethyl-benzene
A2547
NS00006779
PARA-CHLORO-META-NITROTRIFLUOROTOLUENE
Toluene,.alpha.,.alpha.-trifluoro-3-nitro-
3Nitro4chloroalpha,alpha,alphatrifluorotoluene
4Chloro3nitroalpha,alpha,alphatrifluorotoluene
4Chloroalpha,alpha,alphatrifluoro3nitrotoluene
EN300-17932
1-Chloro-2-nitro-4-(trifluoromethyl)benzene #
E78890
6-CHLORO-3-(TRIFLUOROMETHYL)NITROBENZENE
Toluene, 4chloroalpha,alpha,alphatrifluoro3nitro
2-CHLORO-5-(TRIFLUOROMETHYL)-1-NITROBENZENE
2-NITRO-4-(TRIFLUOROMETHYL)-1-CHLOROBENZENE
3-NITRO-4-CHLORO-1-(TRIFLUOROMETHYL)BENZENE
4-Chloro-.alpha.,.alpha.-trifluoro-3-nitrotoluene
Q27269296
Z57117625
3-Nitro-4-chlorobenzotrifluoride [UN2307] [Poison]
F0001-0340
4-chloro-3-nitro-alpha,alpha,alpha-trifluorotoluene;3-Nitro-4-chlorobenzotrifluoride; 4-chloro-a,a,a-trifluoro-3-nitrotoluene