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1-Chloro-2-(trifluoromethyl)benzene

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Identification
Molecular formula
C7H4ClF3
CAS number
1333-84-8
IUPAC name
1-chloro-2-(trifluoromethyl)benzene
State
State
At room temperature, 1-chloro-2-(trifluoromethyl)benzene is in a liquid state. It is often utilized in organic synthesis and may have a characteristic aromatic odor.
Melting point (Celsius)
-14.00
Melting point (Kelvin)
259.15
Boiling point (Celsius)
144.70
Boiling point (Kelvin)
417.85
General information
Molecular weight
178.56g/mol
Molar mass
178.5580g/mol
Density
1.3679g/cm3
Appearence
1-Chloro-2-(trifluoromethyl)benzene is a colorless liquid that appears transparent. It is typically clear with no distinguishing color when pure, making it rather inconspicuous when handled in laboratory conditions.
Comment on solubility

Solubility of 1-chloro-2-(trifluoromethyl)benzene

1-chloro-2-(trifluoromethyl)benzene, also known as o-chlorobenzotrifluoride, exhibits unique solubility characteristics due to its molecular structure. Here are some key points regarding its solubility:

  • Polarity: The presence of both the chloro and trifluoromethyl groups increases the polarity of the compound, making it less soluble in nonpolar solvents.
  • Solvent Compatibility: Generally, 1-chloro-2-(trifluoromethyl)benzene is more soluble in polar organic solvents compared to nonpolar ones. Solvents like acetone and ethanol can facilitate better solvation.
  • Water Solubility: This compound is insoluble in water due to its hydrophobic aromatic structure and high molecular weight, which hinders its interaction with water molecules.
  • Temperature Dependency: Its solubility can be influenced by temperature; increasing the temperature typically improves solubility in organic solvents.

In conclusion, while 1-chloro-2-(trifluoromethyl)benzene shows limited solubility in water, its compatibility with various organic solvents allows for flexibility in usage across different chemical processes. Understanding its solubility behavior is essential for practical applications in synthesis and formulation.

Interesting facts

Interesting Facts About 1-chloro-2-(trifluoromethyl)benzene

1-chloro-2-(trifluoromethyl)benzene, often referred to in the industry as a *fluorinated aromatic compound*, is a fascinating molecule that carries a number of significant characteristics and applications:

  • Fluorination Effect: The presence of the trifluoromethyl group (–CF3) significantly impacts the properties of the molecule, enhancing its stability and reactivity. This modification can lead to unique interactions in chemical reactions, making it a valuable compound in synthetic chemistry.
  • Industrial Applications: This specific compound is widely utilized in the production of agrochemicals and pharmaceuticals. Its ability to act as a building block for more complex molecules is of particular interest to chemists seeking to innovate in drug design.
  • Environmental Considerations: Due to the *high stability* of fluorinated compounds, 1-chloro-2-(trifluoromethyl)benzene is also studied in environmental science, especially when considering its persistence and potential impact on ecosystems.
  • Structure Activity Relationship (SAR): Researchers explore the structure-activity relationships of compounds like this one, establishing how minor changes, such as the addition of a chlorine atom or a trifluoromethyl group, can significantly alter biological activity.
  • Innovation in Material Science: Beyond its role in organic synthesis, this compound is explored for its potential contributions to material science, including the development of specialized coatings and polymers that benefit from low surface energy and unique thermal properties.

In summary, 1-chloro-2-(trifluoromethyl)benzene exemplifies the versatility and importance of fluorinated compounds in advancing technology and science. Its blend of *chemical stability* and *reactivity* opens up numerous avenues for research and application.

Synonyms
2-Chlorobenzotrifluoride
88-16-4
1-Chloro-2-(trifluoromethyl)benzene
o-Chlorobenzotrifluoride
Chlorobenzotrifluoride
2-Chloro(trifluoromethyl)benzene
o-(Trifluoromethyl)chlorobenzene
Benzene, 1-chloro-2-(trifluoromethyl)-
2-Chloro-alpha,alpha,alpha-trifluorotoluene
o-(Trifluoromethyl)phenyl chloride
52181-51-8
2-Chloro-benzotrifluoride
Benzene, chloro(trifluoromethyl)-
Chlorotrifluorotoluene
o-Chloro-alpha,alpha,alpha-trifluorotoluene
(Trifluoromethyl)chlorobenzene
CHLORO(TRIFLUOROMETHYL)BENZENE
NSC 10307
CCRIS 2809
2-(TRIFLUOROMETHYL)CHLOROBENZENE
EINECS 201-805-1
0V2SO8M97N
DTXSID9024774
NSC-10307
DTXCID504774
2-trifluoromethylphenyl chloride
Toluene, o-chloro-alpha,alpha,alpha-trifluoro-
CHLOROBENZOTRIFLUORIDE, O-
THIOPHEN-2-YL METHYL KETONE
2-Chloro-.alpha.,.alpha.,.alpha.-trifluorotoluene
o-Chloro-.alpha.,.alpha.,.alpha.-trifluorotoluene
MFCD00000561
1-chloro-2-(trifluoromethyl)-benzene
Toluene, o-chloro-.alpha.,.alpha.,.alpha.-trifluoro-
O-TRIFLUOROMETHYLPHENYL CHLORIDE
o-chlorbenzotrifluorid
ortho-chlorobenzotrifluoride
UNII-0V2SO8M97N
2-chlorotrifluoromethylbenzene
SCHEMBL117692
2-trifluoromethyl-chlorobenzene
.ALPHA.-ACETYLTHIOPHENE
2-Chlorobenzotrifluoride, 99%
CHEMBL1301432
DTXSID701064337
NSC10307
1-(trifluoromethyl)-2-chlorobenzene
Tox21_200751
AKOS000120010
CAS-88-16-4
NCGC00091794-01
NCGC00091794-02
NCGC00258305-01
AC-10784
PS-11777
o-Chloro-.alpha.,.alpha.-trifluorotoluene
DB-301339
NS00001799
EN300-20289
E78996
Q27237282
Toluene, o-chloro-alpha,alpha,alpha-trifluoro-(8CI)
2-Chloro-alpha,alpha,alpha-trifluorotoluene; 1-Chloro-2-(trifluoromethyl)benzene; 2-Chloro(trifluoromethyl)benzene
201-805-1