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Metronidazole Chlorohydrin

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Identification
Molecular formula
C7H10ClN3O3
CAS number
55112-37-7
IUPAC name
1-chloro-3-(2-methyl-5-nitro-imidazol-1-yl)propan-2-ol
State
State

It is typically a solid at room temperature.

Melting point (Celsius)
160.00
Melting point (Kelvin)
433.00
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
236.64g/mol
Molar mass
236.6440g/mol
Density
1.4500g/cm3
Appearence

The compound typically appears as a crystalline solid and may have a pale yellow or white color. It is crystalline and may sometimes appear semi-transparent.

Comment on solubility

Solubility of 1-Chloro-3-(2-methyl-5-nitro-imidazol-1-yl)propan-2-ol

The solubility of 1-chloro-3-(2-methyl-5-nitro-imidazol-1-yl)propan-2-ol is influenced by several structural factors, making it an interesting compound to analyze. Here are some key points to consider:

  • Polarity: The presence of a nitro group (-NO2) and a hydroxyl group (-OH) suggests that the compound may exhibit a degree of polarity, which can enhance its solubility in polar solvents, such as water.
  • Hydrophobic Character: The chloro and imidazol components might introduce some hydrophobic character, potentially reducing solubility in highly polar environments.
  • Solvent Compatibility: This compound is likely to be more soluble in organic solvents, like ethanol or methanol, compared to water due to the mixed functionalities.
  • Temperature Dependence: Like many organic compounds, solubility can vary with temperature increases, often leading to improved solubility at elevated temperatures.

In summary, the solubility profile of 1-chloro-3-(2-methyl-5-nitro-imidazol-1-yl)propan-2-ol is shaped by its structural characteristics, offering different behaviors in varying solvent environments. As always, experimental determination is essential to accurately assess solubility under specific conditions.

Interesting facts

Interesting Facts about 1-chloro-3-(2-methyl-5-nitro-imidazol-1-yl)propan-2-ol

This compound, often abbreviated for convenience, is an intriguing example of a halogenated alcohol with significant applications in medicinal and chemical research. Here are some fascinating aspects to consider:

  • Medical Relevance: 1-chloro-3-(2-methyl-5-nitro-imidazol-1-yl)propan-2-ol has been studied for its potential antibacterial and antifungal properties, making it a candidate for developing new therapeutic agents.
  • Structural Diversity: The presence of the imidazole ring enhances the compound's capability to interact with biological systems. This can influence its reactivity, pharmacokinetics, and overall biological efficacy.
  • Eco-Conscious Design: As scientists push for greener chemistry, this compound's synthesis can be optimized to minimize waste and reduce environmental impact, showcasing the principles of *sustainable chemistry*.
  • Research Tool: Compounds of this type serve as valuable tools in biochemical research. They can be employed to understand enzyme mechanisms, drug interactions, or pathways in cellular processes.
  • Potential for Modification: The presence of the chloro group in the structure indicates possibilities for further chemical modifications, allowing for the exploration of various derivatives that could have different biological effects.

A noteworthy quote reflects the spirit of innovation in chemistry: "In every experiment, there lies an opportunity for discovery."
As research continues, compounds like this may lead us to breakthroughs not only in understanding fundamental chemistry but also in combating challenging diseases.

Synonyms
Ornidazole
16773-42-5
Tiberal
Ro 7-0207
Ornidazol
Ornidazolum
1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
1-(3-Chloro-2-hydroxypropyl)-2-methyl-5-nitroimidazole
Ro-70207
1-(2-Hydroxy-3-chloropropyl)-2-methyl-5-nitroimidazole
1H-Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
CHEBI:75176
NSC-95075
62XCK0G93T
alpha-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol
DTXSID4045420
alpha-(Chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol
RO-7-0207
DTXCID2025420
Ro7-0207
ornidazolo
Ro70207
Ro 70207
Ro7 0207
Ro 7 0207
G01AF06
J01XD03
P01AB03
240-826-0
Madelen
MFCD00057960
NSC 95075
1-chloro-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol
alpha-(Chloromethyl)-2-methyl-5-nitroimidazole-1-ethanol
1H-Imidazole-1-ethanol, .alpha.-(chloromethyl)-2-methyl-5-nitro-
MLS000028628
NSC95075
1-chloro-3-(2-methyl-5-nitro-imidazol-1-yl)propan-2-ol
.alpha.-(Chloromethyl)-2-methyl-5-nitroimidazole-1-ethanol
SMR000058726
Imidazole-1-ethanol, .alpha.-(chloromethyl)-2-methyl-5-nitro-
1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)-2-propanol
Ornidal
Ornidazole [USAN:INN]
Ornidazol [INN-Spanish]
Ornidazolum [INN-Latin]
(R)-Ornidazole
CCRIS 9030
NSC-759295
SR-01000000256
EINECS 240-826-0
3-chloro-1-(2-methyl-5-nitroimidazolyl)propan-2-ol
BRN 0614299
UNII-62XCK0G93T
NCGC00016723-01
Prestwick_584
CAS-16773-42-5
Ornidazole (Standard)
ORNIDAZOLE [MI]
ORNIDAZOLE [INN]
alpha-(Chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol [German]
Opera_ID_1555
Ornidazole (USAN/INN)
Prestwick0_000164
Prestwick1_000164
Prestwick2_000164
Prestwick3_000164
(.+/-.)-Ornidazole
ORNIDAZOLE [USAN]
ORNIDAZOLE [MART.]
NCIOpen2_006374
ORNIDAZOLE [WHO-DD]
SCHEMBL43039
BSPBio_000027
5-23-05-00072 (Beilstein Handbook Reference)
MLS001424188
SPBio_001948
Ornidazole, analytical standard
BPBio1_000031
orb1308205
CHEMBL1449676
HY-B0508R
MSK5591
HMS1568B09
HMS2051D22
HMS2093J22
HMS2095B09
HMS2234L22
HMS3373M17
HMS3393D22
HMS3652C03
HMS3712B09
HMS5081O16
Imidazole-1-ethanol, alpha-(chloromethyl)-2-methyl-5-nitro-
Pharmakon1600-01505981
BCP12975
BCP13382
BCP34382
HY-B0508
Tox21_110582
BBL005302
BDBM50247904
NSC759295
s3121
SBB006918
STK629340
AKOS005111039
AKOS015894928
Tox21_110582_1
AB02333
AC-2025
CCG-101064
CCG-213587
DB13026
FO26585
NC00314
NCGC00018275-02
NCGC00018275-05
AS-12121
SBI-0206881.P001
AB00513814
NS00004561
O0417
ST45053251
SW196758-4
D05274
AB00383044_14
AB00383044_15
EN300-6731079
Ornidazole Levo-;Ornidazole Impurity 7;Levornidazole
Q2358146
SR-01000000256-3
SR-01000000256-4
BRD-A42759514-001-03-1
BRD-A42759514-001-09-8
BRD-A42759514-001-19-7
BRD-A42759514-001-20-5
BRD-A42759514-001-21-3
1-chloro-3-(2-methyl-5-nitro-1-imidazolyl)-2-propanol
F2173-0936
Z1269240018
.alpha.-(Chlormethyl)-2-methyl-5-nitro-imidazol-1-aethanol
1-chloro-3-(2-methyl-5-nitro-1N-imidazol-1-yl)propan-2-ol
1H-Imidazole-1-ethanol, |A-(chloromethyl)-2-methyl-5-nitro-
.alpha.-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol
1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)-2-propanol #
Ornidazole,1(3-chloro-2-hydroxypropyl)-2-methyl-5-nitro imidazole
Ornidazole, (R)-;(R)-1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
a-(Chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol;1-(3-chloro-2-hydroxypropyl)-2-methyl-5-nitro imidazole