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4-Chlorothioanisole

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Identification
Molecular formula
C7H7ClS
CAS number
873-32-5
IUPAC name
1-chloro-4-methylsulfanyl-benzene
State
State

4-Chlorothioanisole is typically a liquid at room temperature.

Melting point (Celsius)
-13.00
Melting point (Kelvin)
260.15
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.15
General information
Molecular weight
158.65g/mol
Molar mass
158.6520g/mol
Density
1.1800g/cm3
Appearence

4-Chlorothioanisole is a colorless to pale yellow liquid with a distinctive aromatic odor. It is often used in organic synthesis and may appear slightly viscous.

Comment on solubility

Solubility of 1-chloro-4-methylsulfanyl-benzene

1-chloro-4-methylsulfanyl-benzene, commonly known as p-chlorothiotoluene, exhibits interesting solubility characteristics that are influenced by its structure. Here are some key aspects of its solubility:

  • Polar vs. Non-Polar: The presence of the chlorine atom and the methylthio group contributes to its overall polarity, making it *less soluble in water*. Generally, compounds with significant non-polar characteristics are not very soluble in polar solvents like water.
  • Organic Solvents: This compound tends to be soluble in organic solvents such as *ethanol, acetone*, and *chloroform*. This solubility in organic media is typical for aromatic compounds.
  • Influence of Substituents: The methylthio group enhances the solubility in organic solvents while the chlorine atom may present a steric hindrance, affecting the intermolecular forces and solvation dynamics.

To summarize, 1-chloro-4-methylsulfanyl-benzene is characterized by:

  1. A low solubility in water due to its non-polar aromatic structure.
  2. A good solubility in various organic solvents, promoting its use in organic synthesis and various chemical applications.
  3. Interactions driven by its substituents that alter solvation properties.

In conclusion, the solubility profile of this compound is particularly interesting and serves as a reminder of the complex behaviors exhibited by aromatic chemical structures.

Interesting facts

Interesting Facts about 1-Chloro-4-methylsulfanyl-benzene

1-Chloro-4-methylsulfanyl-benzene, also known as p-chloro-thio-toluene, is an intriguing compound that belongs to the class of aromatic compounds. This compound presents notable features that make it of interest in various fields of chemistry.

Chemical Properties and Reactions

  • Electrophilic Aromatic Substitution: The presence of both the chlorine atom and the methylthio group on the benzene ring significantly influences the reactivity of the compound. The chlorine atom is a deactivating group, while the methylthio group can direct new substituents to the ortho and para positions, making positional isomers interesting to explore.
  • Solubility Traits: Generally, in organic solvents, the compound exhibits varying degrees of solubility. Its solubility characteristics are particularly essential for applications in organic synthesis and pharmaceuticals.

Applications

  • Pharmaceuticals: This compound may be involved in the synthesis of various pharmaceutical agents due to its unique functional groups.
  • Synthesis Intermediate: 1-Chloro-4-methylsulfanyl-benzene can act as a building block for more complex molecules in organic synthesis.

Fun Facts

  • Versatility: The combination of chlorine and thiol groups makes this compound a versatile precursor in organic chemistry, allowing chemists to design a myriad of derivatives.
  • Chlorinated Compounds: It stands out as an example of chlorinated organic compounds, which are often researched for their environmental impact and potential contributions to organic synthesis.

As a compound in the aromatic family, 1-chloro-4-methylsulfanyl-benzene not only showcases remarkable chemical behaviors but also opens doors to exciting reactions and applications in both industrial and academic settings. Its study can lead to further innovations in material science and pharmacology, making it a noteworthy candidate for research.

Synonyms
123-09-1
4-Chlorophenyl methyl sulfide
1-CHLORO-4-(METHYLTHIO)BENZENE
p-Chlorothioanisole
Methyl 4-chlorophenyl sulfide
Methyl p-chlorophenyl sulfide
Sulfide, p-chlorophenyl methyl
031E43FWKK
DTXSID8023973
NSC-72090
DTXCID403973
CPMS
RefChem:522033
para-chlorophenyl methyl sulfide
204-600-5
4-Chlorothioanisole
Benzene, 1-chloro-4-(methylthio)-
P-CHLOROPHENYL METHYL SULFIDE
1-Chloro-4-(methylsulfanyl)benzene
p-Chlophenyl methyl sulfide
1-chloro-4-methylsulfanylbenzene
NSC 72090
MFCD00013643
(4-chlorophenyl)(methyl)sulfane
CAS-123-09-1
CCRIS 6731
EINECS 204-600-5
BRN 2041509
UNII-031E43FWKK
1-chloro-4-methylsulfanyl-benzene
4-Chlorothioanisole, 98%
SCHEMBL96393
1-methylthio-4-chlorobenzene
4-chloro-1-methylthiobenzene
Methyl-p-chlorophenyl sulfide
SCHEMBL316469
SCHEMBL358182
SCHEMBL1045140
SCHEMBL2556959
CHEMBL1898714
KIQQUVJOLVCZKG-UHFFFAOYSA-
(4-chloro-phenyl)-methyl-sulfide
P-(METHYLTHIO)CHLOROBENZENE
NSC72090
STR05544
Tox21_202358
Tox21_303311
4-METHYLTHIO-1-CHLOROBENZENE
AKOS008907883
PS-4889
NCGC00164205-01
NCGC00164205-02
NCGC00256947-01
NCGC00259907-01
DB-041707
CS-0204470
NS00024006
ST50410554
D89361
F002972
Q27231568
InChI=1/C7H7ClS/c1-9-7-4-2-6(8)3-5-7/h2-5H,1H3