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Dimethylaminopropyl chloride

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Identification
Molecular formula
C5H12ClN
CAS number
5407-04-5
IUPAC name
1-chloro-N,N-dimethyl-propan-2-amine
State
State

At room temperature, the compound is in a liquid state.

Melting point (Celsius)
-52.00
Melting point (Kelvin)
221.15
Boiling point (Celsius)
103.00
Boiling point (Kelvin)
376.15
General information
Molecular weight
107.59g/mol
Molar mass
107.5910g/mol
Density
0.8794g/cm3
Appearence

This compound is usually a colorless to pale yellow liquid.

Comment on solubility

Solubility of 1-chloro-N,N-dimethyl-propan-2-amine

1-chloro-N,N-dimethyl-propan-2-amine, with the formula C5H12ClN, presents interesting solubility characteristics that are influenced by its molecular structure. This compound's solubility can be summarized as follows:

  • Polarity: Due to the presence of both a chlorine atom and an amine functional group, the molecule exhibits polar characteristics, which can enhance its solubility in polar solvents.
  • Solvent Compatibility: This compound is generally soluble in water and other polar solvents such as alcohols. It may show limited solubility in non-polar solvents, reflecting the significance of intermolecular interactions.
  • Hydrogen Bonding: The amine group can engage in hydrogen bonding with water molecules, facilitating an increase in solubility in aqueous environments.

However, it's important to note that solubility can be affected by various factors, including:

  1. Temperature: Increased temperature often leads to increased solubility for ionic and polar compounds.
  2. pH Levels: The solubility of amines can change significantly with pH, as they tend to become protonated in acidic conditions, which can enhance solubility.
  3. Presence of Salts: The addition of salts in a solution can also influence solubility through the 'salting in' or 'salting out' effects.

In conclusion, the solubility of 1-chloro-N,N-dimethyl-propan-2-amine is predominantly favorable in polar solvents, primarily due to its polar nature and ability to form hydrogen bonds. Understanding these solubility parameters is essential for applications in synthesis and formulation processes.

Interesting facts

Interesting Facts About 1-chloro-N,N-dimethyl-propan-2-amine

1-chloro-N,N-dimethyl-propan-2-amine, also known as a type of alkyl amine, possesses unique characteristics that make it noteworthy in both industrial and research settings. Here are several intriguing aspects:

  • Versatile Applications: This compound is employed in various fields including pharmaceuticals, agrochemicals, and as a solvent. Due to its ability to function as an intermediate, it plays a crucial role in the synthesis of more complex molecules.
  • Reactivity: The presence of the chlorine atom makes 1-chloro-N,N-dimethyl-propan-2-amine a potent electrophile. This characteristic enables it to participate in nucleophilic substitution reactions, allowing chemists to design reactions that yield diverse products.
  • Biological Relevance: Compounds like this are of particular interest in medicinal chemistry, where they can mimic or modify biological activity. Understanding their interactions at the molecular level can lead to the development of new therapeutic agents.
  • Synthesis Insights: The synthesis pathway for 1-chloro-N,N-dimethyl-propan-2-amine often involves straightforward reactions, enabling students and chemists alike to explore and practice organic synthesis methods.
  • Safety and Handling: As with many amine compounds, proper handling is crucial. Understanding its properties helps in developing guidelines for safe use in laboratory and industrial settings.

In summary, 1-chloro-N,N-dimethyl-propan-2-amine serves as a fascinating compound for both academic study and practical applications. Its ability to participate in various reactions and its significance in the synthetic organic chemistry landscape position it as a valuable subject for scientists and students alike.

Synonyms
53309-35-6
1-CHLORO-N,N-DIMETHYL-2-PROPYLAMINE
DTXSID50274855
DTXCID40226308
1-chloro-N,N-dimethylpropan-2-amine
2-Propanamine, 1-chloro-N,N-dimethyl-
Promethazine lmpurity 31
1-Chlor-2-dimethylaminopropan
SCHEMBL2119491
2-(N,N-dimethylamino)propyl chloride
AKOS006311613
DA-20320