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2-Fluorobenzyl chloride

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Identification
Molecular formula
C7H6ClF
CAS number
446-48-0
IUPAC name
1-(chloromethyl)-2-fluoro-benzene
State
State

At room temperature, 2-Fluorobenzyl chloride exists as a liquid.

Melting point (Celsius)
-27.00
Melting point (Kelvin)
246.15
Boiling point (Celsius)
178.00
Boiling point (Kelvin)
451.15
General information
Molecular weight
142.56g/mol
Molar mass
142.5640g/mol
Density
1.1970g/cm3
Appearence

2-Fluorobenzyl chloride is typically a clear, colorless to yellow liquid. It might have a characteristic pungent odor, often associated with chlorinated organic compounds.

Comment on solubility

Solubility of 1-(chloromethyl)-2-fluoro-benzene

The solubility of 1-(chloromethyl)-2-fluoro-benzene, a compound characterized by its unique halogen substitutions, can be particularly interesting. Generally, the properties of such halogenated compounds are influenced by the presence of both the chlorine and fluorine atoms, which alter the polar nature of the molecule.

In assessing its solubility, we may consider several factors:

  • Polarity: The inclusion of halogens increases the molecule's overall polarity, yet it is still predominantly non-polar due to its aromatic structure.
  • Solvent Interaction: It tends to be more soluble in non-polar solvents, such as organic solvents, due to similar interactions with non-polar solutes.
  • Temperature Effects: Increasing temperature may enhance solubility in certain solvents as molecular movement increases.
  • Environmental Considerations: Its solubility behavior in water is low, making it less favorable for biodegradability and environmental dispersion.

In conclusion, while 1-(chloromethyl)-2-fluoro-benzene is relatively low in water solubility, it exhibits higher solubility in non-polar organic solvents. This leads to its practical applications and considerations in various chemical processes. As the old saying goes, "like dissolves like," highlighting the importance of choosing the appropriate solvent for its use.

Interesting facts

Interesting Facts about 1-(Chloromethyl)-2-fluoro-benzene

1-(Chloromethyl)-2-fluoro-benzene is a fascinating compound within the realm of organic chemistry, particularly due to its unique structure and reactivity. Here are some key points of interest:

  • Chemical Structure: This compound features a chloromethyl group and a fluorine atom attached to a benzene ring, which can significantly influence its chemical behavior.
  • Functional Groups: The presence of both a halogen (chlorine) and a fluorine creates opportunities for intriguing substitution reactions, making this compound a valuable intermediate in synthesizing more complex organic molecules.
  • Applications in Synthesis: 1-(Chloromethyl)-2-fluoro-benzene is often utilized in the pharmaceutical industry where it can serve as a precursor in the synthesis of various bioactive compounds, particularly in the development of medicinal drugs.
  • Research Relevance: Due to its structural features, it is also a candidate for studies exploring electrophilic aromatic substitutions and the effects of halogens on reactivity patterns.
  • Environmental Impact: Compounds with such halogenated groups can raise concerns regarding environmental persistence and toxicity, resulting in ongoing research to better understand their potential effects.

In the words of a brilliant chemist, "The beauty of chemistry lies in the unexpected pathways that a single compound can reveal." 1-(Chloromethyl)-2-fluoro-benzene exemplifies this, showcasing a plethora of reactions and interactions that can lead to innovative applications and discoveries in diverse fields.

Synonyms
2-Fluorobenzyl chloride
345-35-7
1-(Chloromethyl)-2-fluorobenzene
O-FLUOROBENZYL CHLORIDE
alpha-Chloro-o-fluorotoluene
Benzene, 1-(chloromethyl)-2-fluoro-
1-Chloromethyl-2-fluoro-benzene
Toluene, alpha-chloro-o-fluoro-
EINECS 206-460-0
NSC 88295
DTXSID9059838
alpha-Chloro-2-fluorotoluene
2-fluorobenzylchloride
2-flourobenzyl chloride
MFCD00000892
o-fluorobenzylchloride
2-fluoro-benzyl chloride
NCIOpen2_001365
2-fluorophenylmethyl chloride
SCHEMBL69225
.alpha.-Chloro-o-fluorotoluene
2-Fluorobenzyl chloride, 98%
.alpha.-Chloro-2-fluorotoluene
DTXCID2038863
MOBRMRJUKNQBMY-UHFFFAOYSA-
NSC88295
Toluene, .alpha.-chloro-o-fluoro-
NSC-88295
STL183090
AKOS000119256
AC-10797
DB-023913
F0211
NS00041566
EN300-18207
F2190-0268
InChI=1/C7H6ClF/c8-5-6-3-1-2-4-7(6)9/h1-4H,5H2