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p-Fluorobenzyl chloride

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Identification
Molecular formula
C7H6ClF
CAS number
458-44-0
IUPAC name
1-(chloromethyl)-4-fluoro-benzene
State
State

At room temperature, p-Fluorobenzyl chloride is in a liquid state. It is volatile and should be handled in a well-ventilated environment or under a fume hood to avoid inhalation and exposure to its vapors.

Melting point (Celsius)
-6.00
Melting point (Kelvin)
267.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
142.58g/mol
Molar mass
142.5770g/mol
Density
1.1810g/cm3
Appearence

p-Fluorobenzyl chloride appears as a colorless to pale yellow liquid. It is a clear, transparent fluid with an appearance typical of many chloromethylated aromatic compounds. The liquid is often used in laboratory settings where its specific reactant properties are required.

Comment on solubility

Solubility of 1-(chloromethyl)-4-fluoro-benzene

1-(chloromethyl)-4-fluoro-benzene, a compound featuring a benzene ring substituted with both a chloromethyl and a fluorine group, exhibits interesting solubility characteristics that are influenced by its functional groups. Here are some key points related to its solubility:

  • Polarity: The introduction of both a chlorine atom and a fluorine atom affects the overall polarity of the molecule. Chlorine is more electronegative than carbon but less so than fluorine, which can contribute to a dipole moment.
  • Solvent Compatibility: While 1-(chloromethyl)-4-fluoro-benzene is generally more soluble in organic solvents due to its hydrophobic characteristics, it may encounter limitations in polar solvents like water. Specifically, it is typically not very soluble in water due to the compound's hydrophobic nature.
  • Hydrophobic Interactions: The benzene ring and the presence of the chloromethyl group lead to hydrophobic interactions, favoring solubility in non-polar solvents such as benzene, toluene, and other aromatic hydrocarbons.
  • Temperature Influence: Solubility may increase with temperature, as is typical for many organic compounds, but specific data would be necessary to quantify this behavior.

Overall, understanding the solubility of 1-(chloromethyl)-4-fluoro-benzene is crucial for its application in various chemical processes, underlining the importance of solvent selection in achieving desired outcomes.

Interesting facts

Interesting Facts about 1-(Chloromethyl)-4-fluoro-benzene

1-(Chloromethyl)-4-fluoro-benzene is a fascinating compound that belongs to the class of organic chemicals known as halogenated aromatic compounds. Here are some engaging facts that showcase its significance and applications in the field of chemistry:

  • Structure and Reactivity: This compound features a benzene ring substituted with both a chlorine atom and a fluorine atom. The presence of these halogen substituents greatly influences its reactivity, making it a versatile intermediate in various chemical reactions.
  • Industrial Applications: It is primarily used in the synthesis of pharmaceutical compounds and agrochemicals. Its structure allows for further functionalization, making it a valuable building block in the development of new drugs.
  • Research Significance: Scientists are particularly interested in compounds like 1-(chloromethyl)-4-fluoro-benzene for their roles in understanding reaction mechanisms and kinetics. These studies often aid in the design of more efficient synthesis pathways.
  • Toxicology and Environmental Concerns: As a halogenated compound, it is crucial to evaluate the safety and environmental impact of 1-(chloromethyl)-4-fluoro-benzene. Its chlorinated and fluorinated groups can lead to persistence in the environment, raising important questions regarding its degradation and bioaccumulation.
  • Potential in Green Chemistry: The challenge of utilizing such compounds in a sustainable manner has led to the exploration of "green" methodologies for their synthesis and use, aligning with the principles of reducing waste and minimizing harmful byproducts.

In summary, 1-(chloromethyl)-4-fluoro-benzene serves as an important example of how structural characteristics influence chemical behavior, and its ongoing study contributes significantly to both applied and theoretical chemistry.

Synonyms
4-Fluorobenzyl chloride
352-11-4
1-(Chloromethyl)-4-fluorobenzene
P-FLUOROBENZYL CHLORIDE
alpha-Chloro-p-fluorotoluene
Benzene, 1-(chloromethyl)-4-fluoro-
1-Chloromethyl-4-fluoro-benzene
alpha-Chloro-4-fluorotoluene
4-fluorobenzylchloride
1-Chloromethyl-4-fluorobenzene
EINECS 206-516-4
CCRIS 5107
MFCD00000913
NSC 25084
4-fluorobenzyl-d6 chloride
Toluene, alpha-chloro-p-fluoro-
1219804-13-3
4-Fluorobenzyl--d4 Chloride
DTXSID7059850
Toluene, .alpha.-chloro-p-fluoro-
4-FLUOROBENZYL-A,A-D2 CHLORIDE
A-CHLORO-4-FLUOROTOLUENE
4-fluoro benzyl chloride
4-fluorbenzylchlorid
4FBCl cpd
p-fluorobenzylchloride
pFluorobenzyl chloride
4-fluorobenzylchlorine
4fluorobenzyl chloride
parafluorobenzylchloride
4-fluorobenzyl-chloride
alphaChloropfluorotoluene
4-Fluoro-benzylchloride
alphaChloro4fluorotoluene
4-fluoro-benzyl chloride
4-fluoro-benzyl-chloride
1Chloromethyl4fluorobenzene
Toluene, alphachloropfluoro
4-fluorophenylmethyl chloride
1(Chloromethyl)4fluorobenzene
SCHEMBL186435
.alpha.-Chloro-p-fluorotoluene
4-Fluorobenzyl chloride, 99%
.alpha.-Chloro-4-fluorotoluene
DTXCID1038955
IZXWCDITFDNEBY-UHFFFAOYSA-
Toluene, alphachloropfluoro (8CI)
NSC25084
NSC-25084
STL197850
AKOS000119590
FF34655
Toluene, alpha-chloro-p-fluoro-(8CI)
DB-000228
F0204
NS00042104
EN300-18206
A25294
F96174
F2190-0253
1-(chloromethyl)-4-fluoro-benzen;Toluene, alpha-chloro-p-fluoro-
InChI=1/C7H6ClF/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2