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Cefotaxime

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Identification
Molecular formula
C16H17N5O7S2
CAS number
63527-52-6
IUPAC name
1-(cyclohexoxycarbonyloxy)ethyl 7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

Cefotaxime is in a solid state at room temperature.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
455.46g/mol
Molar mass
455.4610g/mol
Density
1.3605g/cm3
Appearence

Cefotaxime is typically a white or slightly yellow crystalline powder. It is almost insoluble in water and sparingly soluble in ethanol.

Comment on solubility

Solubility of 1-(cyclohexoxycarbonyloxy)ethyl 7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

The solubility of 1-(cyclohexoxycarbonyloxy)ethyl 7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate, with the chemical formula C16H17N5O7S2, can be influenced by several factors.

  • Polarity: Given that this compound contains multiple functional groups, such as amines and carboxylates, its overall polarity may allow for moderate solubility in polar solvents.
  • Hydrogen Bonding: The presence of amine and carboxylate functional groups suggests that hydrogen bonding is likely, enhancing solubility in aqueous solutions.
  • pH Sensitivity: The solubility may vary with the pH of the solution due to the ionization of the carboxyl group, making it more soluble in basic conditions.
  • Complexation: The potential for this compound to form complexes with metal ions or other molecules can affect its solubility characteristics significantly.

In summary, the solubility of this compound is a complex interplay of its molecular structure and environmental conditions, suggesting that while it may have some degree of solubility in polar solvents, the specific conditions must be optimized to achieve the desired solubility level. Understanding these factors is crucial for practical applications in pharmaceuticals and related fields.

Interesting facts

Interesting Facts about 1-(cyclohexoxycarbonyloxy)ethyl 7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This compound is a fascinating example of the complexity found in modern medicinal chemistry. It belongs to a class of chemical compounds known for their bioactivity and potential therapeutic applications. Here are some key highlights:

  • Multi-Functional Structure: The structure of this compound includes multiple functional groups that contribute to its biological activity. Notably, it contains a thiazole moiety, which is often associated with antimicrobial and anti-inflammatory properties.
  • Sulfanylmethyl Group: This unique group may enhance the compound’s reactivity or interaction with biological targets, making it of interest in the development of new drugs.
  • Amino Acids Role: The presence of amino-acid-like structures suggests that the compound could play a role in mimicking natural substrates in biochemical pathways.
  • Potential Therapeutic Uses: Compounds with similar structural features have been investigated for their effectiveness against various diseases, including cancer and infectious diseases.

As a student of chemistry, one can appreciate the intricate balance of structural and functional elements that can lead to potent biological activity. According to the famous chemist, “The most beautiful thing we can experience is the mysterious. It is the source of all true art and science.” The creation and study of this compound exemplify that philosophy, where the beauty of chemistry emerges from exploring complex structures that may lead to new discoveries.

In conclusion, 1-(cyclohexoxycarbonyloxy)ethyl 7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate encapsulates the innovative spirit of contemporary chemical research, highlighting the intertwined nature of chemistry, biology, and medicine.

Synonyms
CTM-HE;SCE-2174
ICX5607317
BRD-A76661185-300-01-6
BRD-A76661185-300-02-4