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1-Cyclohexyl-3-(indan-5-ylsulfonyl)urea

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Identification
Molecular formula
C14H15NO4S
CAS number
135410-20-7
IUPAC name
1-cyclohexyl-3-indan-5-ylsulfonyl-urea
State
State

1-Cyclohexyl-3-(indan-5-ylsulfonyl)urea is found in a solid state at room temperature.

Melting point (Celsius)
172.80
Melting point (Kelvin)
445.95
Boiling point (Celsius)
421.50
Boiling point (Kelvin)
694.65
General information
Molecular weight
332.42g/mol
Molar mass
332.4230g/mol
Density
1.3140g/cm3
Appearence

1-Cyclohexyl-3-(indan-5-ylsulfonyl)urea typically appears as an off-white to white crystalline powder.

Comment on solubility

Solubility of 1-cyclohexyl-3-indan-5-ylsulfonyl-urea

The solubility of 1-cyclohexyl-3-indan-5-ylsulfonyl-urea can be influenced by several factors related to its molecular structure and the nature of solvent interactions. Generally, this compound exhibits the following characteristics:

  • Polarity: Due to the presence of both the cyclohexyl and indan structures along with the sulfonyl and urea groups, the compound may display moderate polarity. This can affect its solubility in polar vs. non-polar solvents.
  • Solvent Type: It is likely to be more soluble in polar solvents such as alcohols or DMF (dimethylformamide) compared to non-polar solvents.
  • Hydrogen Bonding: The urea functional group can engage in hydrogen bonding, which may enhance solubility in protic solvents.
  • Temperature Dependency: Like many organic compounds, its solubility may increase with temperature, making it more soluble at elevated temperatures.

Overall, understanding the solubility of 1-cyclohexyl-3-indan-5-ylsulfonyl-urea is important for its practical applications in various fields, from pharmaceuticals to materials science. As with many compounds, the specific conditions, including pH and ionic strength of the solution, can also significantly influence its solubility behavior.

Interesting facts

Interesting Facts about 1-Cyclohexyl-3-Indan-5-Ylsulfonyl-Urea

1-Cyclohexyl-3-indan-5-ylsulfonyl-urea might seem like a mouthful, but this compound holds a special significance in the realms of medicinal chemistry and pharmacology.

Key Highlights:

  • Pharmaceutical Potential: This compound has demonstrated potential use as a therapeutic agent, particularly in the treatment of various diseases. Its unique structural features grant it the ability to interact with biological targets effectively.
  • Mechanism of Action: The sulfonylurea moiety plays a crucial role in its biological activity, often influencing the regulation of insulin secretion, making it interesting for diabetes research.
  • Structure-Activity Relationship: The distinct arrangement of the cyclohexyl and indan rings in its structure allows students and scientists alike to explore how modifications can enhance or alter its pharmacological effects.
  • Diverse Applications: Beyond diabetes, compounds in this class are being investigated for their anti-inflammatory and analgesic properties, highlighting their versatility.

“Chemistry is the art of transformation.” Understanding compounds like 1-cyclohexyl-3-indan-5-ylsulfonyl-urea illustrates this notion beautifully, as small changes in molecular structure can lead to significant alterations in biological function.

In conclusion, the study of 1-cyclohexyl-3-indan-5-ylsulfonyl-urea is not just about its chemical properties; it encompasses a broader understanding of how chemistry can be harnessed for life-changing applications. Its exploration can pave the way for advancements in drug design and therapeutic interventions.

Synonyms
GLYHEXAMIDE
451-71-8
Subose
SQ 15,860
Serbose
1-Cyclohexyl-3-(5-indanylsulfonyl)urea
SQ 15860
1-cyclohexyl-3-(2,3-dihydro-1H-inden-5-ylsulfonyl)urea
MLS002703949
WW7NA7WQD2
NSC-106960
SQ-15860
1H-Indene-5-sulfonamide, N-((cyclohexylamino)carbonyl)-2,3-dihydro-
HZ 21
NSC106960
1-cyclohexyl-3-indan-5-ylsulfonyl-urea
SMR001570661
Urea, 1-cyclohexyl-3-(5-indanylsulfonyl)-
UNII-WW7NA7WQD2
Glyhexamide [USAN:INN]
Glihexamida
Glyhexamid
Subose (TN)
NSC 106960
GLYHEXAMIDE [MI]
GLYHEXAMIDE [INN]
Glyhexamide (USAN/INN)
GLYHEXAMIDE [USAN]
cid_9953
SCHEMBL185244
CHEMBL1968544
BDBM91416
DTXSID70196383
CHEBI:135369
AAA45171
1H-Indene-5-sulfonamide,3-dihydro-
GS4040
HY-U00012
AKOS040740800
CS-6613
DA-73811
NCI60_000166
NS00123729
D04354
5-((((Cyclohexylamino)carbonyl)amino)sulfonyl)indane
Q27292949
1-CYCLOHEXYL-3-(2,3-DIHYDRO-1H-INDENE-5-SULFONYL)UREA
1H-Indene-5-sulfonamide, {N-[(cyclohexylamino)carbonyl]-2,3-dihydro-}