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cyclohexyl(p-tolylsulfonyl)urea

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Identification
Molecular formula
C14H20N2O3S
CAS number
22204-53-1
IUPAC name
1-cyclohexyl-3-(p-tolylsulfonyl)urea
State
State

The compound is typically a solid under room temperature conditions.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
338.50
Boiling point (Kelvin)
611.65
General information
Molecular weight
306.38g/mol
Molar mass
306.3840g/mol
Density
1.3500g/cm3
Appearence

Cyclohexyl(p-tolylsulfonyl)urea typically appears as a crystalline powder. Its color ranges from white to off-white depending on the purity and specific conditions during synthesis. The compound is generally solid at room temperature.

Comment on solubility

Solubility of 1-cyclohexyl-3-(p-tolylsulfonyl)urea

The compound 1-cyclohexyl-3-(p-tolylsulfonyl)urea exhibits unique solubility characteristics due to its specific molecular structure. This urea derivative is known to have varying solubility in different solvents:

  • Water: Generally, compounds containing urea functional groups can exhibit some degree of solubility in water. However, the presence of bulky cyclohexyl and p-tolylsulfonyl groups may hinder full solvation, leading to limited solubility in aqueous environments.
  • Organic Solvents: This compound tends to be more soluble in organic solvents such as dichloromethane, acetone, and ethyl acetate, where it can interact favorably with the solvent molecules.
  • Polar and Non-Polar Solvents: The diverse nature of the substituents might allow it to dissolve in a range of polar and non-polar solvents, which is advantageous for various chemical applications.

It's crucial to note that factors such as temperature, solvent polarity, and intermolecular interactions play significant roles in determining the solubility of 1-cyclohexyl-3-(p-tolylsulfonyl)urea. As a general observation:

  • Higher temperatures usually increase solubility in organic solvents.
  • Protonation or ionization can enhance solubility in polar solvents.

Always consider these elements when evaluating the solubility of this compound in various conditions.

Interesting facts

Interesting Facts About 1-Cyclohexyl-3-(p-tolylsulfonyl)urea

1-Cyclohexyl-3-(p-tolylsulfonyl)urea, often recognized in the field of organic chemistry for its unique structure and applications, is a fascinating compound with a variety of interesting properties and uses.

Key Points of Interest:

  • Synthesis: This compound is typically synthesized through a series of reactions involving cyclohexyl amine and p-tolylsulfonyl isocyanate. Its formation is a great example of how functional groups can influence molecular properties.
  • Biological Activity: Research has indicated that compounds like 1-cyclohexyl-3-(p-tolylsulfonyl)urea exhibit interesting biological activities, making them candidates for pharmaceuticals, particularly in anti-inflammatory and analgesic therapies.
  • Applications: Beyond medicinal uses, this compound can also be utilized in agricultural chemistry, serving as a herbicide or pesticide in certain formulations, thus showcasing its versatility in chemical applications.
  • Structure-Activity Relationship: The presence of both the cyclohexyl group and the p-tolylsulfonyl moiety contributes significantly to the compound's properties. Understanding how these groups interact at the molecular level is crucial for the design of new derivatives.

In conclusion, 1-cyclohexyl-3-(p-tolylsulfonyl)urea is not just a compound with a complex name; it is a representative of the intricate interplay between structure and function in medicinal chemistry. As one researcher noted, "The confluence of various functional groups in organic synthesis opens endless possibilities for innovation."

Synonyms
Glycyclamide
TOLCYCLAMIDE
664-95-9
Cychloral
Cyclamid
Gliciclamide
Glycyclamid
Tolhexamide
Agliral
Glicosil
Gliciclamida
Glycyclamide [INN]
Glycyclamidum
Gliciclamide [DCIT]
1-Cyclohexyl-3-p-tolylsulfonylurea
Glycyclamidum [INN-Latin]
Gliciclamida [INN-Spanish]
1-Cyclohexyl-3-p-toluenesulfonylurea
1-(p-Tolylsulfonyl)-3-cyclohexylurea
N-Cyclohexyl-N'-(p-tolylsulfonyl)urea
N-(4-Tolylsulfonyl)-N'-cyclohexylurea
Urea, 1-cyclohexyl-3-(p-tolylsulfonyl)-
K 386
K-386
EINECS 211-557-6
UNII-C40N4EJY68
N-(4-Methylbenzenesulfonyl)-N'-cyclohexylurea
NSC 142661
NSC-142661
BRN 1995860
Glycyclamide (INN)
DTXSID5046273
1-Cicloesil-3-p-tolilsolfonilurea
1-Cicloesil-3-p-tolilsolfonilurea [Italian]
TOLCYCLAMIDE [MI]
GLYCYCLAMIDE [MART.]
GLYCYCLAMIDE [WHO-DD]
Benzenesulfonamide, N-((cyclohexylamino)carbonyl)-4-methyl-
DTXCID3026273
4-12-00-00057 (Beilstein Handbook Reference)
Glycyclamidum (INN-Latin)
Gliciclamida (INN-Spanish)
GLYCYCLAMIDE (MART.)
Benzenesulfonamide, N-[(cyclohexylamino)carbonyl]-4-methyl-
1-cyclohexyl-3-tosylurea
Diabomet
Diaborale
1-Cyclohexyl-3-p-tolylsulphonylurea
1-cyclohexyl-3-(p-toluenesulfonyl)urea
Benzenesulfonamide, N-((cyclohexylamino)carbonyl)-4-methyl-(9CI)
211-557-6
cicloral
Cyclamide
1-cyclohexyl-3-(4-methylphenyl)sulfonylurea
K-38
C40N4EJY68
NCGC00160649-01
N-(cyclohexylcarbamoyl)-4-methylbenzenesulfonamide
Cyclamide [Russian]
CAS-664-95-9
SR-01000945146
Tolcyclamide K 38
Oprea1_220838
Oprea1_641283
SCHEMBL49386
WLN: L6TJ AMVMSWR D1
CHEMBL312394
N-[(Cyclohexylamino)carbonyl]-4-methylbenzenesulfonamide
SCHEMBL19925500
CHEBI:135251
RIGBPMDIGYBTBJ-UHFFFAOYSA-N
Tox21_111956
GS4037
NSC142661
STK041315
AKOS001218044
Tox21_111956_1
CCG-357214
NCGC00160649-02
DS-010299
HY-119982
CS-0078864
NS00036043
D02426
SR-01000945146-1
SR-01000945146-2
Q17631916
Z44585883
Benzenesulfonamide,n-[(cyclohexylamino)carbonyl]-4-methyl-