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1-Cyclohexylpiperidine

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Identification
Molecular formula
C11H21N
CAS number
3319-01-5
IUPAC name
1-cyclohexylpiperidine
State
State

1-Cyclohexylpiperidine is in a liquid state at room temperature, characterized by its clear to pale yellow appearance. It is stable under normal conditions and has a slightly oily consistency.

Melting point (Celsius)
-3.00
Melting point (Kelvin)
270.15
Boiling point (Celsius)
239.00
Boiling point (Kelvin)
512.15
General information
Molecular weight
167.30g/mol
Molar mass
167.2800g/mol
Density
0.9170g/cm3
Appearence

1-Cyclohexylpiperidine typically appears as a clear to pale yellow liquid. Depending on purity and ambient conditions, it can occasionally exhibit slight discoloration. It is an organic compound known for its liquid state at standard room temperature and pressure.

Comment on solubility

Solubility of 1-Cyclohexylpiperidine

1-Cyclohexylpiperidine is a unique compound with noteworthy solubility characteristics. Its solubility can primarily be attributed to its organic structure, which includes a piperidine ring attached to a cyclohexyl group. Here are several key points regarding its solubility:

  • Solvent Interactions: 1-Cyclohexylpiperidine exhibits relatively good solubility in polar organic solvents such as ethanol and methanol.
  • Insolubility in Water: This compound is generally insoluble in water, a characteristic common to many organic amines.
  • Temperature Effects: Temperature can significantly impact its solubility; typically, increasing temperature enhances solubility in organic solvents.
  • Chemical Reactions: Upon reacting with acids, it may form salts which often exhibit improved solubility in aqueous solutions.

As a result, while 1-cyclohexylpiperidine is less soluble in water, its performance in non-aqueous solvents is quite favorable, making it versatile for various applications. Remember, “solubility is not merely a question of amount dissolved, but rather the intrinsic properties of the solute and solvent." As you explore further, keep the diverse solubility profiles of compounds in mind, as they play a crucial role in their applications in chemistry.

Interesting facts

Interesting Facts about 1-Cyclohexylpiperidine

1-Cyclohexylpiperidine is a fascinating compound with a structure that opens up numerous avenues for research and application. This compound consists of a piperidine ring, a six-membered nitrogen-containing heterocycle, which is a versatile template in medicinal chemistry.

Key Highlights

  • Therapeutic Potential: 1-Cyclohexylpiperidine has garnered interest due to its potential applications in developing pharmaceutical agents, particularly as a central nervous system (CNS) stimulant.
  • Structural Diversity: The cyclohexyl group adds a layer of complexity and can influence the compound's interaction with various biological targets, enhancing its potential efficacy.
  • Analog Studies: Researchers often study this compound in relation to its analogs to explore structure-activity relationships (SARs), which can lead to the discovery of new drugs with improved properties.
  • Receptor Interaction: Investigations have pointed out its potential interactions with neurotransmitter receptors, which makes it a subject of interest for neuropharmacological research.

In addition to its chemical significance, 1-cyclohexylpiperidine serves as an intriguing case study for students and researchers exploring the realms of organic synthesis and medicinal chemistry. The compound illustrates how small changes in molecular structure can lead to substantial differences in biological activity—a concept that is foundational in the design of new pharmaceuticals.

As you delve into the chemistry of 1-cyclohexylpiperidine, consider the following:

  • The role of nitrogen in biological systems.
  • Strategies for synthesizing complex organic molecules.
  • The interplay between chemical structure and biological function.

With its unique structure and promising properties, 1-cyclohexylpiperidine is a compound that inspires curiosity and innovation in the field of chemistry.

Synonyms
1-Cyclohexylpiperidine
Cyclohexylpiperidine
N-Cyclohexylpiperidine
PIPERIDINE, 1-CYCLOHEXYL-
EINECS 222-016-9
NSC 93942
BRN 0105594
CHEBI:38897
DTXSID60186839
5-20-02-00040 (Beilstein Handbook Reference)
DTXCID50109330
222-016-9
dsskltahhalfrw-uhfffaoysa-n
3319-01-5
1-Piperidinocyclohexane
NSC-93942
NSC93942
MFCD00014642
1-cyclohexyl-piperidine
1-Piperidinylcyclohexane
FB3LR8GN9P
SCHEMBL60131
WLN: T6NTJ A- AL6TJ
STL484262
AKOS006229402
SB41086
AS-57827
DB-019142
C3032
NS00029431
D89530
Q27118026