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Metaraminol

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Identification
Molecular formula
C9H13N3O
CAS number
54-49-9
IUPAC name
1-(diaminomethylene)-2-(2-phenylethyl)guanidine
State
State

Solid at room temperature. The compound is often provided in its hydrochloride salt form which is crystalline in nature.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.15
Boiling point (Celsius)
234.50
Boiling point (Kelvin)
507.65
General information
Molecular weight
195.22g/mol
Molar mass
195.2660g/mol
Density
1.3000g/cm3
Appearence

Crystalline powder or colorless crystals. It may also be available as a solution for injection. It is usually odorless or may have a slight specific odor.

Comment on solubility

Solubility of 1-(diaminomethylene)-2-(2-phenylethyl)guanidine

The solubility of 1-(diaminomethylene)-2-(2-phenylethyl)guanidine can be quite interesting to consider due to its structural features. This compound, which contains both guanidine and an aromatic component, may exhibit unique solubility characteristics based on its functional groups.

Factors Influencing Solubility:

  • Polarity: The presence of functional groups like amino groups can enhance solubility in polar solvents such as water.
  • Hydrophobic Interactions: The phenylethyl group may contribute to hydrophobic interactions, which might limit solubility in highly polar solvents.
  • pH Dependence: The solubility can be affected by pH, as the guanidine moiety can become protonated, increasing solubility in acidic conditions.

In general:

  • It is likely to be soluble in water and organic solvents that can stabilize its structure.
  • May demonstrate limited solubility in non-polar solvents due to its hydrophilic guanidine group.

Understanding the solubility of this compound is essential, as it can play a significant role in applications ranging from pharmaceuticals to materials science. As with many organic compounds, experimental determination is crucial to fully elucidate its solubility properties in various environments.

Interesting facts

Interesting Facts about 1-(Diaminomethylene)-2-(2-phenylethyl)guanidine

1-(Diaminomethylene)-2-(2-phenylethyl)guanidine is a compelling compound that piques the interest of chemists and researchers alike due to its unique structural features and potential applications.

Structural Insights

This compound contains a guanidine core, which is known for its basic properties and ability to form hydrogen bonds. Its structure includes:

  • Diaminomethylene functionality: This feature enhances reactivity, making it suitable for various chemical reactions.
  • Phenylethyl group: This aromatic component provides interesting electronic properties and can influence the compound's interaction with biological systems.

Biological Significance

The guanidine group has been of interest in medicinal chemistry because:

  • It exhibits potential as an active pharmaceutical ingredient.
  • Compounds with similar structures have been associated with effects on neurotransmitter systems, showcasing promise in treating certain neurological disorders.

Reactivity and Applications

The presence of multiple amine groups in the structure allows this compound to:

  • Participate in a wide range of reactions, including nucleophilic substitution and condensation reactions.
  • Serve as a building block in the synthesis of more complex organic molecules, aiding in the advancement of organic synthesis methodologies.

In conclusion, 1-(Diaminomethylene)-2-(2-phenylethyl)guanidine is more than just a compound; it embodies the intersection of structural uniqueness and potential utility in various fields such as medicinal chemistry and organic synthesis. As we continue to explore its properties, we may uncover even more exciting applications and interactions within biological systems.

Synonyms
PHENFORMIN
114-86-3
N-Phenethylbiguanide
Fenformin
Phenformine
Fenformina
Phenethyldiguanide
Phenylethylbiguanide
Cronoformin
Fenfoduron
Fenormin
Glukopostin
Phenformix
Debeone
Diabis
Dibiraf
Dibotin
Glyphen
Retardo
Imidodicarbonimidic diamide, N-(2-phenylethyl)-
Pedg
Db-retard
Feguanide
Lentobetic
Normoglucina
Azucaps
beta-PEBG
Debinyl
Dibein
Insoral
DB Comb
1-Phenethylbiguanide
D Bretard
beta-Phenethylbiguanide
Phenforminum
Fenformina [INN-Spanish]
Phenformine [INN-French]
Phenforminum [INN-Latin]
Biguanide, 1-phenethyl-
beta-Phenethybiguanide
N-(2-Phenylethyl)imidodicarbonimidic diamide
Phenformin [INN:BAN]
Phenformin (BAN)
NCI-C01741
CCRIS 500
Phenethylbiguanide
CHEBI:8064
N'-beta-Phenethylformamidinylliminourea
HSDB 3154
W 32
N'-beta-Fenetilformamidiniliminourea
EINECS 204-057-4
UNII-DD5K7529CE
N'-beta-Fenetilformamidiniliminourea [Italian]
Dipar (Salt/Mix)
BRN 1977317
DD5K7529CE
.beta.-PEBG
1-carbamimidamido-N-(2-phenylethyl)methanimidamide
Meltrol (Salt/Mix)
PHENFORMIN [MI]
PHENFORMIN [INN]
.beta.-Phenethylbiguanide
MFCD00242966
PHENFORMIN [HSDB]
PHENFORMIN [VANDF]
1-(diaminomethylidene)-2-(2-phenylethyl)guanidine
PHENFORMIN [WHO-DD]
N-Phenethylbiguanide hydrochloride
CHEMBL170988
DTXSID1023449
4-12-00-02472 (Beilstein Handbook Reference)
2-(N-phenethylcarbamimidoyl)guanidine
N'-.beta.-Fenetilformamidiniliminourea
114-86-3 (FREE BASE)
N'-.beta.-Phenethylformamidinylliminourea
Phenformine HCl
Fenformina (INN-Spanish)
Phenformine (INN-French)
Phenforminum (INN-Latin)
NCGC00016543-01
CAS-834-28-6
1-Phenethylbiguanide hydrochloride (Phenformin)
(phenylethyl)biguanide
Prestwick0_000179
Prestwick1_000179
Prestwick2_000179
Prestwick3_000179
SCHEMBL8424
BSPBio_000077
KBioGR_002392
KBioSS_002397
MLS006011899
SPBio_001998
BPBio1_000085
DTXCID903449
SCHEMBL10325620
SCHEMBL17300524
KBio2_002392
KBio2_004960
KBio2_007528
KBio3_002871
cMAP_000038
HMS3604G03
ALBB-026048
AC3005
BBL010845
BDBM50237608
BDBM50240908
NSC756501
STK635703
1-carbamimidoyl-3-phenethyl-guanidine
AKOS005567415
DB00914
NSC-756501
SDCCGSBI-0206879.P005
NCGC00016543-02
NCGC00016543-03
NCGC00016543-04
NCGC00016543-05
NCGC00016543-08
CS-11859
DA-56792
HY-16397
SMR004703510
SY031759
N-(2-Phenylethyl)dicarbonimidic diamide #
SBI-0206879.P001
CS-0006321
NS00001680
C07673
D08351
EN300-7418232
Q753100
N''''-{amino[(2-phenylethyl)imino]methyl}guanidine
BRD-K11399644-003-03-0
BRD-K11399644-003-09-7
BRD-K11399644-003-10-5
BRD-K11399644-003-11-3
N-(2-phenylethyl)imidodicarbonimidic diamide(Phenformin)
Imidodicarbonimidic diamide, N-(2-phenylethyl)-, hydrochloride
N''''-[(E)-amino(imino)methyl]-N-(2-phenylethyl)guanidine
N-amino(imino)methyl-N-phenethyliminomethanediamine(Phenformin)
204-057-4
8CV