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Nifurfoline

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Identification
Molecular formula
C8H9N5O2
CAS number
23595-57-9
IUPAC name
1-(diaminomethylene)-2-(3-nitrophenyl)guanidine
State
State

At room temperature, Nifurfoline exists as a solid. It is typically stored in sealed containers to prevent degradation and maintain stability.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
408.00
Boiling point (Kelvin)
681.15
General information
Molecular weight
238.19g/mol
Molar mass
238.2150g/mol
Density
1.3910g/cm3
Appearence

Nifurfoline is typically an orange crystalline solid, which may appear slightly brownish due to its nitro compound nature. The crystals have a well-defined geometry and may vary in size but generally keep a crystalline structure.

Comment on solubility

Solubility of 1-(diaminomethylene)-2-(3-nitrophenyl)guanidine

1-(diaminomethylene)-2-(3-nitrophenyl)guanidine is a compound that exhibits particular solubility characteristics due to its molecular structure. Understanding its solubility is essential for various applications in chemical and biological contexts.

Key Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups in the molecule affects its solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds can greatly increase its solubility in aqueous environments.
  • pH Sensitivity: Changes in pH can influence the ionization state of the compound, thereby affecting its solubility profile.

It is often noted that compounds containing nitrophenyl groups tend to be less soluble in non-polar solvents. Therefore, one might find:

Typical Solubility Observations:

  • Slightly soluble in water: Due to the polar guanidine functional group.
  • Better solubility in organic solvents: Such as ethanol and acetone, which can favorably interact with the aromatic portions of the molecule.

In conclusion, the solubility of 1-(diaminomethylene)-2-(3-nitrophenyl)guanidine is influenced by its molecular interactions and the nature of the solvent used. This information is invaluable for practical applications, such as in synthesis and pharmaceutical formulations.

Interesting facts

Interesting Facts about 1-(diaminomethylene)-2-(3-nitrophenyl)guanidine

1-(diaminomethylene)-2-(3-nitrophenyl)guanidine is a fascinating compound with a number of noteworthy characteristics. Here are some highlights:

  • Versatile Building Block: This compound is often used as a precursor in various synthetic pathways. Its unique structure makes it an essential intermediate in the synthesis of pharmaceuticals and agrochemicals.
  • Bioactivity: Research shows that compounds similar to 1-(diaminomethylene)-2-(3-nitrophenyl)guanidine can exhibit anti-inflammatory and antitumor activities, making them of great interest in medicinal chemistry.
  • Exploration in Material Science: The compound's nitrogen-rich structure lends itself to applications in material science, especially in the development of energetic materials, which are critical in fields such as defense and space exploration.
  • Environmental Functionality: With increasing focus on sustainable chemistry, compounds like 1-(diaminomethylene)-2-(3-nitrophenyl)guanidine are explored for their potential in environmental applications, such as in the detoxification of hazardous materials.
  • Chemical Properties: The presence of the nitrophenyl group introduces unique electronic properties, making this compound a subject of study for understanding electronic effects in aromatic systems.

In conclusion, 1-(diaminomethylene)-2-(3-nitrophenyl)guanidine is not just a compound of theoretical interest, but one with a wide array of practical implications in various scientific fields. Its contributions to drug development, material science, and environmental chemistry highlight its significance in contemporary research.

Synonyms
N-(3-nitrophenyl)imidodicarbonimidic diamide
10441-20-0
DTXSID00274688
DTXCID60203454
1-(diaminomethylidene)-2-(3-nitrophenyl)guanidine
3-Nitro-Phenyl biguanide
imidodicarbonimidic diamide, n-(3-nitrophenyl)-
CHEMBL42538
1-CARBAMIMIDAMIDO-N-(3-NITROPHENYL)METHANIMIDAMIDE
m-Nitrophenylbiguanid
MFCD00448708
ALBB-022026
BDBM50053592
STK135617
AKOS002227762
LS-06773
PD129488
N-(3-nitrophenyl)imidodicarbonimidicdiamide
CS-0329774
H33359
SR-01000268476
SR-01000268476-1
1-{[{[AMINO(IMINO)METHYL]AMINO}(IMINO)METHYL]AMINO}-3-NITROBENZENE