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Nitrofurazone

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Identification
Molecular formula
C8H9N3O3
CAS number
59-87-0
IUPAC name
1-(diaminomethylene)-2-(4-ethoxyphenyl)guanidine
State
State

At room temperature, Nitrofurazone is typically solid, appearing as a crystalline powder. However, in medical use, it is often found in ointment form, which is a semi-solid state.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.15
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
229.22g/mol
Molar mass
229.2160g/mol
Density
1.1140g/cm3
Appearence

Nitrofurazone is typically a yellow crystalline powder. It is known for its bright color. The compound is often used in an ointment form, where it may appear as a smooth, semi-solid substance.

Comment on solubility

Solubility of 1-(diaminomethylene)-2-(4-ethoxyphenyl)guanidine

The solubility of 1-(diaminomethylene)-2-(4-ethoxyphenyl)guanidine is a significant factor to consider in its applications and interactions in various environments. The compound showcases varying solubility characteristics depending on the medium in which it is present. Here are some key points regarding its solubility:

  • Water Solubility: This compound tends to exhibit moderate solubility in water, primarily due to the presence of polar amine groups that can interact favorably with water molecules.
  • Organic Solvents: It is generally less soluble in non-polar organic solvents, which can limit its application in certain organic synthesis scenarios.
  • Influence of pH: The solubility may also be influenced by the pH of the solution; increased acidity can facilitate solubility through protonation of amine groups, while increased basicity might have the opposite effect.

In summary, understanding the solubility parameters of 1-(diaminomethylene)-2-(4-ethoxyphenyl)guanidine is essential for optimizing its usage in chemical processes. As the saying goes, "the solvent makes the solute", and knowing how this compound behaves in different solvents can lead to better integration into experimental protocols and product formulations.

Interesting facts

Interesting Facts about 1-(Diaminomethylene)-2-(4-ethoxyphenyl)guanidine

1-(Diaminomethylene)-2-(4-ethoxyphenyl)guanidine is a fascinating chemical compound that showcases the intricate interplay between molecular structure and biological activity. Here are some intriguing aspects of this compound:

  • Pharmaceutical Potential: This compound belongs to a class of guanidine derivatives that have been explored for their potential therapeutic applications. Its unique structure suggests possibilities in areas such as anti-inflammatory and antimicrobial therapies.
  • Molecular Versatility: The presence of both the guanidine and aromatic ethoxy group contributes to its reactivity, enhancing its ability to form bonds with various biological targets. This property is crucial for drug design and development.
  • Structure-Activity Relationship (SAR): Understanding the relationship between its molecular structure and biological function is vital. This compound serves as a prime example for studying how modifications can influence activity, offering insights for future synthetic advancements.
  • Research Interest: Recent studies have highlighted the interest in guanidine derivatives for their role in neuroprotection, demonstrating potential in the treatment of neurodegenerative diseases.
  • Synthesis and Characterization: The synthesis of 1-(diaminomethylene)-2-(4-ethoxyphenyl)guanidine involves intricate organic reactions, making it a captivating project for chemistry students aiming to deepen their practical skills in organic synthesis.

In conclusion, 1-(diaminomethylene)-2-(4-ethoxyphenyl)guanidine stands out not just for its intriguing molecular characteristics, but also for its potential impact in the realm of medicinal chemistry. As researchers continue to unravel the properties of this compound, it holds promise for significant advancements in drug discovery and development.

Synonyms
N-(4-ethoxyphenyl)imidodicarbonimidic diamide
43191-42-0
RefChem:361953
Imidodicarbonimidic diamide, N-(4-ethoxyphenyl)-
1-(diaminomethylidene)-2-(4-ethoxyphenyl)guanidine
SCHEMBL4099843
DTXSID001251810
HMS1595P15
STK107829
AKOS002224798
ST50106263
amino{[(4-ethoxyphenyl)amino]iminomethyl}carboxamidine
1-{[{[AMINO(IMINO)METHYL]AMINO}(IMINO)METHYL]AMINO}-4-ETHOXYBENZENE