Skip to main content

Furaguanidine

ADVERTISEMENT
Identification
Molecular formula
C8H12N4O
CAS number
80-97-7
IUPAC name
1-(diaminomethylene)-2-[(5-methyl-2-furyl)methyl]guanidine
State
State

At room temperature, furaguanidine is in a solid state, typically found as a crystalline powder. It is not volatile and has no significant vapor pressure at room temperature.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
405.00
Boiling point (Kelvin)
678.15
General information
Molecular weight
179.20g/mol
Molar mass
179.1920g/mol
Density
1.3800g/cm3
Appearence

Furaguanidine typically appears as a white to off-white crystalline powder. Its color can sometimes vary slightly towards a yellowish tint, especially when impure or aged due to oxidation of the furan ring.

Comment on solubility

Solubility of 1-(diaminomethylene)-2-[(5-methyl-2-furyl)methyl]guanidine

The solubility of 1-(diaminomethylene)-2-[(5-methyl-2-furyl)methyl]guanidine is influenced by various factors including temperature, pH, and the presence of other solvents. Given its complex structure, it exhibits a few interesting characteristics:

  • Polar Nature: Due to the presence of amino groups, the compound is likely to exhibit polar characteristics, which may enhance its solubility in polar solvents like water.
  • Solvent Compatibility: It may have varied solubility in organic solvents, depending on the solvent's polarity. For instance, alcohols or dimethyl sulfoxide (DMSO) may show better solubility compared to non-polar solvents.
  • pH Dependence: The solubility can also be heavily dependent on pH levels; at certain pH values, the amino groups can become protonated, which may increase solubility in aqueous environments.

Research indicates that the solubility of such guanidine derivatives can lead to enhanced pharmacokinetics in medicinal chemistry. However, precise solubility data may be limited, and empirical testing is often necessary to fully understand its behavior in solution.

In summary, while insights can be drawn from the structure of 1-(diaminomethylene)-2-[(5-methyl-2-furyl)methyl]guanidine, experimental solubility assessments are crucial for practical applications.

Interesting facts

Interesting Facts about 1-(Diaminomethylene)-2-[(5-methyl-2-furyl)methyl]guanidine

This intriguing compound, often referred to as DMF-guadinine, showcases the fascinating interplay between organic chemistry and pharmacology.

Key Features:

  • Structural Complexity: The presence of a guanidine group coupled with a furyl moiety makes this compound structurally unique. The guanidine scaffold is well-known for its significant biological activities.
  • Biological Relevance: Compounds that contain guanidine groups have been extensively studied for their role in pharmaceutical applications, including their potential as antihypertensive agents.
  • Integration of Furan: The 5-methyl-2-furyl group adds an aromatic component that may enhance the compound's reactivity and binding to biological targets, making it an interesting subject for drug design.

As a student of chemistry, one might consider the implications of combining nitrogen-rich functional groups with heterocyclic rings. The structural arrangement allows for diverse interactions within enzymatic and receptor sites, potentially leading to favorable therapeutic effects.

Applications and Research:

  • Drug Development: Research into the synthesis of DMF-guadinine can provide insights into new classes of drugs targeting various diseases.
  • Material Science: Due to its chemical properties, similar compounds have applications in developing smart materials and sensors.
  • Organic Synthesis: The methodologies employed to synthesize this compound often utilize green chemistry principles, aligning with modern sustainable practices in chemical manufacturing.

In conclusion, 1-(diaminomethylene)-2-[(5-methyl-2-furyl)methyl]guanidine serves as a prime example of how intricate structures can lead to the development of innovative and effective compounds in the field of medicinal chemistry. This compound not only exemplifies rich chemical diversity but also highlights the ongoing quest for effective therapeutic agents.

Synonyms
SCHEMBL6694826
1-(5-Methylfurfuryl) Biguanide
PDNMSYJCDHLCRW-UHFFFAOYSA-N
AKOS021354817