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Metformin hydrochloride

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Identification
Molecular formula
C4H12ClN5
CAS number
1115-70-4
IUPAC name
1-(diaminomethylene)-2-isobutyl-guanidine;hydrochloride
State
State
Metformin hydrochloride is typically a solid at room temperature. It is used widely in its solid form in pharmaceutical applications, especially in the formulation of oral tablets.
Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
539.00
Boiling point (Kelvin)
812.15
General information
Molecular weight
165.63g/mol
Molar mass
165.6250g/mol
Density
1.0700g/cm3
Appearence

Metformin hydrochloride appears as a white crystalline powder. It is generally odorless and hygroscopic in nature. The compound is highly soluble in water and slightly soluble in alcohol, but it is insoluble in acetone and methylene chloride.

Comment on solubility

Solubility of 1-(Diaminomethylene)-2-isobutyl-guanidine; Hydrochloride

The solubility of 1-(diaminomethylene)-2-isobutyl-guanidine; hydrochloride is an important aspect to consider, particularly in the context of its applications in chemical and pharmaceutical fields. This compound is known to be soluble in water, which significantly enhances its accessibility for biological systems and various experimental setups.


Factors Affecting Solubility

  • pH of the Solution: The solubility of this hydrochloride salt may be influenced by the pH of the environment. Generally, protonated forms in acidic conditions are more soluble.
  • Temperature: Increasing temperature often enhances solubility, making this compound more soluble at higher temperatures.
  • Presence of Other Ions: The solubility can also be affected by the presence of other ions in the solution, which may compete or interact with the compound's ionic structure.

In summary, the solubility characteristics of 1-(diaminomethylene)-2-isobutyl-guanidine; hydrochloride make it a versatile compound in research and applications. Its favorable solubility in aqueous solutions is particularly beneficial for its use in biochemical studies and therapeutic areas, allowing for easy formulation and dosing!

Interesting facts

Interesting Facts about 1-(Diaminomethylene)-2-isobutyl-guanidine Hydrochloride

1-(Diaminomethylene)-2-isobutyl-guanidine hydrochloride is a fascinating compound that stands out in the realm of pharmaceutical chemistry. Here are some intriguing insights about this compound:

  • Pharmacological Relevance: This compound has been studied for its potential therapeutic effects, particularly in the management of blood pressure. It may function as an antihypertensive agent, showcasing its importance in cardiovascular health.
  • Guanidine Derivative: As a guanidine derivative, it possesses unique structural features that contribute to its biological activity. Guanidine compounds are known for their role in various biochemical processes, including energy metabolism.
  • Mechanism of Action: This compound is believed to operate by influencing the nitric oxide pathway, thus facilitating vasodilation—a process that helps to lower blood pressure by widening blood vessels.
  • Research Potential: The ongoing research into this compound is promising, with studies investigating its effects on not only hypertension but also other conditions related to vascular health.
  • Preparation and Synthesis: The synthesis of this compound involves multi-step chemical reactions that require a good understanding of organic chemistry concepts, particularly involving amines and guanidines. This offers an exciting challenge for chemistry students!

In the words of one researcher, "The exploration of novel guanidine derivatives offers a tantalizing glimpse into the future of therapeutic agents that can significantly impact human health."
The continued study of 1-(diaminomethylene)-2-isobutyl-guanidine hydrochloride not only contributes to our understanding of pharmacology but also bolsters the field of medicinal chemistry as a whole.

Synonyms
iBuB hydrochloride
924-84-5
BIGUANIDE, 1-ISOBUTYL-, MONOHYDROCHLORIDE
1-Isobutylbiguanide monohydrochloride
NSC140880
NSC-140880
NSC 140880
AI3-51266
CHEMBL1993053
DTXSID50238992
Imidodicarbonimidic diamide, N-(2-methylpropyl)-, monohydrochloride