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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
34552-83-5
IUPAC name
1-(diethylaminomethyl)propyl 2,2-diphenylacetate
State
State

At room temperature, loperamide is a solid. It is not volatile, and it maintains its solid crystalline form under standard conditions of temperature and pressure.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
517.00
Boiling point (Kelvin)
790.15
General information
Molecular weight
477.03g/mol
Molar mass
477.0340g/mol
Density
0.9245g/cm3
Appearence

Loperamide is typically seen as white or off-white crystalline powder, making it appear as a fine powdery substance at first glance. It is odorless or may have a faint characteristic odor.

Comment on solubility

Solubility of 1-(diethylaminomethyl)propyl 2,2-diphenylacetate

The compound 1-(diethylaminomethyl)propyl 2,2-diphenylacetate, with the chemical formula C29H33ClN2O2, presents some intriguing characteristics regarding its solubility. Understanding the solubility of such a compound is essential for its applications in chemical processes.

Solubility Characteristics

This compound is a complex organic molecule, and its solubility can be influenced by several factors:

  • Polarity: Given its substantial molecular weight and branched structure, the overall polarity of the molecule plays a significant role in its interactions with solvents.
  • Functional Groups: The presence of both aromatic and aliphatic segments can lead to varied solubility in polar and non-polar solvents. Typically, compounds with similar parts will dissolve better in similar solvents.
  • Hydrophobic Interactions: The diphenylacetate part contributes to significant hydrophobic characteristics, potentially making the compound less soluble in water but more soluble in organic solvents.

It is often stated that "like dissolves like," and this principle holds true for 1-(diethylaminomethyl)propyl 2,2-diphenylacetate. Therefore, you might expect:

  • High solubility in organic solvents such as ethanol, acetone, or dichloromethane.
  • Limited solubility in water due to its bulky hydrophobic groups.

Ultimately, the precise solubility of this compound would likely require experimental determination under defined conditions, encompassing factors like temperature, solvent type, and concentration. Understanding its solubility will greatly enhance its practical applications in pharmaceutical and chemical industries, where formulation plays a critical role.

Interesting facts

Interesting Facts about 1-(Diethylaminomethyl)propyl 2,2-diphenylacetate

1-(Diethylaminomethyl)propyl 2,2-diphenylacetate is an intriguing compound that showcases the fascinating interplay between organic chemistry and medicinal applications. Here are some notable insights:

  • Structural Complexity: This compound features a unique arrangement of functional groups, including a diethylamino moiety, which plays a crucial role in its biological activity.
  • Role in Pharmacology: Compounds like this one often serve as intermediates in the synthesis of pharmaceuticals, highlighting the importance of structural modifications in drug design.
  • Usage in Research: The presence of diphenylacetate and amino groups suggests potential applications in neuropharmacology and could be of interest in exploring treatments for neurological conditions.
  • Synthetic Pathways: Understanding the synthesis of this compound can give students and researchers valuable insights into reaction mechanisms, particularly those involving nucleophilic substitutions.
  • Educational Value: Studying 1-(diethylaminomethyl)propyl 2,2-diphenylacetate provides an excellent opportunity for chemistry students to grasp concepts surrounding chirality and stereochemistry, given its complex structure.

In the larger context of organic chemistry, compounds like 1-(diethylaminomethyl)propyl 2,2-diphenylacetate are a testament to the creativity and innovation within the field. Their multifaceted nature not only fuels ongoing research but also inspires future generations of chemists to explore new horizons.

Synonyms
Ethyldiphacil
Ethyldiphenacetate
Eterofen
Iem-506
13426-07-8
1-Ethyl-2-(diethylamino)ethyl diphenylacetate
1-(diethylamino)butan-2-yl 2,2-diphenylacetate
DTXSID10928549
1-(Diethylamino)butan-2-yl diphenylacetate