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Amifostine

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Identification
Molecular formula
C5H15NO3PS2
CAS number
20537-88-6
IUPAC name
1-dimethoxyphosphorylsulfanyl-2-ethylsulfanyl-ethane;2-ethylsulfanylethoxy-dimethoxy-thioxo-lambda5-phosphane
State
State

It is a solid under standard conditions and usually provided as a powder.

Melting point (Celsius)
92.50
Melting point (Kelvin)
365.60
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
214.29g/mol
Molar mass
214.2430g/mol
Density
1.2800g/cm3
Appearence

Amifostine is a white crystalline powder. It is highly soluble in water and may appear as colorless solutions when dissolved.

Comment on solubility

Solubility of 1-Dimethoxyphosphorylsulfanyl-2-ethylsulfanyl-ethane

The solubility characteristics of 1dimethoxyphosphorylsulfanyl-2ethylsulfanylethane are quite intriguing, owing to its unique structure and functional groups. Some key points regarding its solubility include:

  • Polar Nature: The presence of dimethoxy and sulfonyl groups can enhance polar interactions, suggesting potential solubility in polar solvents like water and alcohols.
  • Hydrophobic Regions: The ethylsulfanyl groups may introduce hydrophobic characteristics that could limit solubility in purely polar solvents.
  • Solvent Compatibility: This compound may dissolve well in organic solvents such as dimethyl sulfoxide (DMSO) or acetonitrile due to their ability to interact with both polar and non-polar moieties.
  • Temperature Influence: Increased temperature might also enhance the solubility by disrupting solvent-solvent interactions, allowing for greater solute-solvent engagements.

In conclusion, while 1dimethoxyphosphorylsulfanyl-2ethylsulfanylethane showcases a complex interplay of polar and hydrophobic properties, predicting its exact solubility often requires empirical testing. However, it seems beneficial in organic solvent systems yet holds limits in aqueous environments.

Solubility of 2-Ethylsulfanylethoxy-dimethoxy-thioxo-lambda5-phosphane

The compound 2ethylsulfanylethoxy-dimethoxy-thioxo-lambda5-phosphane exhibits a rich solubility profile that is influenced by its distinct thioxo-lambda5-phosphane framework. Observations on its solubility include:

  • Functional Group Impact: The presence of sulfur and phosphorus increases polarity, likely improving solubility in polar solvents.
  • Interactions with Water: Although containing polar groups, the overall structure may resist significant solubility in water due to hydrophobic elements.
  • Best Solvent Choices: Like its counterpart, this compound might be more soluble in aprotic solvents such as acetone or ethyl acetate, which can accommodate both its polar and hydrophobic functionalities.
  • Concentration Matters: Concentration levels can significantly impact solubility, with higher concentrations potentially leading to precipitation in water.

Ultimately, the solubility of 2ethylsulfanylethoxy-dimethoxy-thioxo-lambda5-phosphane is a dynamic property influenced by solvent choice, concentration, and environmental conditions.

Interesting facts

Interesting Facts about 1-Dimethoxyphosphorylsulfanyl-2-ethylsulfanyl-ethane

This compound, characterized by a distinctive structure, is part of a fascinating class of organophosphorus compounds that exhibit unique chemical behaviors and applications. Here are some intriguing aspects of this compound:

  • Organophosphorus Chemistry: Compounds like this one are known for their significant roles in various fields, including agriculture and materials science.
  • Synthesizing Complexity: The synthesis of such compounds can involve multiple steps, highlighting the nuances and intricacies of organic synthesis techniques.
  • Reactivity: This compound may display interesting reactivity patterns due to its phosphoryl and thioether groups, potentially making it valuable for specific chemical reactions.
  • Biological Activity: Some organophosphorus compounds are under investigation for their biological properties, including potential use in pharmaceuticals or agrochemicals.
  • Environmental Impact: Understanding the stability and degradation paths of these compounds is crucial for assessing their environmental impact and safety.

As a compound that exemplifies the intersection of organophosphorus chemistry and practical application, its study could lead to breakthroughs in both industrial and environmental chemistry. The complexity and variety in the functional groups present provide a rich area for research and exploration.

Applications of the Compound

This compound may have various applications, such as:

  • In the development of new agrochemicals.
  • As an intermediate in the synthesis of more complex molecules.
  • Potential use in catalysis or as a reagent in chemical reactions.

In summary, 1-dimethoxyphosphorylsulfanyl-2-ethylsulfanyl-ethane is not only a complex compound but also a significant player in the realm of chemical research, blending theory with practical utility.

Interesting Facts about 2-Ethylsulfanylethoxy-dimethoxy-thioxo-lambda5-phosphane

This compound represents a diverse range of chemical functionalities. Here are the notable features that make it particularly interesting:

  • Thioxo Group: The presence of a thioxo group adds fascinating properties related to its reactivity and stability, influencing how this compound interacts with other chemicals.
  • Lambda5-Phosphane: This designation refers to its unique phosphorus-centered coordination, making this compound a member of a specialized subset of phosphorus compounds known for distinct chemical behaviors.
  • Diverse Applications: The unique structure may afford potential applications in various fields such as organic synthesis, medicinal chemistry, and material science.
  • Potential Biological Uses: Like many organophosphorus compounds, it may possess biological activity worth investigating for pharmaceutical applications.
  • Research Opportunities: The complexity of this compound provides a rich field for further study, particularly in its potential interactions with biological systems or its role in catalysis.

Overall, 2-ethylsulfanylethoxy-dimethoxy-thioxo-lambda5-phosphane holds intriguing potential within both academic research and industrial applications. Its distinctive structural features offer a gateway to uncovering novel chemical interactions and functionalities.


In conclusion, both compounds represent the exciting and complex world of organophosphorus chemistry, illustrating the interplay between structure and function in chemical science.

Synonyms
Methyl demeton
Demeton-methyl
Metasystox forte
Methyl Mercaptophos
Caswell No. 456
Demeton-methyl [BSI]
CCRIS 3898
UNII-B9PMD9I0FE
EPA Pesticide Chemical Code 058701
Phosphorothioic acid, O-(2-(ethylthio)ethyl) O,O-dimethyl ester, mixt. with S-(2-(ethylthio)ethyl) O,O-dimethyl phosphorothioate
Demetonmethyl
Methylmercaptophos
PHOSPHOROTHIOIC ACID, S-(2-(ETHYLTHIO)ETHYL) O,O-DIMETHYL ESTER, MIXT. CONTAINING
PHOSPHOROTHIOIC ACID, S-[2-(ETHYLTHIO)ETHYL] O,O-DIMETHYL ESTER, MIXT. CONTAINING
PHOSPHOROTHIOIC ACID, O-(2-(ETHYLTHIO)ETHYL) O,O-DIMETHYL ESTER, mixt. with S-(2-(ETHYLTHIO)ETHYL) O,O-DIMETHYLPHOSPHOROTHIOATE
PHOSPHOROTHIOIC ACID, O-[2-(ETHYLTHIO)ETHYL] O,O-DIMETHYL ESTER, mixt. with S-[2-(ETHYLTHIO)ETHYL] O,O-DIMETHYLPHOSPHOROTHIOATE
Methyl demeton (ACGIH)
METHYL DEMETON [MI]
DTXSID3040277
BAYER-21/116
BAY 15203
O,O-dimethyl S-(2-(ethylsulfinyl)ethyl)phosphorothioate
S(and O)2(Ethylthio)ethyl O,Odimethyl phosphorothioate
S (and O)-2-Ethylthioethyl O,O-dimethyl phosphorothioate
Phosphorothioic acid, S-(2-(ethylthio)et hyl) O,O-dimethyl ester
O-(2-(ETHYLTHIO)ETHYL) O,O-DIMETHYL PHOSPHOROTHIOATE MIXED WITH S-(2-(ETHYLTHIO)ETHYL) O,O-DIMETHYL PHOSPHOROTHIOATE (7:3)
Phosphorothioic acid, O(2(ethylthio)ethyl) O,Odimethyl ester, mixt. With S(2(ethylthio)ethyl) O,Odimethyl ester
867-27-6
ent 18,862
kpnpdrffwqbxgt-uhfffaoysa-n
metasystox
s-2-ethylthioethyl o,o-dimethyl phosphorothioate
un3018
8022-00-2
Demeton methyl
Methyl systox
Demeton M
Methyl-mercaptophos
Methyl demeton 25 EC
Methylmerkaptofos
Methylmerkaptofos [Czech]
Bayer 21/116
1-dimethoxyphosphorylsulfanyl-2-ethylsulfanylethane;2-ethylsulfanylethoxy-dimethoxy-sulfanylidene-lambda5-phosphane
Demton-O-Methyl
Demeton methyl powder(content>10%)
S(and O)-2-(Ethylthio)ethyl O,O-dimethyl phosphorothioate
B9PMD9I0FE
Phosphorothioic acid, O-(2-(ethylthio)ethyl) O,O-dimethyl ester, mixt. with S-(2-(ethylthio)ethyl) O,O-dimethyl ester
SCHEMBL5917224
DTXSID10925932
Q2543569
12767-20-3
O-[2-(Ethylsulfanyl)ethyl] O,O-dimethyl phosphorothioate--S-[2-(ethylsulfanyl)ethyl] O,O-dimethyl phosphorothioate (1/1)