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Clemastine hydrochloride

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Identification
Molecular formula
C21H26ClN2O2
CAS number
14976-57-9
IUPAC name
1-ethyl-2-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)pyrrolidine;hydrochloride
State
State

At room temperature, clemastine hydrochloride is a solid.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
240.00
Boiling point (Kelvin)
513.15
General information
Molecular weight
459.37g/mol
Molar mass
459.3730g/mol
Density
0.9821g/cm3
Appearence

Clemastine hydrochloride appears as a white to faintly yellowish crystalline powder. It is odorless and has a distinctly bitter taste.

Comment on solubility

Solubility of 1-ethyl-2-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)pyrrolidine;hydrochloride

The unique structure of 1-ethyl-2-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)pyrrolidine;hydrochloride presents interesting challenges regarding its solubility.

Factors Influencing Solubility

Several factors contribute to the solubility of this compound:

  • Polarity: The presence of a hydrochloride group typically increases the polarity, enhancing solubility in polar solvents like water.
  • Functional Groups: The ability of the compound to form hydrogen bonds also plays a critical role in its solubility profile.
  • Structural Complexity: The intricate tricyclic structure may hinder complete dissolution in various solvents, affecting solubility.

Expected Solubility Behavior

Based on the above factors, one can anticipate:

  • Good solubility in water due to the presence of the hydrochloride which typically increases aqueous solubility.
  • Limited solubility in non-polar solvents, as the large hydrocarbon portions of the molecule may create resistance to dissolution.
  • Increased solubility in organic solvents that can interact favorably with the tricyclic structure and aliphatic chains.

While definitive solubility data might be sparse in the literature, this analysis suggests that solubility largely depends on the interplay between the compound's unique structural features and the solvent characteristics.

Interesting facts

Interesting Facts about 1-Ethyl-2-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)pyrrolidine;hydrochloride

This compound is a fascinating example of complex organic chemistry, showcasing the intricate nature of molecular design. It belongs to the category of pyrrolidine derivatives, which are known for their versatile chemical reactivity and potential applications in medicinal chemistry. Here are some noteworthy aspects about this compound:

  • Natural Product Synthesis: The structural features of this compound suggest it may resemble compounds found in nature, potentially leading to interesting biological activities.
  • Tricyclic Structure: The presence of a tricycle within its molecular framework points to rich chemical behavior, which is often key in creating pharmaceuticals.
  • Exploration of Structure-Activity Relationships: As a parent compound and its derivatives can help researchers understand how slight changes at the molecular level affect biological activity, thus aiding drug development.
  • Research Applications: This compound may find its applications in various fields, including but not limited to, materials science, agricultural science, and medicinal chemistry.

Moreover, one of the compelling features of 1-ethyl-2-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)pyrrolidine;hydrochloride is its potential role in the development of new therapeutic agents. As researchers continuously seek novel compounds, the unique structure here stands as a testament to the creativity involved in chemical synthesis.

In summary, the complexity and unique arrangement of atoms in this compound provide a rich source for exploration and discovery in various scientific arenas.

Synonyms
piroheptine hydrochloride
Trimol
16378-22-6
Piroheptine HCl
4ZM573199N
CHEBI:32018
FK-1190
Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-ethyl-2-methyl-, hydrochloride
PYRROLIDINE, 3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-ETHYL-2-METHYL-, HYDROCHLORIDE (1:1)
Piroheptine hydrochloride [JAN]
Piroheptine (hydrochloride)
1-ethyl-2-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)pyrrolidine;hydrochloride
Piroheptine hydrochloride (JAN)
3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-1-ethyl-2-methylpyrrolidine hydrochloride
UNII-4ZM573199N
Trimol (TN)
orb1702936
SCHEMBL1318520
DTXSID00936870
GLXC-06115
MFCD01688069
PIROHEPTINE HYDROCHLORIDE [MI]
AKOS037643553
AS-16858
PIROHEPTINE HYDROCHLORIDE [WHO-DD]
HY-116550
CS-0065869
D01231
Q27881701
3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-ETHYL-2-METHYL, HYDROCHLORIDE
3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-1-ethyl-2-methylpyrrolidine--hydrogen chloride (1/1)