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1-ethyl-2-methylbenzimidazole

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Identification
Molecular formula
C10H12N2
CAS number
42990-02-7
IUPAC name
1-ethyl-2-methyl-benzimidazole
State
State

At room temperature, 1-ethyl-2-methylbenzimidazole is in a solid state, appearing as a crystalline substance.

Melting point (Celsius)
48.50
Melting point (Kelvin)
321.65
Boiling point (Celsius)
331.50
Boiling point (Kelvin)
604.65
General information
Molecular weight
160.22g/mol
Molar mass
160.2210g/mol
Density
1.0735g/cm3
Appearence

1-Ethyl-2-methylbenzimidazole is typically a yellow to brown crystalline solid. It may present as a powder depending on the specific form and purity of the sample.

Comment on solubility

Solubility of 1-ethyl-2-methyl-benzimidazole

1-ethyl-2-methyl-benzimidazole is an intriguing compound when it comes to its solubility characteristics. The solubility of this compound can be influenced by various factors including temperature, solvent characteristics, and molecular interactions. Here are some key points to consider:

  • Solvent Polarity: This compound is more likely to dissolve in organic solvents due to its non-polar aromatic structure. Common solvents include ethanol and dichloromethane.
  • Temperature Effects: Increasing the temperature generally enhances solubility in solvents. For 1-ethyl-2-methyl-benzimidazole, higher temperatures can aid in breaking solute-solute interactions.
  • Hydrogen Bonding: The presence of nitrogen in the benzimidazole structure can lead to potential hydrogen bonding, which may enhance solubility in solvents capable of hydrogen bonding.
  • Hydrophobic Interactions: The ethyl and methyl groups contribute to hydrophobic character, which can limit solubility in polar solvents such as water.

As such, it's often noted that 1-ethyl-2-methyl-benzimidazole may not be very soluble in water but finds good solubility in organic solvents. Understanding these solubility dynamics is crucial for applications in pharmaceuticals and material sciences where this compound might be utilized.

Interesting facts

Interesting Facts about 1-Ethyl-2-methyl-benzimidazole

1-Ethyl-2-methyl-benzimidazole is a fascinating compound that belongs to the class of benzimidazoles, which are notable for their diverse biological activities. This compound features a fusion of the benzene and imidazole rings, which contributes to its unique properties.

Biological Significance

One of the key aspects of 1-ethyl-2-methyl-benzimidazole is its potential as a pharmaceutical intermediary. The benzimidazole structure is prevalent in many drugs and has been studied for various applications, particularly in:

  • Antimicrobial Activity: Compounds with a benzimidazole core have shown effectiveness against a range of pathogens.
  • Anticancer Properties: Some derivatives have been investigated for their ability to inhibit tumor growth.
  • Anti-inflammatory Effects: Research suggests potential in reducing inflammation, making these compounds significant in therapeutic research.

Synthetic Applications

The synthesis of 1-ethyl-2-methyl-benzimidazole involves various methods typical in organic chemistry, often utilizing:

  • Condensation Reactions: This can lead directly to the formation of the benzimidazole ring.
  • Substitution Reactions: These reactions allow for the introduction of the ethyl and methyl groups, tailoring the compound for specific properties and applications.

Research and Development

Ongoing research into this compound includes investigations into its:

  • Mechanism of Action: Scientists are delving into how this compound interacts with biological systems.
  • Novel Derivatives: Modifying the structure can yield new compounds with enhanced efficacy or reduced side effects.

In summary, 1-ethyl-2-methyl-benzimidazole is not just a simple chemical entity; it represents a gateway to numerous therapeutic possibilities. As one researcher aptly stated, “Understanding the complexity of small molecules like 1-ethyl-2-methyl-benzimidazole could lead to significant advancements in medicinal chemistry.” The future of this compound is as bright as the research surrounding it!

Synonyms
1-Ethyl-2-methylbenzimidazole
1H-Benzimidazole, 1-ethyl-2-methyl-
EINECS 227-362-4
NKW4V930AO
NSC 93793
BRN 0127380
1-Ethyl-2-methyl-1H-benzimidazole
NSC-93793
UNII-NKW4V930AO
DTXSID9064009
IPNPFISPYWNXBR-UHFFFAOYSA-
5-23-06-00326 (Beilstein Handbook Reference)
DTXCID7042302
inchi=1/c10h12n2/c1-3-12-8(2)11-9-6-4-5-7-10(9)12/h4-7h,3h2,1-2h3
ipnpfispywnxbr-uhfffaoysa-n
5805-76-5
N-Ethyl-2-methylbenzimidazole
BENZIMIDAZOLE, 1-ETHYL-2-METHYL-
NSC93793
SCHEMBL1104819
WLN: T56 BN DNJ B2 C1
MFCD00044560
1-Ethyl-2-methyl-1H-benzimidazole #
AKOS002170028
1-ethyl-2-methyl-1H-1,3-benzodiazole
DB-072411
NS00033846