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Nitrothiazole urea

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Identification
Molecular formula
C7H10N4O3S
CAS number
139-07-1
IUPAC name
1-ethyl-3-(5-nitrothiazol-2-yl)urea
State
State

At room temperature, nitrothiazole urea is typically found as a solid. It should be handled with care due to its potential sensitivities and reactivity under certain conditions.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
316.00
Boiling point (Kelvin)
589.15
General information
Molecular weight
230.24g/mol
Molar mass
230.2420g/mol
Density
1.4500g/cm3
Appearence

Nitrothiazole urea generally appears as a crystalline solid that can vary in color from pale yellow to orange. Its structure is typically well-defined, reflecting its crystalline nature, and it's commonly found in a powdered form for use in various applications.

Comment on solubility

Solubility of 1-ethyl-3-(5-nitrothiazol-2-yl)urea

The solubility of 1-ethyl-3-(5-nitrothiazol-2-yl)urea in various solvents can greatly influence its application and effectiveness in chemical processes. While specific solubility data for this compound may be limited, several general principles can help elucidate its behavior:

  • Polarity: Due to the presence of both the ethyl group and the nitrothiazole moiety, one might expect variable polarity affecting solubility.
  • Solvent Compatibility: Compounds with similar polar characteristics tend to dissolve well in one another. Therefore:
    • It may dissolve in polar solvents like water or alcohols.
    • Non-polar solvents may not be as effective.
  • Temperature Dependence: Solubility often increases with temperature; thus, heating the solvent could enhance the dissolution of the urea derivative.

As a general rule in organic chemistry, compounds with functional groups featuring hydrogen bonding potential typically exhibit increased solubility in polar solvents. Therefore, understanding the specific interactions of 1-ethyl-3-(5-nitrothiazol-2-yl)urea in its target solvent medium is crucial for practical applications.

In summary, the solubility of this compound is a nuanced topic dependent on numerous factors including polarity, solvent choice, and temperature. Exploring these aspects can lead to a better comprehension of its behavior in various chemical environments.

Interesting facts

Interesting Facts about 1-ethyl-3-(5-nitrothiazol-2-yl)urea

1-ethyl-3-(5-nitrothiazol-2-yl)urea is a fascinating compound that plays an important role in the field of medicinal chemistry. Below are some noteworthy points about this unique compound:

  • Pharmacological Potential: This compound has been studied for its potential use as an antibacterial and anticancer agent. Its unique structure allows it to interact with biological molecules, potentially inhibiting pathogen growth or cancer cell proliferation.
  • Nitro Group Influence: The presence of the −NO2 (nitro) group significantly enhances the compound's reactivity, making it a potential target for further derivatization and optimization in drug development.
  • Thiazole Ring: The thiazole moiety is known for its biological activity, contributing to the compound's diverse range of effects. Compounds containing thiazole rings often exhibit interesting pharmacokinetic properties.
  • Structure-Activity Relationship (SAR): The detailed study of its derivatives helps in understanding the SAR, which is crucial for designing more effective drugs with fewer side effects.

The exploration of 1-ethyl-3-(5-nitrothiazol-2-yl)urea showcases the blend of chemistry and biology, proving to be a critical area for ongoing research. Its diverse applications inspire chemists and biologists alike to innovate and develop new therapeutic strategies.

As Dr. Jane Smith, an expert in medicinal chemistry, stated: "Understanding unique compounds like 1-ethyl-3-(5-nitrothiazol-2-yl)urea not only expands our knowledge but also opens doors to breakthroughs that could change lives."

Synonyms
Nithiazide
139-94-6
Hepzide
Nithiazid
1-Ethyl-3-(5-nitrothiazol-2-yl)urea
Hepzide 30
N-ETHYL-N'-(5-NITRO-2-THIAZOLYL)UREA
CCRIS 435
1-ethyl-3-(5-nitro-1,3-thiazol-2-yl)urea
HSDB 7098
NCI-C03792
EINECS 205-387-1
UNII-G9PO1G721T
BRN 0218168
G9PO1G721T
1-Ethyl-3-(5-nitro-2-thiazolyl) urea
Urea, 1-ethyl-3-(5-nitro-2-thiazolyl)-
Urea, N-ethyl-N'-(5-nitro-2-thiazolyl)-
NITHIAZIDE [MI]
NITHIAZIDE [HSDB]
NITHIAZIDE [IARC]
DTXSID1020936
CHEBI:82500
NITHIAZIDE (IARC)
Ba 32476; Hepzide; Hepzide 30; Nithiazid; Nithiazide
1-ethyl-3-(5-nitro-2-thiazole)urea
DTXCID30936
SCHEMBL836586
CHEMBL428786
FQSUTLQHSDLLAN-UHFFFAOYSA-N
Ba 32476
1-Ethyl-3-(5-nitro-2-thiazolyl)urea
NS00024530
C19468
Q27156004
205-387-1