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Brotizolam

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Identification
Molecular formula
C15H10BrClN2O
CAS number
57801-81-7
IUPAC name
1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one
State
State

This compound is typically solid at room temperature. It usually takes the form of a crystalline powder.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
318.00
Boiling point (Kelvin)
591.15
General information
Molecular weight
344.61g/mol
Molar mass
344.3200g/mol
Density
1.2385g/cm3
Appearence

Brotizolam appears as a white or almost white crystalline powder. It is typically odorless and is often stable under ordinary conditions of use and storage.

Comment on solubility

Solubility of 1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one

The solubility of 1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one is influenced by various factors, including its molecular structure and the presence of functional groups. Typically, the solubility of a compound in a given solvent can be assessed based on:

  • Polarity: Polar compounds tend to dissolve well in polar solvents, while non-polar compounds are more soluble in non-polar solvents.
  • Hydrogen Bonding: The ability of a compound to form hydrogen bonds with a solvent can significantly enhance solubility.
  • Crystal Structure: A compound's crystalline arrangement affects how easily it dissolves in a solvent.

For this particular compound, its relatively complex structure might lead to limited solubility in water due to:

  • Presence of bulky hydrophobic groups (the phenyl and ethyl portions) that can hinder interaction with water.
  • Potential for limited hydrogen bonding capabilities owing to the specific arrangement of functional groups.

As a result, it may display enhanced solubility in organic solvents such as:

  • DMSO (Dimethyl sulfoxide)
  • DMF (Dimethylformamide)

To sum up, although 1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one may show restricted solubility in polar solvents like water, its solubility profile is likely to improve in non-polar or organic solvents. Understanding solubility is fundamental to predicting the behavior of this compound in various applications.

Interesting facts

Interesting Facts about 1-Ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one

This fascinating compound belongs to a class of chemicals known for their diverse biological activities and potential therapeutic applications. Here are some engaging insights about it:

  • Structural Complexity: The compound features a complex bicyclic structure that integrates both diazepine and pyrazole motifs, known for contributing to its intriguing chemical properties.
  • Pharmacological Significance: Compounds containing the diazepin framework are often explored for their potential in treating various conditions such as anxiety, insomnia, and seizure disorders.
  • Research Interest: Its unique structure illuminates numerous research avenues—specifically, its behavior as a ligand that may interact with various neurotransmitter receptors.
  • Synthetic Pathways: The synthesis of this compound exemplifies the intricate art and science of medicinal chemistry, where chemists strive to develop efficient pathways to create complex molecular architectures.

As you explore the realm of this compound, consider “How can structural diversity enhance biological activity?” Scientists continue to unravel this enigma, making compounds like this one central to ongoing research efforts in drug discovery and development.

Overall, the study of 1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one not only deepens our understanding of chemical intricacies but also holds promise for future therapeutic innovations!

Synonyms
RIPAZEPAM
26308-28-1
Pyrazapon
Ripazepamum
CI-683
Cl-683
92000WH9C9
DTXSID1021245
1-Ethyl-4,6-dihydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5(1H)-one
Pyrazolo(4,3-e)(1,4)diazepin-5(1H)-one, 1-ethyl-4,6-dihydro-3-methyl-8-phenyl-
1-Ethyl-4,6-dihydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5(lH)-one
1-Ethyl-4,6-dihydro-3-methyl-8-phenylpyrazolo[4,3-E][1,4]diazepin-5(1H)-one
RefChem:883650
DTXCID701245
CI-683;Pyrazapon.
1-Ethyl-1,4,5,6-tetrahydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5-on
CHEBI:82529
1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one
1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5(1H)-one
Ripazepam [USAN:INN]
Ripazepamum [INN-Latin]
CCRIS 552
BRN 0819726
UNII-92000WH9C9
RIPAZEPAM [INN]
Ripazepam (USAN/INN)
RIPAZEPAM [IARC]
RIPAZEPAM [USAN]
SCHEMBL636179
CHEMBL159298
orb1699522
AKOS040749299
Pyrazolo(4,3-e)(1,4)diazepin-5(1H)-one, 4,6-dihydro-1-ethyl-3-methyl-8-phenyl-
DA-67216
HY-118657
CS-0067700
NS00126894
C19518
D05733
Q7335571
BRD-K57427145-001-01-6