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1-ethyl-3-phenylazetidine

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Identification
Molecular formula
C11H15N
CAS number
5449-46-3
IUPAC name
1-ethyl-3-phenyl-azetidine
State
State

At room temperature, 1-ethyl-3-phenylazetidine is in a liquid state. It is a relatively stable compound, although sensitive to air and light, which may cause it to discolor.

Melting point (Celsius)
-15.00
Melting point (Kelvin)
258.15
Boiling point (Celsius)
262.00
Boiling point (Kelvin)
535.15
General information
Molecular weight
161.25g/mol
Molar mass
161.2520g/mol
Density
1.0200g/cm3
Appearence

The compound 1-ethyl-3-phenylazetidine is typically a colorless to pale yellow liquid. It may have a distinct aromatic odor typical of amine-containing compounds.

Comment on solubility

Solubility of 1-ethyl-3-phenyl-azetidine

1-ethyl-3-phenyl-azetidine, a compound with a unique structure, exhibits interesting solubility characteristics due to its organic nature. Generally, solubility can be influenced by several factors including molecular structure, polarity, and the presence of functional groups. For this compound, consider the following aspects:

  • Polarity: The azetidine ring provides a moderate polarity, while the ethyl and phenyl groups influence non-polar interactions. This can affect solubility in various solvents.
  • Solvent Compatibility: It is likely to be soluble in organic solvents such as ethanol and diethyl ether, but less soluble in polar solvents like water.
  • Hydrophobic Effects: The phenyl ring enhances hydrophobic interactions, potentially decreasing solubility in polar solvents.

Overall, while 1-ethyl-3-phenyl-azetidine may not exhibit high solubility in water, it tends to dissolve well in organic solvents. This aspect makes it relevant for applications in organic chemistry and pharmaceutical formulations, where suitable solubility is critical for performance.

Interesting facts

Interesting Facts about 1-Ethyl-3-phenyl-azetidine

1-Ethyl-3-phenyl-azetidine is a fascinating compound that offers insights into the world of organic chemistry, specifically within the realm of cyclic amines. Here are some compelling aspects of this compound:

  • Cyclic Structure: As a four-membered ring structure, azetidine is considered one of the simplest cyclic amines. Its ring strain can lead to interesting reactions, making it a valuable substrate in synthetic organic chemistry.
  • Substituent Influence: The presence of an ethyl group and a phenyl group significantly influences the properties and reactivity of the azetidine ring, affecting its stability and interaction with other molecules.
  • Biological Relevance: Compounds sharing structural similarities with 1-ethyl-3-phenyl-azetidine have been investigated for their potential activity as pharmaceuticals, particularly in the field of neurochemistry and as potential analgesics.
  • Reactivity: Due to its unique structure, it can undergo various reactions, such as nucleophilic substitutions and cycloadditions, making it a versatile intermediate in organic synthesis.
  • Research Applications: This compound, along with its derivatives, is commonly studied in the context of drug design, where modifications can lead to enhanced bioactivity or selectivity for specific biological targets.

In the words of chemists: "Understanding compounds like 1-ethyl-3-phenyl-azetidine not only deepens our appreciation for molecular complexity but also enriches the toolkit available for medicinal chemistry."

This compound represents the intersection of organic structure and function, reinforcing the importance of molecular design in advancing scientific knowledge.

Synonyms
1-Ethyl-3-phenylazetidine
AZETIDINE, 1-ETHYL-3-PHENYL-
3-Fenil-1-etilazetina
3-Fenil-1-etilazetina [Italian]
L 2049
BRN 1424831
4363-16-0
DTXSID30195897
DTXCID70118388
5-20-06-00284 (beilstein handbook reference)
SCHEMBL19567291