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Diphenoxylate hydrochloride

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Identification
Molecular formula
C30H32ClNO3
CAS number
3810-80-8
IUPAC name
(1-ethyl-3-piperidyl) 2-cyclopentyl-2-hydroxy-2-phenyl-acetate;hydrochloride
State
State

Typically, diphenoxylate hydrochloride at room temperature is a solid. It is presented in the form of tablets or as an ingredient in oral liquid medications, commonly used as an antidiarrheal agent.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
0.00g/mol
Molar mass
528.0710g/mol
Density
1.1800g/cm3
Appearence

Diphenoxylate hydrochloride appears as a white or almost white crystalline powder. It is odorless or may have a slight characteristic odor. The compound is sensitive to light and should be stored in well-closed containers away from direct light sources.

Comment on solubility

Solubility of (1-ethyl-3-piperidyl) 2-cyclopentyl-2-hydroxy-2-phenyl-acetate; hydrochloride

The solubility characteristics of (1-ethyl-3-piperidyl) 2-cyclopentyl-2-hydroxy-2-phenyl-acetate; hydrochloride are influenced by its molecular structure and the presence of functional groups. Generally, the hydrochloride form of such compounds tends to exhibit enhanced solubility in polar solvents, particularly in water due to the ionic nature of the hydrochloride salt. Key aspects affecting its solubility include:

  • Polarity: The presence of polar functional groups typically increases solvent interaction.
  • Hydrogen Bonding: The ability to form hydrogen bonds contributes to the solubility in polar solvents.
  • Temperature: Increased temperature often results in increased solubility for solid compounds.

It is also worth noting that solubility can be significantly different when considering:

  • Different temperatures and pH levels of the solution.
  • The presence of other solutes that may either facilitate or hinder solubility.

As the compound is utilized in various applications, understanding its solubility is crucial for effective formulation and bioavailability. In summary, the solubility of this compound is expected to be generally good in aqueous solutions, enhancing its potential use in pharmaceutical contexts. However, specific experimental data is essential for precise solubility determinations in practical applications.

Interesting facts

Interesting Facts about (1-ethyl-3-piperidyl) 2-cyclopentyl-2-hydroxy-2-phenyl-acetate; hydrochloride

The compound (1-ethyl-3-piperidyl) 2-cyclopentyl-2-hydroxy-2-phenyl-acetate; hydrochloride is intriguing not just for its complex structure but also for its potential applications. Here are some notable aspects:

  • Pharmacological Potential: This compound may have applications in medicinal chemistry, particularly in the development of drugs targeting neurological disorders. The piperidine moiety is often associated with various neurological functions.
  • Chemical Variability: The presence of cyclopentyl and phenyl groups enhances the compound's ability to interact with biological targets. These groups can influence the compound's lipophilicity, affecting its absorption and distribution in biological systems.
  • Synthesis Insight: The multi-step synthesis of this compound provides a rich area for exploration in organic chemistry methods, including the importance of functional group transformations and stereochemical considerations.
  • Understanding Hydrochloride Forms: The hydrochloride form is crucial in enhancing stability and solubility, making it easier for pharmaceutical formulations. It often affects how the compound behaves in biological systems.
  • Research Applications: Due to its structural features, this compound may also serve as a probe in research, aiding scientists in understanding interactions at a molecular level.

This compound exemplifies the intricate relationship between chemical structure and biological activity, painting a larger picture of how slight variations in molecular design can lead to significant differences in function. As such, it serves as a reminder of the exciting possibilities within the realm of chemical research.

Synonyms
N-Ethyl-3-piperidyl phenylcyclopentylglycolate hydrochloride
A3XNR0EK4Q
1910-67-4
NSC-232091
1-Ethyl-3-piperidyl-alpha-phenylcyclopentylglycolate hydrochloride
UNII-A3XNR0EK4Q
DTXSID50940700
NSC232091
Mandelic acid, .alpha.-cyclopentyl-, 1-ethyl-3-piperidyl ester hydrochloride
NSC 232091
Mandelic acid, 1-ethyl-3-piperidyl ester hydrochloride
N-ethyl-3-piperidyl phenylcyclopentyl-glycolate hydrochloride
Mandelic acid, alpha-cyclopentyl-, 1-ethyl-3-piperidyl ester hydrochloride
1-Ethylpiperidin-3-yl cyclopentyl(hydroxy)phenylacetate--hydrogen chloride (1/1)
BENZENEACETIC ACID, .ALPHA.-CYCLOPENTYL-.ALPHA.-HYDROXY-, 1-ETHYL-3-PIPERIDINYL ESTER, HYDROCHLORIDE (1:1)
Benzeneacetic acid, alpha-cyclopentyl-alpha-hydroxy-, 1-ethyl-3-piperidinyl ester, hydrochloride (1:1)