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Loperamide Hydrochloride

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Identification
Molecular formula
C29H33ClNO2
CAS number
34552-83-5
IUPAC name
(1-ethylpiperidin-1-ium-2-yl)methyl 2-ethoxy-2,2-diphenyl-acetate;chloride
State
State

At room temperature, Loperamide Hydrochloride remains in a solid state. It is typically used in its solid form for pharmaceutical formulations, such as tablets and capsules. The compound is stable under standard temperature and pressure conditions but should be stored away from moisture to maintain its efficiency and integrity.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.00
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.00
General information
Molecular weight
513.51g/mol
Molar mass
513.5060g/mol
Density
1.2584g/cm3
Appearence

This compound appears as a white or almost white crystalline or amorphous powder, depending on its form. It is sparingly soluble in water and freely soluble in methanol. When presented as a fine powder, it has a tendency to become airborne and is best handled with care to prevent inhalation.

Comment on solubility

Solubility Characteristics of (1-ethylpiperidin-1-ium-2-yl)methyl 2-ethoxy-2,2-diphenyl-acetate;chloride

The solubility of the compound (1-ethylpiperidin-1-ium-2-yl)methyl 2-ethoxy-2,2-diphenyl-acetate;chloride can be influenced by multiple factors, particularly its molecular structure which features both hydrophobic and hydrophilic components.

Factors Influencing Solubility

  • Polar Functional Groups: The presence of ethoxy and acetate groups enhances the hydrophilicity of the molecule.
  • Alkyl Chains: The ethyl piperidinium moiety adds a degree of hydrophobicity, which may reduce overall solubility in water but can facilitate solubility in organic solvents.
  • Salt Form: Being a chloride salt, the compound may exhibit increased solubility in polar solvents like water, enhancing its bioavailability in certain applications.

As a general observation, ionic compounds tend to be more soluble in polar solvents, while those with significant hydrophobic characteristics are better suited for non-polar environments. Therefore, one might anticipate that:

  1. This compound is likely soluble in polar solvents such as water due to its ionic nature.
  2. It may also find good solubility in organic solvents like ethanol or methanol due to the presence of the ethoxy group.
  3. Under certain conditions, such as temperature variations and the presence of other solubilizing agents, the solubility can be optimized.

In summary, the solubility of (1-ethylpiperidin-1-ium-2-yl)methyl 2-ethoxy-2,2-diphenyl-acetate;chloride is complex and context-dependent, with potential for significant variation based on the solvent used and the physical conditions applied. Understanding these solubility behaviors is crucial in utilizing this compound effectively in various chemical applications.

Interesting facts

Interesting Facts about (1-ethylpiperidin-1-ium-2-yl)methyl 2-ethoxy-2,2-diphenyl-acetate;chloride

This unique compound, known as (1-ethylpiperidin-1-ium-2-yl)methyl 2-ethoxy-2,2-diphenyl-acetate;chloride, belongs to a fascinating class of organic chemicals that exhibit a variety of interesting properties and applications.

Key Highlights:

  • Ionic Nature: The presence of the piperidinium structure makes this compound ionic, which can enhance its solubility and reactivity in various solvents.
  • Pharmacological Potential: Due to its piperidine ring, this compound could possess pharmacological activities, possibly influencing nervous system functions or acting as a ligand in drug discovery.
  • Versatility in Synthesis: The synthesis of compounds featuring the diphenyl acetate moiety often involves innovative organic reactions, showcasing the creativity involved in chemical synthesis.
  • Electroactive Properties: Ionic compounds may exhibit interesting electroactive characteristics, making them suitable for applications in sensors and actuators.
  • Complex Interactions: The unique structure of the ethoxy and diphenyl groups can lead to complex interactions with biological systems, emphasizing its importance in medicinal chemistry.

In summary, the compound (1-ethylpiperidin-1-ium-2-yl)methyl 2-ethoxy-2,2-diphenyl-acetate;chloride illustrates the importance of interdisciplinary approaches in chemistry. As researchers continue to explore its properties and potential applications, this compound could become an interesting focus in pharmacology and materials science.

Synonyms
2909-94-6
Acetic acid, 2,2-diphenyl-2-ethoxy-, (1-ethyl-2-piperidyl)methyl ester, hydrochloride
2,2-Diphenyl-2-ethoxyacetic acid (1-ethyl-2-piperidyl)methyl ester hydrochloride